Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy

AKT1 (E17K) Mutation in Pancreatic Cancer

(2014) Azim Mohamedali et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Tyrosine Kinase Blockers: New Hope for Successful Cancer Therapy

(2012) Dariusz Pytel et al.   Anti-Cancer Agents in Medicinal Chemistry

Heterozygous deficiency of δ-catenin impairs pathological angiogenesis

(2010) Laura M. DeBusk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of protective and therapeutic anti-pancreatic cancer immunity using a reconstructed MUC1 DNA vaccine

(2009) Yefei Rong et al.   BMC CANCER

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk

(2009) Meng Chen et al.   CARCINOGENESIS

PIK3CA Mutation Associates with Improved Outcome in Breast Cancer

(2009) K. Kalinsky et al.   CLINICAL CANCER RESEARCH

Phosphoinositide 3-Kinase Mutations in Breast Cancer: A "Good" Activating Mutation?

(2009) S. Di Cosimo et al.   CLINICAL CANCER RESEARCH

Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer

(2009) P. Gulhati et al.   CLINICAL CANCER RESEARCH

Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

(2009) D. Sarker et al.   CLINICAL CANCER RESEARCH

Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway

(2009) Todd Morgan et al.   CURRENT CANCER DRUG TARGETS

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

(2009) Yoram Cohen et al.   GYNECOLOGIC ONCOLOGY

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

The notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

(2009) Ying Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles

(2009) Yan Zeng et al.   Molecular Cancer

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

(2009) J. R. Pritchard et al.   MOLECULAR CANCER THERAPEUTICS

Cancer linked to Alzheimer disease but not vascular dementia

(2009) C. M. Roe et al.   NEUROLOGY

AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K

(2009) J M Askham et al.   ONCOGENE

Recent Developments in Anti-Cancer Agents Targeting the Ras/Raf/ MEK/ERK Pathway

(2009) Kwong-Kwok Wong   Recent Patents on Anti-Cancer Drug Discovery

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of E2F1 as a positive transcriptional regulator for δ-catenin

(2008) Kwonseop Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRF-4 functions as a tumor suppressor in early B-cell development

(2008) J. Acquaviva et al.   BLOOD

Psychological intervention and health outcomes among women treated for breast cancer: A review of stress pathways and biological mediators

(2008) Bonnie A. McGregor et al.   BRAIN BEHAVIOR AND IMMUNITY

The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene

(2008) Jah-Yao Liu et al.   CANCER LETTERS

Knockdown of the Transforming Growth Factor-  Type III Receptor Impairs Motility and Invasion of Metastatic Cancer Cells

(2008) T. L. Criswell et al.   CANCER RESEARCH

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110  Predisposes Mammary Glands to Neoplastic Transformation

(2008) O. Renner et al.   CANCER RESEARCH

Loss of Integrin  1 1 Ameliorates Kras-Induced Lung Cancer

(2008) I. Macias-Perez et al.   CANCER RESEARCH

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

(2008) P. Zhang et al.   CLINICAL CANCER RESEARCH

Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

(2008) B. B. Friday et al.   CLINICAL CANCER RESEARCH

Notch Signaling: A Potential Therapeutic Target in Prostate Cancer

(2008) M. Villaronga et al.   CURRENT CANCER DRUG TARGETS

The Notch pathway in prostate development and cancer

(2008) Kevin G. Leong et al.   DIFFERENTIATION

Lack of Nuclear Expression of Hairy and Enhancer of Split-1 (HES1) in Pancreatic Endocrine Tumors

(2008) T. Johansson et al.   HORMONE AND METABOLIC RESEARCH

An activating mutation inAKT1in human prostate cancer

(2008) Joost L. Boormans et al.   INTERNATIONAL JOURNAL OF CANCER

Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

(2008) Lin-Yu Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

microRNAs and prostate cancer

(2008) Xu-Bao Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells

(2008) Alla Musiyenko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Preventive Services Task Force Recommends Against PSA Screening After Age 75

(2008) Renee Twombly   JNCI-Journal of the National Cancer Institute

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE

Rb/E2F4 and Smad2/3 link survivin to TGF-β-induced apoptosis and tumor progression

(2008) J Yang et al.   ONCOGENE

Increased nucleotide polymorphic changes in the 5′-untranslated region of δ-catenin (CTNND2) gene in prostate cancer

(2008) T Wang et al.   ONCOGENE

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation

(2008) P Taghavi et al.   ONCOGENE

AKT1 E17K in human solid tumours

(2008) F E Bleeker et al.   ONCOGENE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

Expression of microRNAs and protein‐coding genes associated with perineural invasion in prostate cancer

(2008) Robyn L. Prueitt et al.   PROSTATE

Activation of β-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration

(2008) Xiuping Yu et al.   PROSTATE

Loss of mir-146a function in hormone-refractory prostate cancer

(2008) S.-L. Lin et al.   RNA

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH