JNK inhibitors as anti-inflammatory and neuroprotective agents

Novel roles for JNK1 in metabolism

(2016) Bengt F. Belgardt et al.   Aging-US

Axonal degeneration as a therapeutic target in the CNS

(2012) Paul Lingor et al.   CELL AND TISSUE RESEARCH

U.S. Food and Drug Administration Approval: Ruxolitinib for the Treatment of Patients with Intermediate and High-Risk Myelofibrosis

(2012) A. Deisseroth et al.   CLINICAL CANCER RESEARCH

Tofacitinib for the treatment of rheumatoid arthritis

(2012) Cristiano AF Zerbini et al.   Expert Review of Clinical Immunology

JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain

(2012) Lan-Wan Wang et al.   Journal of Neuroinflammation

Inhibition of JNK by a Peptide Inhibitor Reduces Traumatic Brain Injury–Induced Tauopathy in Transgenic Mice

(2012) Hien T. Tran et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Delayed Inhibition of c-Jun N-Terminal Kinase Worsens Outcomes after Focal Cerebral Ischemia

(2012) Y. Murata et al.   JOURNAL OF NEUROSCIENCE

Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity

(2012) Ulf Schulze-Topphoff et al.   PLoS One

The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis

(2012) Kirstin Reinecke et al.   PLoS One

Differential Requirement for c-Jun N-terminal Kinase 1 in Lung Inflammation and Host Defense

(2012) Jos Van der Velden et al.   PLoS One

JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling

(2012) Saida Abdelli et al.   PLoS One

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate

(2012) Anette Hübner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus-Kinase-Hemmer

(2012) E. Ostermeier et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell Migration

(2011) Tamer S. Kaoud et al.   ACS Chemical Biology

JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis

(2011) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Design, synthesis, and structure–activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

(2011) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

(2011) R. Jeffrey Neitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

(2011) Simeon Bowers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

(2011) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

(2011) Simeon Bowers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

(2011) Xinyi Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of JNK in Mammary Gland Development and Breast Cancer

(2011) C. Cellurale et al.   CANCER RESEARCH

Levodopa Activates Apoptosis Signaling Kinase 1 (ASK1) and Promotes Apoptosis in a Neuronal Model: Implications for the Treatment of Parkinson's Disease

(2011) Elizabeth A. Sabens Liedhegner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The bottleneck of JNK signaling: Molecular and functional characteristics of MKK4 and MKK7

(2011) Wiebke Haeusgen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

c-Jun N-terminal Kinase (JNK-1) Confers Protection against Brief but Not Extended Ischemia during Acute Myocardial Infarction

(2011) Jianqin Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Characterization of a Potent and Selective Dual ATP- and Substrate-Competitive Subnanomolar Bidentate c-Jun N-Terminal Kinase (JNK) Inhibitor

(2011) John L. Stebbins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor

(2011) Anne Vaslin et al.   JOURNAL OF NEUROCHEMISTRY

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

(2011) C. Cellurale et al.   MOLECULAR AND CELLULAR BIOLOGY

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria

(2011) Yi Zhao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay

(2011) Peter H. Reinhart et al.   NEUROBIOLOGY OF DISEASE

C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice

(2011) Kazuhiro Yoshimura et al.   NEUROSCIENCE RESEARCH

Activation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death

(2011) Meghana Tare et al.   PLoS One

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

(2010) Roy K. Hom et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors

(2010) Romain Noël et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

(2010) Gary D. Probst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats

(2010) Xu Chen et al.   BRAIN RESEARCH

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus

(2010) Giada Spigolon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Small Molecule JNK (c-Jun N-Terminal Kinase) Inhibitors

(2010) M. Arshad Siddiqui et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers

(2010) Chiara Ferrandi et al.   Multiple Sclerosis Journal

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model

(2010) Peila Chen et al.   PLoS One

The Role of JNK Proteins in Metabolism

(2010) S. N. Vallerie et al.   Science Translational Medicine

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

(2010) Guadalupe Sabio et al.   TRENDS IN BIOCHEMICAL SCIENCES

MAPK signaling in inflammation-associated cancer development

(2010) Pengyu Huang et al.   Protein & Cell

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

(2009) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

(2009) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

JNK inhibition and inflammation after cerebral ischemia

(2009) Corinne Benakis et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

(2009) Ted Kamenecka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific activities of individual c-Jun N-terminal kinases in the brain

(2009) W. Haeusgen et al.   NEUROSCIENCE

c-Jun N-Terminal Kinase 2 Deficiency Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction and Oxidative Stress

(2008) Elena Osto et al.   CIRCULATION

Blockage by SP600125 of Fc  Receptor-Induced Degranulation and Cytokine Gene Expression in Mast Cells is Mediated Through Inhibition of Phosphatidylinositol 3-Kinase Signalling Pathway

(2008) S. Tanemura et al.   JOURNAL OF BIOCHEMISTRY

All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

(2008) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes

(2008) Adeel Ijaz et al.   KIDNEY INTERNATIONAL

Inhibitors of c-Jun N-terminal kinases—JuNK no more?

(2007) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS