Peptides as the next generation of anti-infectives

Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

(2012) Varun Dewan et al.   ACS Chemical Biology

Analytical Characterization of an Orally-Delivered Peptide Pharmaceutical Product

(2012) Wayne P. Kelley et al.   ANALYTICAL CHEMISTRY

Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Delivery

(2012) Christopher J. Morris et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease

(2012) Christoph Nitsche et al.   ANTIVIRAL RESEARCH

Salivary concentration of the antimicrobial peptide LL-37 in children

(2012) Sotiria Davidopoulou et al.   ARCHIVES OF ORAL BIOLOGY

Antibacterial Peptides “Bacteriocins”: An Overview of Their Diverse Characteristics and Applications

(2012) MAMI NISHIE et al.   BIOCONTROL SCIENCE

Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis

(2012) Diego C Rossi et al.   BMC MICROBIOLOGY

Mechanisms and Modifications of Naturally Occurring Host Defense Peptides for Anti-HIV Microbicide Development

(2012) Colleen R. Eade et al.   CURRENT HIV RESEARCH

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, and other Gram-positives in healthcare

(2012) David P. Calfee   CURRENT OPINION IN INFECTIOUS DISEASES

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review

(2012) Sepideh Elyasi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Advances in hepatitis C virus vaccines, part two: advances in hepatitis C virus vaccine formulations and modalities

(2012) Farzin Roohvand et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A human claudin-1-derived peptide inhibits hepatitis C virus entry

(2012) Youhui Si et al.   HEPATOLOGY

Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies

(2012) Y. Cai et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4αin Vitroandin Vivo

(2012) Zhenhuan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide Inhibitors of Viral Assembly: A Novel Route to Broad-Spectrum Antivirals

(2012) Karim M. ElSawy et al.   Journal of Chemical Information and Modeling

A novel family of peptides with potent activity against influenza A viruses

(2012) M. Q. Nicol et al.   JOURNAL OF GENERAL VIROLOGY

Hapivirins and Diprovirins: Novel  -Defensin Analogs with Potent Activity against Influenza A Virus

(2012) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Pediocins: The bacteriocins of Pediococci. Sources, production, properties and applications

(2012) Maria Papagianni et al.   Microbial Cell Factories

Daptomycin: A Review of Properties, Clinical Use, Drug Delivery and Resistance

(2012) C. Vilhena et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26

(2012) Alberto Muñoz et al.   MOLECULAR MICROBIOLOGY

Biophysical Property and Broad Anti-HIV Activity of Albuvirtide, a 3-Maleimimidopropionic Acid-Modified Peptide Fusion Inhibitor

(2012) Huihui Chong et al.   PLoS One

Identification of a Novel Antifungal Peptide with Chitin-Binding Property from Marine Metagenome

(2012) Muthuirulan Pushpanathan et al.   PROTEIN AND PEPTIDE LETTERS

Novel Natural Food Antimicrobials

(2012) Vijay K. Juneja et al.   Annual Review of Food Science and Technology

Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)

(2011) Lenka Monincová et al.   AMINO ACIDS

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Inhibition of Herpes Simplex Virus Type 1 and Type 2 Infections by Peptide-Derivatized Dendrimers

(2011) Anna Luganini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of the Minimal Active Sequence of an Anti-Influenza Virus Peptide

(2011) Jeremy C. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Properties of MX-2401, an Expanded-Spectrum Lipopeptide Active in the Presence of Lung Surfactant

(2011) Dominique Dugourd et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective Membrane Disruption: Mode of Action of C16G2, a Specifically Targeted Antimicrobial Peptide

(2011) Christopher W. Kaplan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Efficacy of Halocidin-Derived Peptide HG1 in a Mouse Model of Surgical Wound Infection with Methicillin-ResistantStaphylococcus aureus

(2011) Young Shin Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endocytosis-Mediated Vacuolar Accumulation of the Human ApoE Apolipoprotein-Derived ApoEdpL-W Antimicrobial Peptide Contributes to Its Antifungal Activity in Candida albicans

(2011) Tristan Rossignol et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease

(2011) Jennifer M. Ritchie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

(2011) Yan Q. Xiong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-Resistant Gram-Negative Bacteria

(2011) Chao-Dong Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide derived from anti-idiotypic single-chain antibody is a potent antifungal agent compared to its parent fungicide HM-1 killer toxin peptide

(2011) M. Enamul Kabir et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sensitivity of Saccharomyces cerevisiae to the cell-penetrating antifungal peptide PAF26 correlates with endogenous nitric oxide (NO) production

(2011) Lourdes Carmona et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air–water interface

(2011) Rondinelli D. Herculano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Multifaceted action of Fuzeon as virus–cell membrane fusion inhibitor

(2011) Avraham Ashkenazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The antimicrobial peptide arenicin-1 promotes generation of reactive oxygen species and induction of apoptosis

(2011) Jaeyong Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus

(2011) Carlos López-Abarrategui et al.   BIOCHIMIE

Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5

(2011) Han-Ning Huang et al.   BIOMATERIALS

Clinical Efficacy of a Specifically Targeted Antimicrobial Peptide Mouth Rinse: Targeted Elimination of Streptococcus mutans and Prevention of Demineralization

(2011) R. Sullivan et al.   CARIES RESEARCH

Bacterial resistance mechanisms against host defense peptides

(2011) Tomaz Koprivnjak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rational Design of Peptides with Anti-HCV/HIV Activities and Enhanced Specificity

(2011) Gui-Rong Li et al.   Chemical Biology & Drug Design

Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus

(2011) Ana Montero et al.   CHEMISTRY & BIOLOGY

A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro

(2011) Maciej Maselko et al.   CURRENT HIV RESEARCH

Cationic antimicrobial peptides in clinical development, with special focus on thanatin and heliomicin

(2011) E. Andrès   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

(2011) Randal Eckert   Future Microbiology

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes

(2011) Emily Happy Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits

(2011) M. Wiig et al.   Journal of Hand Surgery-European Volume

A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption

(2011) Johan Isaksson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial

(2011) Sharon Elad et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Dermaseptin 01 as antimicrobial peptide with rich biotechnological potential: study of peptide interaction with membranes containing Leishmania amazonensis lipid-rich extract and membrane models

(2011) Luiz C. Salay et al.   JOURNAL OF PEPTIDE SCIENCE

Diversity of Coding Sequences and Gene Structures of the Antifungal Peptide Mytimycin (MytM) from the Mediterranean Mussel, Mytilus galloprovincialis

(2011) Molruedee Sonthi et al.   MARINE BIOTECHNOLOGY

Current Concepts in Antimicrobial Therapy Against Select Gram-Positive Organisms: Methicillin-ResistantStaphylococcus aureus, Penicillin-Resistant Pneumococci, and Vancomycin-Resistant Enterococci

(2011) Ana Maria Rivera et al.   MAYO CLINIC PROCEEDINGS

Antimicrobial peptides in the duodenum at the acute and convalescent stages in patients with diarrhea due to Vibrio cholerae O1 or enterotoxigenic Escherichia coli infection

(2011) Tahmina Shirin et al.   MICROBES AND INFECTION

Determination of a new antibacterial peptide S-thanatin in rat plasma by an indirected-ELISA

(2011) Guoqiu Wu et al.   PEPTIDES

Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation

(2011) Santi M. Mandal et al.   PEPTIDES

Discovery and development of a synthetic peptide derived from lactoferrin for clinical use

(2011) Carlo P.J.M. Brouwer et al.   PEPTIDES

HSV Neutralization by the Microbicidal Candidate C5A

(2011) Lot de Witte et al.   PLoS One

Rationally Designed Interfacial Peptides Are Efficient In Vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity

(2011) Rebeca Bocanegra et al.   PLoS One

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Peptide inhibition of human cytomegalovirus infection

(2011) Lilia I Melnik et al.   Virology Journal

Bioanalytical approaches to analyzing peptides and proteins by LC–MS/MS

(2011) Matthew Ewles et al.   Bioanalysis

Airway-Rehydrating Agents for the Treatment of Cystic Fibrosis: Past, Present, and Future

(2010) Rebecca S Pettit et al.   ANNALS OF PHARMACOTHERAPY

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

(2010) Kerstin Wunderlich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production

(2010) Xiao-Ben Pan et al.   ANTIVIRAL RESEARCH

Antifungal properties and mode of action of psacotheasin, a novel knottin-type peptide derived from Psacothea hilaris

(2010) Bomi Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Battle and balance at mucosal surfaces – The story of Shigella and antimicrobial peptides

(2010) Gudmundur Hrafn Gudmundsson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Chemotherapy in Hodgkin’s Lymphoma

(2010) Pamela Seam et al.   CANCER JOURNAL

Curvularides A-E: Antifungal Hybrid Peptide-Polyketides from the Endophytic Fungus Curvularia geniculata

(2010) Porntep Chomcheon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Challenges in Anti‐Infective Development in the Era of Bad Bugs, No Drugs: A Regulatory Perspective Using the Example of Bloodstream Infection as an Indication

(2010) Helen W. Boucher   CLINICAL INFECTIOUS DISEASES

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

(2010) B. P. Howden et al.   CLINICAL MICROBIOLOGY REVIEWS

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

Functional role of charged residues in drosomycin, a Drosophila antifungal peptide

(2010) Zhenting Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Enfuvirtide: from basic investigations to current clinical use

(2010) Véronique Joly et al.   EXPERT OPINION ON PHARMACOTHERAPY

Clostridium difficileinfection: update on emerging antibiotic treatment options and antibiotic resistance

(2010) Dhara Shah et al.   Expert Review of Anti-Infective Therapy

From optical bench to cageside: intravital microscopy on the long road to rational vaccine design

(2010) Heather D. Hickman et al.   IMMUNOLOGICAL REVIEWS

The continuing crisis in antibiotic resistance

(2010) G.L. French   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiparasitic activity of the antimicrobial peptide HbβP-1, a member of the β-haemoglobin peptide family

(2010) A J Ullal et al.   JOURNAL OF FISH DISEASES

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Formulated Microbicide RC-101 Was Safe and Antivirally Active Following Intravaginal Application in Pigtailed Macaques

(2010) Alexander M. Cole et al.   PLoS One

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

High Cerebrospinal Fluid (CSF) Penetration and Potent Bactericidal Activity in CSF of NZ2114, a Novel Plectasin Variant, during Experimental Pneumococcal Meningitis

(2009) C. Ostergaard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fungicidal effect of antimicrobial peptide arenicin-1

(2009) Cana Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bombinins, antimicrobial peptides from Bombina species

(2009) Maurizio Simmaco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional and biochemical analysis of a key series of ramoplanin analogues

(2009) Xiao Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro

(2009) Qing-long Liang et al.   BIOTECHNOLOGY LETTERS

Memories that last forever: strategies for optimizing vaccine T-cell memory

(2009) J. D. Ahlers et al.   BLOOD

The interaction of an antiparasitic peptide active against African Sleeping Sickness with cell membrane models

(2009) Cauê P. Pascholati et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Colistin in the 21st century

(2009) Roger L Nation et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Development of an ELISA for quantification of the antimicrobial peptide piscidin 4 and its application to assess stress in fish

(2009) J. Corrales et al.   FISH & SHELLFISH IMMUNOLOGY

Drosomycin, an essential component of antifungal defence inDrosophila

(2009) Z-T. Zhang et al.   INSECT MOLECULAR BIOLOGY

Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide

(2009) Hong Bing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quality specifications for peptide drugs: a regulatory-pharmaceutical approach

(2009) Valentijn Vergote et al.   JOURNAL OF PEPTIDE SCIENCE

End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing

(2009) Mukesh Pasupuleti et al.   PLoS One

Novel Antimicrobial Peptides Isolated from Skin Secretions of the Mexican Frog Hyla eximia

(2009) Oscar Villa-Hernandez et al.   PROTEIN AND PEPTIDE LETTERS

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections

(2008) T. R. Fritsche et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Efficacy of R-Type Pyocins towards Pseudomonas aeruginosa in a Murine Peritonitis Model

(2008) D. Scholl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei

(2008) R. B. G. Arrighi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Control of cell selectivity of antimicrobial peptides

(2008) Katsumi Matsuzaki   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Impact of Antibiotic Resistance in Gram‐Negative Bacilli on Empirical and Definitive Antibiotic Therapy

(2008) David L. Paterson   CLINICAL INFECTIOUS DISEASES

Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream

(2008) Benjamin A. Lipsky et al.   CLINICAL INFECTIOUS DISEASES

De novo designed synthetic mimics of antimicrobial peptides

(2008) Richard W Scott et al.   CURRENT OPINION IN BIOTECHNOLOGY

The roles of cathelicidin LL-37 in immune defences and novel clinical applications

(2008) Anastasia Nijnik et al.   CURRENT OPINION IN HEMATOLOGY

Antimicrobial activity of omiganan pentahydrochloride tested against contemporary bacterial pathogens commonly responsible for catheter-associated infections

(2008) T. R. Fritsche et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Gene expression, antiparasitic activity, and functional evolution of the drosomycin family

(2008) Caihuan Tian et al.   MOLECULAR IMMUNOLOGY

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES

Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals

(2007) S.E. Löfgren et al.   EXPERIMENTAL PARASITOLOGY