shRNA-induced saturation of the microRNA pathway in the rat brain

Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response

(2012) Anne A. Kan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat

(2012) D.L. Choi et al.   NEUROSCIENCE

An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons

(2011) Christina E. Khodr et al.   BRAIN RESEARCH

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner

(2011) Marijke W.A. de Backer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design

(2011) J N Martin et al.   GENE THERAPY

Constitutive Expression of Short Hairpin RNA in Vivo Triggers Buildup of Mature Hairpin Molecules

(2011) M. Ahn et al.   HUMAN GENE THERAPY

Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

(2011) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

(2010) Erich M Ehlert et al.   BMC NEUROSCIENCE

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

(2010) Dirk Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance

(2010) M W A de Backer et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

(2010) Yi-Chun Loraine Tung et al.   PLoS One

Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons

(2009) Ayse Ulusoy et al.   MOLECULAR THERAPY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites

(2008) S. Diederichs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA