Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid Proteins

(2011) Amit C Nathwani et al.   MOLECULAR THERAPY

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

(2011) Federico Mingozzi et al.   NATURE REVIEWS GENETICS

MicroRNAs Add a New Dimension to Cardiovascular Disease

(2010) Eric M. Small et al.   CIRCULATION

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

(2009) Lennart Suckau et al.   CIRCULATION

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

The miR-430/427/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection

(2009) Alessandro Rosa et al.   DEVELOPMENTAL CELL

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

(2009) Brian E. Jaski et al.   JOURNAL OF CARDIAC FAILURE

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Promotion of embryonic cortico-cerebral neuronogenesis by miR-124

(2009) Nicola Maiorano et al.   Neural Development

Reversing Advanced Heart Failure by Targeting Ca2+ Cycling

(2008) David M. Kaye et al.   Annual Review of Medicine

MicroRNAs: novel regulators in cardiac development and disease

(2008) T. Thum et al.   CARDIOVASCULAR RESEARCH

Gene Therapy in Heart Failure

(2008) Leif Erik Vinge et al.   CIRCULATION RESEARCH

Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice

(2008) Chang Yin et al.   FEBS LETTERS

Design of a Phase 1/2 Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Heart Failure

(2008) Roger J. Hajjar et al.   JOURNAL OF CARDIAC FAILURE

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

(2008) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines

(2008) Lawrence T Bish et al.   MOLECULAR THERAPY

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Expression profiling reveals heightened apoptosis and supports fiber size economy in the murine muscles of mastication

(2008) Marianna Evans et al.   PHYSIOLOGICAL GENOMICS

rAAV-asPLB transfer attenuates abnormal sarcoplasmic reticulum Ca2+-ATPase activity and cardiac dysfunction in rats with myocardial infarction

(2007) Xiao-Yan Zhao et al.   EUROPEAN JOURNAL OF HEART FAILURE

AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes

(2007) Lourdes M. Andino et al.   JOURNAL OF GENE MEDICINE