Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy

Origin and Differentiation of Nerve-Associated Macrophages

(2020) Julia Kolter et al.   JOURNAL OF IMMUNOLOGY

Time Course of Inflammation in Dorsal Root Ganglia Correlates with Differential Reversibility of Mechanical Allodynia

(2020) Myung-chul Noh et al.   NEUROSCIENCE

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

(2020) Inmaculada Bravo‐Caparrós et al.   FASEB JOURNAL

Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice

(2020) Raquel Tonello et al.   ANESTHESIOLOGY

The CCL2 elevation in primary afferent fibers produces zymosan-induced hyperalgesia through microglia-mediated neuronal activation in the spinal dorsal horn

(2019) Sungkun Chun et al.   BRAIN RESEARCH BULLETIN

Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons

(2019) Ouyang Chen et al.   CURRENT OPINION IN NEUROBIOLOGY

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

(2018) Karli Montague et al.   Journal of Neuroinflammation

Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice

(2018) Andrew J. Shepherd et al.   NEUROPHARMACOLOGY

Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity

(2018) Amina M. Illias et al.   PAIN

Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease

(2018) Vinko Palada et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification of potential mechanism and hub genes for neuropathic pain by expression-based genome-wide association study

(2018) Yu Gu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An Intimate Role for Adult Dorsal Root Ganglia Resident Cycling Cells in the Generation of Local Macrophages and Satellite Glial Cells

(2018) Anand Krishnan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain

(2018) Shaimaa I. A. Ibrahim et al.   Frontiers in Cellular Neuroscience

Increased local expressions of CX3CL1 and CCL2 are related to clinical severity in lumbar disk herniation patients with sciatic pain

(2017) Zhen-Yu Peng et al.   Journal of Pain Research

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain

(2016) Wenrui Xie et al.   JOURNAL OF NEUROSCIENCE

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve

(2015) Juliette Van Steenwinckel et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

(2014) Elizabeth A. Old et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of Chemokine CCL2/CCR2 Signaling in the Dorsal Root Ganglion and Spinal Cord to the Maintenance of Neuropathic Pain in a Rat Model of Lumbar Disc Herniation

(2014) Xiang Zhu et al.   JOURNAL OF PAIN

Monocytes/Macrophages Control Resolution of Transient Inflammatory Pain

(2014) Hanneke L.D.M. Willemen et al.   JOURNAL OF PAIN

Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2013) Haijun Zhang et al.   JOURNAL OF PAIN

The Connection of Monocytes and Reactive Oxygen Species in Pain

(2013) Dagmar Hackel et al.   PLoS One

Heterogeneity of macrophages in injured trigeminal nerves: Cytokine/chemokine expressing vs. phagocytic macrophages

(2012) SeungHwan Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Estimating Efficacy and Drug ED50's Using von Frey Thresholds: Impact of Weber's Law and Log Transformation

(2012) Charles Mills et al.   JOURNAL OF PAIN

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion

(2012) W. Xie et al.   NEUROSCIENCE

CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury

(2011) J. Van Steenwinckel et al.   JOURNAL OF NEUROSCIENCE

Blocking Spinal CCR2 with AZ889 Reversed Hyperalgesia in a Model of Neuropathic Pain

(2011) Alexandre Serrano et al.   Molecular Pain

Site-specific subtypes of macrophages recruited after peripheral nerve injury

(2011) Tadasuke Komori et al.   NEUROREPORT

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Serum Monocyte Chemotactic Protein-1 Concentrations Distinguish Patients With Ankylosing Spondylitis From Patients With Mechanical Low Back Pain

(2010) Consuelo Romero-Sanchez et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Chemokines and pain mechanisms

(2008) Catherine Abbadie et al.   BRAIN RESEARCH REVIEWS

Species and strain differences in rodent sciatic nerve anatomy: Implications for studies of neuropathic pain

(2008) Marcel Rigaud et al.   PAIN