Therapeutic applications of PI3K inhibitors in cardiovascular diseases

Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity

(2014) R. Pincheira et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases

(2012) Alessandra Ghigo et al.   CIRCULATION

Anchoring Proteins as Regulators of Signaling Pathways

(2012) Alessia Perino et al.   CIRCULATION RESEARCH

Phosphoinositide 3-Kinase p110α Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

(2012) Kate L. Weeks et al.   Circulation-Heart Failure

Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

(2012) S. NYLANDER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

Role and regulation of phosphatidylinositol 3-kinase   in platelet integrin  2 1 signaling

(2011) A. Consonni et al.   BLOOD

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

(2011) Daniela Carnevale et al.   CARDIOVASCULAR RESEARCH

Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload–Induced Cardiac Failure

(2011) Federico Damilano et al.   CIRCULATION

Vascular Remodeling in Hypertension

(2011) Ernesto L. Schiffrin   HYPERTENSION

Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure

(2011) Ashley J. Waardenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL

(2011) Joshua J. Anzinger et al.   JOURNAL OF LIPID RESEARCH

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

(2011) Chia-Yen C. Wu et al.   PLoS One

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure

(2010) Ruby C.Y. Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

CAL-101, a p110  selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

(2010) B. J. Lannutti et al.   BLOOD

Involvement of Phosphoinositide 3-Kinase γ in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice

(2010) Mauro Siragusa et al.   CIRCULATION RESEARCH

Enhanced Ca 2+ -Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats

(2010) Young Mi Seok et al.   HYPERTENSION

Role of Phosphoinositide 3-Kinase α, Protein Kinase C, and L-Type Ca 2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility

(2010) Wenbin Liang et al.   HYPERTENSION

Impaired Peroxisome Proliferator-activated Receptor-γ Contributes to Phenotypic Modulation of Vascular Smooth Muscle Cells during Hypertension

(2010) Lili Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway

(2010) Bernhard J. Haubner et al.   PLoS One

Reduced Phosphoinositide 3-Kinase (p110α) Activation Increases the Susceptibility to Atrial Fibrillation

(2009) Lynette Pretorius et al.   AMERICAN JOURNAL OF PATHOLOGY

Absence of Akt1 Reduces Vascular Smooth Muscle Cell Migration and Survival and Induces Features of Plaque Vulnerability and Cardiac Dysfunction During Atherosclerosis

(2009) Carlos Fernández-Hernando et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Loss of Cardiac Phosphoinositide 3-Kinase p110α Results in Contractile Dysfunction

(2009) Zhongju Lu et al.   CIRCULATION

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

(2009) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

(2009) Yolanda Alvarez et al.   PLoS One

Twice upon a time: PI3K's secret double life exposed

(2009) Emilio Hirsch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Temporally controlled overexpression of cardiac-specific PI3Kα induces enhanced myocardial contractility—a new transgenic model

(2008) Naohiro Yano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

(2008) C. R. Schnell et al.   CANCER RESEARCH

Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells

(2008) Regine Heller et al.   CARDIOVASCULAR RESEARCH

Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes

(2008) Anne Fougerat et al.   CIRCULATION

Phosphatidylinositol 3-Kinase γ Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning

(2008) Kiwon Ban et al.   CIRCULATION RESEARCH

Phosphatidylinositol-3-Kinase-γ Is Integral to Homing Functions of Progenitor Cells

(2008) Emmanouil Chavakis et al.   CIRCULATION RESEARCH

Transforming Growth Factor   Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab

(2008) S. E. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Taming the PI3K team to hold inflammation and cancer at bay

(2008) Emilio Hirsch et al.   PHARMACOLOGY & THERAPEUTICS

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

(2008) T. L. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

(2007) Paolo Madeddu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY