Article
Endocrinology & Metabolism
Nadejda Bozadjieva-Kramer, Rachel A. Ross, David Q. Johnson, Henning Fenselau, David L. Haggerty, Brady Atwood, Bradford Lowell, Jonathan N. Flak
Summary: The study reveals that PACAP plays crucial roles in regulating metabolic rate and energy balance through multiple effector systems on various time scales, highlighting the diverse functions of PACAP in overall energy homeostasis.
Article
Integrative & Complementary Medicine
Chuang Zhao, Xiao-yan Li, Zun-yuan Li, Miao Li, Zhi-dan Liu
Summary: The study found that moxibustion therapy can regulate the Treg/Th17 cell balance in the RA mouse model by modulating the miR-221/SOCS3 axis.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Biochemistry & Molecular Biology
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Sebastian Zagmutt, Nuria Casals, Daniela Cota, Rosalia Rodriguez-Rodriguez
Summary: The hypothalamus plays a crucial role in the pathogenesis of obesity, with disrupted endocannabinoid system considered a landmark indicator. Recent research has expanded knowledge of the complex endocannabinoid system, focusing on CB receptors, ligands, non-CB receptors, and metabolizing enzymes, particularly in the hypothalamus. The insights gained have provided promising targets for tackling obesity and related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Ryota Masuzaki, Tatsuo Kanda, Reina Sasaki, Naoki Matsumoto, Kazushige Nirei, Masahiro Ogawa, Seth J. Karp, Mitsuhiko Moriyama, Hirofumi Kogure
Summary: Hepatocellular carcinoma (HCC) is a common malignancy worldwide and the SOCS family proteins play an important role in HCC development and liver regeneration. By negatively regulating cytokine signaling, SOCS proteins can modulate cellular growth, differentiation, and immune response. In HCC treatment, SOCS proteins may be potential targets for controlling cell proliferation and immune response.
Review
Biochemistry & Molecular Biology
Eva Prida, Sara Alvarez-Delgado, Raquel Perez-Lois, Mateo Soto-Tielas, Ana Estany-Gestal, Johan Ferno, Luisa Maria Seoane, Mar Quinones, Omar Al-Massadi
Summary: Fibroblast growth factor 21 plays a key role in regulating metabolism and has direct effects on the central nervous system. It is involved in maintaining energy homeostasis, glucose and lipid metabolism, and insulin sensitivity. Recombinant fibroblast growth factor 21 therapies have shown efficacy in counteracting obesity and related metabolic disorders in rodents and nonhuman primates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Maryam Dokhanchi, Katayoon Pakravan, Sara Zareian, Bashdar Mahmud Hussen, Mahsa Farid, Ehsan Razmara, Majid Mossahebi-Mohammadi, William C. Cho, Sadegh Babashah
Summary: In this study, a signature of four circulating serum-derived miRNAs (miR-19a-3p, miR-203-3p, miR-221-3p, and let-7f-5p) was identified as a novel diagnostic biomarker for CRC, with their expressions positively correlated with lymph node metastasis. MiR-221-3p transferred by CRC-EVs promoted endothelial cell angiogenesis by targeting SOCS3 and regulating the STAT3/VEGFR-2 signaling pathway. The findings highlight the potential clinical significance of miR-221-3p in CRC and its role in promoting tumor angiogenesis.
Review
Cell Biology
Jose Donato, Frederick Wasinski, Isadora C. Furigo, Martin Metzger, Renata Frazao
Summary: Growth hormone plays a crucial role in regulating metabolism in the brain, affecting food intake, energy expenditure, blood sugar levels, and neuroendocrine changes. It acts as a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis.
Article
Biotechnology & Applied Microbiology
Xiaojie Yang, Mengyue Tian, Yukang Lin, Liming Li, Xinhai Sun, Zhenyang Zhang, Mingqiang Kang, Jiangbo Lin
Summary: This study aimed to analyze the diagnostic, therapeutic, and prognostic value of SOCS3 in pancancer and investigate its role in ESCA. Bioinformatics methods were used to explore SOCS3 expression in various cancers and evaluate its potential role. The results showed upregulation of SOCS3 in 10 cancers, downregulation in 12 cancers, and upregulation in ESCA. Mutations and amplification were the main causes of abnormal SOCS3 expression. In ESCA, SOCS3 expression was negatively correlated with methylation and associated with overall survival. SOCS3 was also related to immune response, tumor purity, immune checkpoint genes, and drug sensitivity.
HUMAN GENE THERAPY
(2023)
Article
Food Science & Technology
Fatima G. Velazquez-Gonzalez, Mercedes Urquiza-Martinez, Raul Manhaes-de-Castro, Pedro A. Romero-Juarez, Zaira I. Bedolla-Valdez, Juan M. Ponce-Perez, Estefania Farias-Gaytan, Maria S. Vazquez-Garciduenas, Gerardo Vazquez-Marrufo, Ana E. Toscano, Luz Torner, Jose Perez-Villarreal, Omar Guzman-Quevedo
Summary: This study aimed to evaluate the functional effects of avocado seed on diet-induced obese mice. The results showed that supplementation with avocado seed led to reduced body weight, delayed satiety, increased physical activity, and induced specific gene expressions in hypothalamus and white adipose tissue. This suggests that avocado seed could be a potential raw material for the development of functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Endocrinology & Metabolism
Joao Paulo Cavalcanti-de-Albuquerque, Jose Donato Jr
Summary: Energy balance is finely regulated through the balance of energy expenditure and energy intake. Negative energy balance leads to weight loss, while positive energy balance promotes weight gain. The impact of physical exercise on energy balance, particularly through the melanocortin system and other hypothalamic neural circuitries, is still not fully understood. Further research in this area may provide insights into obesity etiology and new approaches to weight loss treatments.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Berengere Coupe, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Penicaud, Tamas L. Horvath, Sebastien G. Bouret
Summary: The study investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the ventromedial nucleus of the hypothalamus (VMH) under normal and fasting conditions. It was found that autophagy is nutritionally regulated in VMH neurons and participates in controlling energy homeostasis during fasting.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Antoine Rohrbach, Emilie Caron, Rafik Dali, Maxime Brunner, Roxane Pasquettaz, Irina Kolotuev, Federico Santoni, Bernard Thorens, Fanny Langlet
Summary: This study investigated the role of GCK-expressing tanycytes in the regulation of energy balance in mice. The results showed that Gck deletion induced the death of tanycytes and affected adiposity in mice, as well as NPY neuron function.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Mar Quinones, Rene Hernandez-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y. H. Lam, Ana Senra, Johan Ferno, Alicia Garcia Gomez-Valades, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel Lopez, Carlos Dieguez, Omar Al-Massadi, Ruben Nogueiras
Summary: SIRT3 in the hypothalamus, specifically in POMC neurons, plays a key role in regulating energy balance, leading to improved metabolic parameters and negative energy balance in male mice.
Article
Biochemistry & Molecular Biology
Nan Zhang, Jiaping Wei, Heng Jiang, Huichen Ge, Yang Zheng, Xiangkun Meng, Kun Qian, Jianjun Wang
Summary: This study found that arginine kinase (AK) plays an important role in insect response to insecticides by regulating cellular energy balance and participating in detoxification.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Frederick Wasinski, Franco Barrile, Joao A. B. Pedroso, Paula G. F. Quaresma, Willian O. dos Santos, Edward O. List, John J. Kopchick, Mario Perello, Jose Donato
Summary: The study demonstrates the essential role of GHR signaling in the brain for the orexigenic effect of ghrelin, independent of GH action on ARH (AgRP/NPY) neurons.