Article
Infectious Diseases
Noriko Kitamura, Tansy Edwards, Lina Madaniyazi, Duc-Anh Dang, Michiko Toizumi, Paul Fine, Lay-Myint Yoshida, Lien Thuy Le, Thao Thi Thu Le, Minh Xuan Bui, Hung Thai Do, Hien-Anh Thi Nguyen
Summary: This study aimed to measure the seroprevalence of anti-diphtheria toxoid antibodies in well-vaccinated communities in Vietnam and estimate the duration of protective immunity after vaccination. The results showed low seroprevalence and a decline in antibody levels over time. A school-entry booster dose is recommended in Vietnam.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Jiayi Pan, Wuyi Zeng, Jiangtao Jia, Yi Shi, Danni Wang, Jun Dong, Zixuan Fang, Jiashan He, Xinyu Yang, Rong Zhang, Menghua He, Maoping Huang, Bishi Fu, Bei Zhong, Hui Liu
Summary: Dendritic cells (DCs), as professional antigen-presenting cells, play a crucial role in cancer treatment. DC vaccines have been widely studied for their therapeutic effects on cancer. However, the overall clinical efficacy of DC vaccines is not satisfactory, and there is a need to enhance their efficacy. In this study, a novel therapeutic MUC1-Vax tumor vaccine was developed based on the immune checkpoint PD-L1 and tumor-associated antigen MUC1. The vaccine demonstrated a strong anti-tumor effect in immunized mice.
Article
Immunology
Jingjing Wang, Yu Liu, Weihua Ni, Xinjie Wu, Jianhong Zhou, Zenan Zhang, Hongyue Zhou, Nannan Zhang, Mengyu Jiang, Qianyu Sang, Hongyan Yuan, Guixiang Tai
Summary: This study found that TRAF6 overexpression promotes the maturation of dendritic cells (DCs) and activates Th1 responses. In a therapeutic tumor model, TRAF6-overexpressing DCs significantly inhibited tumor growth and enhanced specific immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chuan Wang, Yingqi Jin, Jiewen Wang, Kang Zheng, Aihua Lei, Chunxue Lu, Shuzhi Wang, Yimou Wu
Summary: The study evaluated the protective immunity of pcDNA3.1(+)/CPSIT_p7 against C. psittaci infection in BALB/c mice. The results showed that pcDNA3.1(+)/CPSIT_p7 can induce strong humoral and cellular immune responses, reduce pulmonary pathological lesions, C. psittaci load in the lungs, and suppress its dissemination in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
K. C. Natasha, L. W. Preston Church, Pouria Riyahi, Sumana Chakravarty, Robert A. Seder, Judith E. Epstein, Kirsten E. Lyke, Benjamin Mordmueller, Peter G. Kremsner, Mahamadou S. Sissoko, Sarah Healy, Patrick E. Duffy, Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, Salim Abdulla, Maxmillian Mpina, Sodiomon B. Sirima, Matthew B. Laurens, Laura C. Steinhardt, Martina Oneko, MingLin Li, Tooba Murshedkar, Peter F. Billingsley, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman
Summary: Females aged 11 and above produced significantly higher levels of antibodies after receiving malaria vaccine compared to males, but this did not result in better protection for females. Protection levels after vaccination were equivalent between males and females.
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu, Xiawei Wei
Summary: A correction to this paper has been published.
Article
Biophysics
Luana Barbosa Correa, Suyene Rocha Pinto, Luciana Magalhaes Rebelo Alencar, Sotiris Missailidis, Elaine Cruz Rosas, Maria das Gracas Muller de Oliveira Henriques, Ralph Santos-Oliveira
Summary: A nanoaptamer anti-MUC1/Y was developed and evaluated as a nanoagent for rheumatoid arthritis treatment, showing high entrapment efficacy and significant therapeutic effects, especially at low doses. The results confirm the applicability of this nanosystem for RA treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Parasitology
Xin Zhuo Zhang, Wen Wen Yue, Sheng Jie Bai, Hui Nan Hao, Yan Yan Song, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang
Summary: This study explored the potential of TsE as a vaccine target for Trichinella infection. Oral vaccination of mice with TsE DNA induced a mixed immune response and provided significant immune protection against T. spiralis larval challenge. This protection was likely mediated by the production of intestinal mucus, specific antibodies, and the secretion of certain cytokines.
