Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

Systematic Approach to Optimizing Specifically Targeted Antimicrobial Peptides against Streptococcus mutans

(2010) J. He et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

(2010) D. Knappe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

(2010) Robert Bucki et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis

(2010) Huaying Wang et al.   BIOMATERIALS

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

(2010) Christian A. Olsen et al.   CHEMBIOCHEM

Antimicrobial peptides: General overview and clinical implications in human health and disease

(2010) Eduardo Guaní-Guerra et al.   CLINICAL IMMUNOLOGY

Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control

(2010) Anselmo Jesus Otero-González et al.   FASEB JOURNAL

Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1

(2010) Seicho Makihira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Hydrophobicity on the Interaction between Antimicrobial Peptides and Poly(acrylic acid) Microgels

(2010) Helena Bysell et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The effects of tryptophan and hydrophobicity on the structure and bioactivity of novel indolicidin derivatives with promising pharmaceutical potential

(2010) Aaron P. Podorieszach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice

(2010) Wei Zhang et al.   PEPTIDES

Membrane Permeabilization by Multivalent Anti-Microbial Peptides

(2010) Roland Pieters et al.   PROTEIN AND PEPTIDE LETTERS

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non‐cariogenic Oral Biofilms and Reduces Subsequent Infection

(2010) Li‐na Li et al.   International Journal of Oral Science

Evaluation of WLBU2 Peptide and 3-O-Octyl-sn-Glycerol Lipid as Active Ingredients for a Topical Microbicide Formulation Targeting Chlamydia trachomatis

(2009) M. C. Skinner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design of Nontoxic Analogues of Cathelicidin-Derived Bovine Antimicrobial Peptide BMAP-27: The Role of Leucine as Well as Phenylalanine Zipper Sequences in Determining Its Toxicity

(2009) Aqeel Ahmad et al.   BIOCHEMISTRY

Binding of amphipathic α-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L

(2009) Ajay K. Mahalka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification

(2009) Maria Luisa Mangoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Can antimicrobial peptides scavenge around a cell in less than a second?

(2009) Eduard Y. Chekmenev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Divorcing folding from function: How acylation affects the membrane-perturbing properties of an antimicrobial peptide

(2009) Brian Vad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Incorporation of antimicrobial compounds in mesoporous silica film monolith

(2009) Isabel Izquierdo-Barba et al.   BIOMATERIALS

Controlling the release of peptide antimicrobial agents from surfaces

(2009) Anita Shukla et al.   BIOMATERIALS

Membrane interactions of antimicrobial β-peptides: The role of amphipathicity versus secondary structure induction

(2009) Kristopher Hall et al.   BIOPOLYMERS

Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics

(2009) Tatsushi Mogi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptoid-Peptide Hybrid Backbone Architectures

(2009) Christian A. Olsen   CHEMBIOCHEM

Design and Characterization of an Acid-Activated Antimicrobial Peptide

(2009) Lina Li et al.   Chemical Biology & Drug Design

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

(2009) Antony N. Appleyard et al.   CHEMISTRY & BIOLOGY

Synthetic Mimics of Antimicrobial Peptides-A Versatile Ring-Opening Metathesis Polymerization Based Platform for the Synthesis of Selective Antibacterial and Cell-Penetrating Polymers

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies

(2009) Rohit K. Sharma et al.   ChemMedChem

Investigation of the Cytotoxicity of Antimicrobial Peptide P40 on Eukaryotic Cells

(2009) Rodrigo A. Vaucher et al.   CURRENT MICROBIOLOGY

New approaches in peptide antibiotics

(2009) Martti Vaara   CURRENT OPINION IN PHARMACOLOGY

Anionic Antimicrobial Peptides from Eukaryotic Organisms

(2009) Frederick Harris et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides

(2009) Pierre Nicolas   FEBS Journal

N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins

(2009) Anton A. Polyansky et al.   FEBS LETTERS

Defensins as anti-inflammatory compounds and mucosal adjuvants

(2009) Karl G Kohlgraf et al.   Future Microbiology

Therapeutic challenges in the era of antibiotic resistance

(2009) Christopher Lee   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Design and activity of a ‘dual-targeted’ antimicrobial peptide

(2009) Jian He et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Dermaseptins and Magainins: Antimicrobial Peptides from Frogs' Skin—New Sources for a Promising Spermicides Microbicides—A Mini Review

(2009) Amira Zairi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lantibiotics: Diverse activities and unique modes of action

(2009) Sikder M. Asaduzzaman et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides

(2009) Terkel Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

(2009) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY

Antimicrobial Peptides as Model Molecules for the Development of Novel Antiviral Agents in Aquaculture

(2009) A. Falco et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides

(2009) Sarah Rachel Dennison et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fluorine—a new element in the design of membrane-active peptides

(2009) E. Neil G. Marsh et al.   Molecular BioSystems

Leishmanicidal Activity and Immobilization of dermaseptin 01 antimicrobial peptides in ultrathin films for nanomedicine applications

(2009) Maysa F. Zampa et al.   Nanomedicine-Nanotechnology Biology and Medicine

The chemistry and biology of LL-37

(2009) Matthew F. Burton et al.   NATURAL PRODUCT REPORTS

Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent

(2009) Lihong Liu et al.   Nature Nanotechnology

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

(2009) Manuel N. Melo et al.   NATURE REVIEWS MICROBIOLOGY

CAMP: a useful resource for research on antimicrobial peptides

(2009) Shaini Thomas et al.   NUCLEIC ACIDS RESEARCH

Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen

(2009) Hongqiang Liu et al.   ORGANIC LETTERS

End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing

(2009) Mukesh Pasupuleti et al.   PLoS One

Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics

(2009) Kwong-Fai Wong et al.   PROTEIN AND PEPTIDE LETTERS

Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009)

(2009) Ana Espinel-Ingroff   REVISTA IBEROAMERICANA DE MICOLOGIA

Bioactive peptides: signaling the future

(2009) K Fields et al.   Journal of Cosmetic Dermatology

Immobilization Reduces the Activity of Surface-Bound Cationic Antimicrobial Peptides with No Influence upon the Activity Spectrum

(2008) M. Bagheri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Lipopolypeptides Composed of Palmitoyl Di- and Tricationic Peptides:In Vitroandin VivoActivities, Self-Assembly to Nanostructures, and a Plausible Mode of Action†

(2008) Arik Makovitzki et al.   BIOCHEMISTRY

Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin

(2008) Lindsey M. Gottler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial peptide mimics for improved therapeutic properties

(2008) Shahar Rotem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Control of cell selectivity of antimicrobial peptides

(2008) Katsumi Matsuzaki   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alternating release of different bioactive molecules from a complexation polymer system

(2008) Ju Hyeong Jeon et al.   BIOMATERIALS

Design and synthesis of cyclic disulfide-bonded antibacterial peptides on the basis of the α helical domain of Tenecin 1, an insect defensin

(2008) Hye-sun Ahn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic mimics of antimicrobial peptides

(2008) Abhigyan Som et al.   BIOPOLYMERS

Antibacterial hydrogels of amino acid-based cationic amphiphiles

(2008) Sangita Roy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antimicrobial peptides: natural templates for synthetic membrane-active compounds

(2008) A. Giuliani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Sushi peptides: structural characterization and mode of action against Gram-negative bacteria

(2008) J. L. Ding et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N-Fmoc-Protected(α-Dipeptidoyl)Benzotriazoles for Efficient Solid-Phase Peptide Synthesis by Segment Condensation

(2008) Alan R. Katritzky et al.   Chemical Biology & Drug Design

Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream

(2008) Benjamin A. Lipsky et al.   CLINICAL INFECTIOUS DISEASES

The roles of cathelicidin LL-37 in immune defences and novel clinical applications

(2008) Anastasia Nijnik et al.   CURRENT OPINION IN HEMATOLOGY

Preparation and Characterization of Coacervate Microcapsules for the Delivery of Antimicrobial Oyster Peptides

(2008) Li Zhang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Are cationic antimicrobial peptides also ‘double-edged swords’?

(2008) Isaac Ginsburg et al.   Expert Review of Anti-Infective Therapy

RAPD: a database of recombinantly-produced antimicrobial peptides

(2008) Yifeng Li et al.   FEMS MICROBIOLOGY LETTERS

Targeted antimicrobial activity of a specific IgG–SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture

(2008) Michael R. Franzman et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms

(2008) K. Flemming et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Modification of Antimicrobial Peptide with Low Molar Mass Poly(ethylene glycol)

(2008) Genghui Zhang et al.   JOURNAL OF BIOCHEMISTRY

Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides

(2008) Ayman Hawrani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Antimicrobial Peptidomimetics with Therapeutic Potential

(2008) Bengt Erik Haug et al.   JOURNAL OF MEDICINAL CHEMISTRY

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics

(2008) Marco Cassone et al.   PEPTIDES

Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles

(2008) Anthony S. Ham et al.   PHARMACEUTICAL RESEARCH

Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains

(2007) Misagh Alipour et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS