Utilizing diversity-oriented synthesis in antimicrobial drug discovery

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

(2014) Björn Over et al.   JOURNAL OF MEDICINAL CHEMISTRY

Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

(2013) Natalie J. Spillman et al.   Cell Host & Microbe

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Diversity-Oriented Synthesis Yields a New Drug Lead for Treatment of Chagas Disease

(2013) Sivaraman Dandapani et al.   ACS Medicinal Chemistry Letters

The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector

(2012) J. C. van Pelt-Koops et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case

(2012) Thierry Kogej et al.   DRUG DISCOVERY TODAY

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization

(2012) Mark E. Fitzgerald et al.   ACS Combinatorial Science

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression

(2011) Ken Dower et al.   ANTIVIRAL RESEARCH

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

(2011) Tim Luker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

(2011) Connor O’Brien et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

(2011) K. Dower et al.   JOURNAL OF VIROLOGY

Gold Catalyzed Cyclization of Alkyne-Tethered Dihydropyrimidones

(2011) Lauren E. Brown et al.   ORGANIC LETTERS

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

(2011) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions

(2011) Bhaumik A. Pandya et al.   TETRAHEDRON

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

(2011) Richard W. Heidebrecht et al.   ACS Medicinal Chemistry Letters

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

(2010) Bryan K. S. Yeung et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

(2010) Lisa A. Marcaurelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chagas disease 101

(2010) Julie Clayton   NATURE

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

(2010) Sivaraman Dandapani et al.   Nature Chemical Biology

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

(2009) R. Jordan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

(2009) J. Huggins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The discovery of antibacterial agents using diversity-oriented synthesis

(2009) Warren R. J. D. Galloway et al.   CHEMICAL COMMUNICATIONS

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis

(2008) Gemma L. Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes

(2008) Eric H. Ekland et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION