Journal
FUTURE MEDICINAL CHEMISTRY
Volume 2, Issue 6, Pages 965-973Publisher
FUTURE SCI LTD
DOI: 10.4155/FMC.10.190
Keywords
-
Categories
Funding
- EMBO
- AACR
Ask authors/readers for more resources
Embryonic stem cells (ESCs) are a promising cell source for regenerative medicine and transplantation therapy. ESCs are able to self-renew indefinitely in culture; however, the ability to differentiate ESCs into specific cell lineages is key to exploiting their therapeutic potential. Cell-based phenotypic and reporter-based screens have been used to identify small molecules that selectively promote ESC differentiation into a variety of cell lineages. Not only will such molecules facilitate the clinical applications of stem cells, the detailed study of their mechanism is providing new insights into the biology that regulates ESC self-renewal and differentiation. In this article we discuss key issues, challenges and opportunities in the application of this chemical approach to stem cell biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available