Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-  in Lupus Patients In Vivo

(2014) S. N. Kariuki et al.   JOURNAL OF IMMUNOLOGY

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study

(2012) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

(2012) Mark A Jensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Interferon-beta Responses in Multiple Sclerosis Immune Cells Associated With High-Dose Statins

(2012) Xuan Feng et al.   ARCHIVES OF NEUROLOGY

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

(2012) Tharian S. Cherian et al.   ARTHRITIS AND RHEUMATISM

Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus

(2012) Yelena Koldobskaya et al.   Clinical & Developmental Immunology

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-  and Serologic Autoimmunity in Lupus Patients

(2011) T. Robinson et al.   JOURNAL OF IMMUNOLOGY

Interferon Alpha as a Primary Pathogenic Factor in Human Lupus

(2011) Timothy B. Niewold   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Autoimmune Disease Risk Allele of UBE2L3 in African American Patients with Systemic Lupus Erythematosus: A Recessive Effect Upon Subphenotypes

(2011) S. AGIK et al.   JOURNAL OF RHEUMATOLOGY

Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis

(2011) Xuan Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon regulatory factors in human lupus pathogenesis

(2011) Rafah Salloum et al.   Translational Research

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

(2011) Olga Gorlova et al.   PLoS Genetics

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

(2010) Corinna E. Weckerle et al.   ARTHRITIS AND RHEUMATISM

The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

(2010) Corinna E. Weckerle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Promoter Variant ofPIK3C3Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

(2010) Silvia N. Kariuki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Interferon Alpha in Systemic Lupus Erythematosus

(2010) Timothy B. Niewold et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Gene-Gene-Sex Interaction in Cytokine Gene Polymorphisms Revealed by Serum Interferon Alpha Phenotype in Juvenile Dermatomyositis

(2010) Timothy B. Niewold et al.   JOURNAL OF PEDIATRICS

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

(2010) Silvia N Kariuki et al.   ARTHRITIS RESEARCH & THERAPY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Genetic regulation of serum cytokines in systemic lupus erythematosus

(2009) Silvia N. Kariuki et al.   Translational Research

Age‐ and sex‐related patterns of serum interferon‐α activity in lupus families

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro–positive mothers of children with neonatal lupus

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Interferon Alpha-Induced Lupus

(2008) Timothy B. Niewold   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS