Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals

TRAF6 Stimulates the Tumor-Promoting Effects of TGF  Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

(2014) S. K. Gudey et al.   Science Signaling

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

(2013) Yhun Yhong Sheen et al.   Biomolecules & Therapeutics

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI

(2013) Junwen Zhang et al.   CELLULAR SIGNALLING

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo

(2013) Mona El Khatib et al.   PLoS One

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Receptor Tyrosine Kinases in the Nucleus

(2013) G. Carpenter et al.   Cold Spring Harbor Perspectives in Biology

Signaling from the secretory granule to the nucleus

(2012) Chitra Rajagopal et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

Post-translational regulation of TGF-β receptor and Smad signaling

(2012) Pinglong Xu et al.   FEBS LETTERS

Protein Inhibitor of Activated STAT3 (PIAS3) Protein Promotes SUMOylation and Nuclear Sequestration of the Intracellular Domain of ErbB4 Protein

(2012) Maria Sundvall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Translocation of Type I Transforming Growth Factor   Receptor Confers a Novel Function in RNA Processing

(2012) M. Chandra et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteolytic Processing of ErbB4 in Breast Cancer

(2012) Maija Hollmén et al.   PLoS One

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli

(2011) Anahita Hamidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

(2011) Daniel T. Starczynowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Intramembrane Proteolysis in Regulated Protein Trafficking

(2011) Marius K. Lemberg   TRAFFIC

Molecular and Cellular Mechanisms of Ectodomain Shedding

(2010) Kazutaka Hayashida et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Dictyostelium possesses highly diverged presenilin/ -secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/ -secretase complex

(2010) V. C. McMains et al.   Disease Models & Mechanisms

The TAK1–TRAF6 signalling pathway

(2010) Marene Landström   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

(2009) J. V. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear Translocation of the Epidermal Growth Factor Receptor Family Membrane Tyrosine Kinase Receptors

(2009) S.-C. Wang et al.   CLINICAL CANCER RESEARCH

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms

(2009) M Hollmén et al.   ONCOGENE

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

The role of protease activity in ErbB biology

(2008) Carl P. Blobel et al.   EXPERIMENTAL CELL RESEARCH

Trafficking of receptor tyrosine kinases to the nucleus

(2008) Graham Carpenter et al.   EXPERIMENTAL CELL RESEARCH

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY