Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

Genomewide Scan Reveals Amplification ofmdr1as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

(2011) Sofia Borges et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

(2011) Sachel Mok et al.   BMC GENOMICS

Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area

(2011) Jianping Song et al.   MALARIA JOURNAL

Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

(2011) Andrea Codd et al.   MALARIA JOURNAL

Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance

(2011) Maria Isabel Veiga et al.   PLoS One

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

A Research Agenda for Malaria Eradication: Diagnoses and Diagnostics

(2011)   PLOS MEDICINE

A Research Agenda for Malaria Eradication: Drugs

(2011)   PLOS MEDICINE

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigations into the Role of the Plasmodium falciparum SERCA (PfATP6) L263E Mutation in Artemisinin Action and Resistance

(2010) S. G. Valderramos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum

(2010) M. Chavchich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

(2010) Dorothee Beez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Decreased In Vitro Susceptibility of Plasmodium falciparum Isolates to Artesunate, Mefloquine, Chloroquine, and Quinine in Cambodia from 2001 to 2007

(2010) P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum

(2010) M. Imwong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro

(2010) N. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

(2010) Paul Hunt et al.   BMC GENOMICS

Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia

(2010) Harald Noedl et al.   CLINICAL INFECTIOUS DISEASES

A call to action: addressing the challenge of artemisinin-resistant malaria

(2010) Stephen P Kachur et al.   Expert Review of Anti-Infective Therapy

High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

(2010) Tim J. C. Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

Artemisinin‐Induced Dormancy inPlasmodium falciparum: Duration, Recovery Rates, and Implications in Treatment Failure

(2010) Franka Teuscher et al.   JOURNAL OF INFECTIOUS DISEASES

In Vivo Parasitological Measures of Artemisinin Susceptibility

(2010) Kasia Stepniewska et al.   JOURNAL OF INFECTIOUS DISEASES

Universal access to malaria medicines: innovation in financing and delivery

(2010) Olusoji Adeyi et al.   LANCET

Malaria in children

(2010) Jane Crawley et al.   LANCET

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial

(2010) Antoinette K Tshefu et al.   LANCET

Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

(2010) Ngo V Thanh et al.   MALARIA JOURNAL

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Intrahost modeling of artemisinin resistance in Plasmodium falciparum

(2010) S. Saralamba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria's Drug Miracle in Danger

(2010) M. Enserink   SCIENCE

Monitoring antimalarial resistance: launching a cooperative effort

(2010) Carol Hopkins Sibley et al.   TRENDS IN PARASITOLOGY

Artemisinins and the biological basis for the PfATP6/SERCA hypothesis

(2010) Sanjeev Krishna et al.   TRENDS IN PARASITOLOGY

Pitfalls in new artemisinin-containing antimalarial drug development

(2010) Ronan Jambou et al.   TRENDS IN PARASITOLOGY

How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance

(2010) Ian Hastings   TRENDS IN PARASITOLOGY

Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

(2010) Xavier C. Ding et al.   TRENDS IN PARASITOLOGY

Sensitivity to artemisinin, mefloquine and quinine of Plasmodium falciparum in northwestern Thailand

(2010) Felix Hüttinger et al.   WIENER KLINISCHE WOCHENSCHRIFT

Drug-Resistant Malaria: The Era of ACT

(2010) Jessica T. Lin et al.   Current Infectious Disease Reports

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Disruption of aPlasmodium falciparumMultidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

(2009) Dipak Kumar Raj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia

(2009) Richard J Maude et al.   MALARIA JOURNAL

A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria

(2009) Stéphane Picot et al.   MALARIA JOURNAL

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum

(2009) Guangan Hu et al.   NATURE BIOTECHNOLOGY

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment

(2009) Verena Ilona Carrara et al.   PLoS One

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia

(2008) Paul N Newton et al.   PLOS MEDICINE