Article
Immunology
Jorge A. Soto, Nicolas M. S. Galvez, Gaspar A. Pacheco, Gisela Canedo-Marroquin, Susan M. Bueno, Alexis M. Kalergis
Summary: A single low dose of rBCG-P was found to induce a protective immune response in mice, reducing neutrophil counts and viral loads in the lungs during hMPV infection. This immune response involved various cell population changes and resulted in a robust humoral response, ultimately providing protection against hMPV-induced disease in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Respiratory System
Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevao, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger
Summary: Mycoplasma pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Abdol Sattar Pagheh, Ahmad Daryani, Paria Alizadeh, Hadi Hassannia, Sonia M. Rodrigues Oliveira, Tohid Kazemi, Fatemeh Rezaei, Maria de Lourdes Pereira, Ehsan Ahmadpour
Summary: This study evaluated the immune responses induced by a pcGRA14 + pcROP13 DNA vaccine cocktail in BALB/c mice. The vaccine significantly increased the production of specific antibodies and cytokines against toxoplasmosis, providing effective protection against T. gondii infection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Immunology
Youbo Shi, Jianbing Li, Weili Yang, Jia Chen
Summary: This study demonstrates that TgGRA35, TgGRA42, and TgGRA43 are potential vaccine candidates against Toxoplasma gondii infection, and the three-gene DNA vaccine cocktail provides the strongest protection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Erandi Velarde de la Cruz, Lingyun Wang, Deepanwita Bose, Sailaja Gangadhara, Robert L. Wilson, Rama R. Amara, Pamela A. Kozlowski, Anna Aldovini
Summary: The study evaluated a SHIV mucosal immunization in Rhesus macaques, showing that SHIVBG505-OPV immunization stimulated more significant systemic cell-mediated responses, but antibody responses were disappointing. There were no significant differences in post-infection viral loads between groups post-challenge, but the vaccinated groups had more significant preservation of Th17 CD4+ T cells in both blood and rectal mucosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Guang Wu, Lan Li, Mengnan Liu, Chunyan Chen, Guangze Wang, Zewei Jiang, Yaqian Qin, Licai He, Hongzhi Li, Jiawei Cao, Haihua Gu
Summary: The generated HzMUC1-ADC demonstrated promising targeted therapy potential for pancreatic cancer, as it inhibited tumor cell growth, induced apoptosis, and significantly reduced xenograft tumor growth in vivo.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Zenan Zhang, Hongyue Zhou, Yu Liu, Jia Ren, Jingjing Wang, Qianyu Sang, Yue Lan, Yixuan Wu, Hongyan Yuan, Weihua Ni, Guixiang Tai
Summary: The study demonstrated that combination immunotherapy with MUC1-MBP vaccine and α-PD1 could enhance the anti-tumor efficacy by boosting CD8(+)T cells mediated anti-tumor cellular immunity and decreasing the number of immunosuppressive cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Dan Shao, Fei Su, Xueyu Zou, Jie Lu, Sitong Wu, Ruijun Tian, Dongmei Ran, Zhiyong Guo, Dayong Jin
Summary: Lung adenocarcinoma is the most common type of lung cancer, and pixel-level labeling can assist pathologists in tumor grading. By manually annotating a dataset and using a data stitching strategy, a framework for lung adenocarcinoma pathology analysis was developed, which accurately labels the histologic patterns of lung adenocarcinoma.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Langping Tu, Kefan Wu, Yongshi Luo, Enhui Wang, Jun Yuan, Jing Zuo, Ding Zhou, Bin Li, Jiajia Zhou, Dayong Jin, Hong Zhang
Summary: Relatively low efficiency is the bottleneck for the application of lanthanide-doped upconversion nanoparticles. The high-level doping strategy realized in recent years has not improved the efficiency as much as expected. This study combines theoretical simulation and spectroscopy to elucidate the role of cross relaxation (CR) in the upconversion process and demonstrates that inhibiting CR significantly improves upconversion efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Yuan Liu, Gungun Lin, Mariana Medina-Sanchez, Maria Guix, Denys Makarov, Dayong Jin
Summary: With advanced biomedical theragnosis and bioengineering tools, smart and soft responsive microstructures and nanostructures have been developed that can change shapes and convert external power into mechanical actions. This article surveys the progress in designing responsive polymer-particle nanocomposites, leading to the development of smart shapemorphing microscale robotic devices. The use of magnetic fields for tether-free control enables penetration of biological tissues, and future fabrication techniques will be crucial for integrating nanoscale material functionalities into microscale robots.
Article
Chemistry, Multidisciplinary
Aditya Tripathi, Anastasiia Zalogina, Jiayan Liao, Matthias Wurdack, Eliezer Estrecho, Jiajia Zhou, Dayong Jin, Sergey S. Kruk, Yuri Kivshar
Summary: We demonstrate the effect of spin-momentum locking on upconversion photoluminescence emitted from rare-earth doped nanocrystals coupled to a phase-gradient dielectric metasurface. Different directionalities for left and right circular polarized light are observed, which can be attributed to the photonic Rashba effect that leads to a spin-dependent splitting of emitted light in momentum space.
Article
Chemistry, Multidisciplinary
Yongtao Liu, Jiajia Zhou, Shihui Wen, Fan Wang, Hongjun Wu, Qian Chen, Chao Zuo, Dayong Jin
Summary: Multiphoton upconversion super-resolution microscopy (MPUM) is a promising imaging modality that achieves increased resolution and penetration depth through the use of nonlinear near-infrared emission light. However, high excitation power is required for emission saturation, leading to increased phototoxicity. In this study, the authors propose a simple on-chip mirror design that allows for nonlinear saturation emission under low excitation power. This method significantly decreases the excitation power and enables a lateral resolution of around 35 nm in imaging single nanoparticles on-chip. The findings offer a straightforward solution for enhancing super-resolution imaging using pre-designed on-chip devices.
Article
Biochemical Research Methods
Shuang Fu, Wei Shi, Tingdan Luo, Yingchuan He, Lulu Zhou, Jie Yang, Zhichao Yang, Jiadong Liu, Xiaotian Liu, Zhiyong Guo, Chengyu Yang, Chao Liu, Zhen-li Huang, Jonas Ries, Mingjie Zhang, Peng Xi, Dayong Jin, Yiming Li
Summary: We propose a deep-learning method for precise localization of spatially variant point emitters, covering the full chip of a modern sCMOS camera. By using a graphic processing unit-based vectorial point spread function fitter, we accurately model the spatially variant PSF of a high numerical aperture objective in the entire field of view. Combined with deformable mirror-based optimal PSF engineering, we demonstrate high-accuracy three-dimensional single-molecule localization microscopy over a large volume, enabling imaging of mitochondria and nuclear pore complexes in entire cells without hardware scanning, with a 100-fold increase in throughput compared to existing techniques.
Editorial Material
Materials Science, Multidisciplinary
Jun Lin, Bengang Xing, Dayong Jin
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Analytical
Gungun Lin, Jawairia Umar Khan, Sareh Zhand, Yuan Liu, Dayong Jin
Summary: Researchers have developed a modular hydrogel membrane carrier with composite DNAzymes for rapid and highly sensitive detection of pathogenic bacteria gene target analytes. By incorporating composite DNAzymes into a polymer network, the researchers were able to release the DNAzymes to cleave RNA reporter probes and generate fluorescence, achieving quantitative assay performance. The work represents a significant advancement in the development of a versatile pathogenic bacteria testing platform. Overall, the importance of this research is 9 out of 10.
ANALYTICAL CHEMISTRY
(2023)
Correction
Chemistry, Analytical
Sareh Zhand, Ying Zhu, Hojjatollah Nazari, Mohammad Sadraeian, Majid Ebrahimi Warkiani, Dayong Jin
ANALYTICAL CHEMISTRY
(2023)
Article
Optics
Shui-Jing Tang, Mingjie Zhang, Jialve Sun, Jia-Wei Meng, Xiao Xiong, Qihuang Gong, Dayong Jin, Qi-Fan Yang, Yun-Feng Xiao
Summary: Researchers demonstrate real-time measurement of natural vibrations of single mesoscopic particles using photoacoustic excitation and acoustic coupling to an optical microresonator for readout. This technology extends the reach of vibrational spectroscopy and is applied for biomechanical fingerprinting of microorganisms at the single-cell level.
Article
Multidisciplinary Sciences
Chao Mi, Xun Zhang, Chengyu Yang, Jianqun Wu, Xinxin Chen, Chenguang Ma, Sitong Wu, Zhichao Yang, Pengzhen Qiao, Yang Liu, Weijie Wu, Zhiyong Guo, Jiayan Liao, Jiajia Zhou, Ming Guan, Chao Liang, Chao Liu, Dayong Jin
Summary: Researchers have developed a high-resolution near-infrared-II (NIR-II) imaging method for non-invasive diagnosis of skeletal disorders. By using lanthanide-doped nanocrystals, they were able to passively target the bone marrow and achieve effective bone imaging for over two months. The NIR-II imaging technique showed comparable results to X-ray imaging and could also diagnose early onset inflammation in rheumatoid arthritis.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Yue Cong, Bingyang Shi, Yiqing Lu, Shihui Wen, Roger Chung, Dayong Jin
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Gungun Lin, Jawairia Umar Khan, Sareh Zhand, Yuan Liu, Dayong Jin
Summary: This study presents a modular hydrogel membrane carrier incorporated with composite DNAzymes for rapid and highly sensitive detection of pathogenic bacteria gene targets. The composite DNAzymes are incorporated into polyethylene glycol diacrylate polymer networks, allowing for the cleavage of RNA substrate components to generate fluorescence. By modulating the morphology, composition, and microporous structures of the DNAzyme carriers, quantitative assay performance is achieved. This work represents an important advancement in the development of a generic, isothermal, and protein enzyme-free pathogenic bacteria testing platform technology.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Fu Zou, Yuanhua Liu, Zelyu Chen, Zhanghao Karl, Dayong Jin
Summary: This paper introduces a lightweight network FRUNet based on U-Net, which combines the advantages of Fourier Channel Attention (FCA Block) and Residual unit to improve image segmentation accuracy. FCA Block automatically assigns the weight of learned frequency information to the spatial domain, paying more attention to the precise high-frequency information of diverse biomedical images. The combination of FCA and U-Net is studied, with the skip connection of U-Net fusing encoder information with the decoder. Extensive experimental results show that FRUNet outperforms other advanced medical image segmentation methods in terms of network parameters and accuracy, particularly excelling in pathological section segmentation of nuclei and glands.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zayakhuu Gerelkhuu, Haribalan Perumalsamy, Mahnaz Maddahfar, Dayong Jin, Jaewoo Song, Tae Hyun Yoon
Summary: In order to promote the use of lanthanide-doped upconversion nanoparticles (UCNPs) in various biomedical applications, it is important to assess their toxicity comprehensively, including their cellular association and interactions with human immune cells. Recent advancements in high-throughput single-cell technologies have enabled us to gain a better understanding of the complex interactions between nanoparticles and human immune cells. In this study, we used a single-cell based mass cytometry technique to investigate the heterogeneous interactions of Yb3+/Er3+-doped NaYF4 UCNPs with human peripheral blood mononuclear cells (hPBMCs). The study demonstrated a new innovative approach to understanding the heterogeneous interactions of conventional nanomaterials with complex human immune systems, which will facilitate the safe implementation of nanomaterials in biomedical applications.
ENVIRONMENTAL SCIENCE-NANO
(2023)