Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

(2013) Frédéric Thuaud et al.   CHEMISTRY & BIOLOGY

Prohibitin and its rapidly emerging role as a biomarker of systemic malignancies—Reply

(2013) Feng Guo et al.   HUMAN PATHOLOGY

Prohibitin and its rapidly emerging role as a biomarker of systemic malignancies

(2013) Shailendra Kapoor   HUMAN PATHOLOGY

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

(2013) Houda Alachkar et al.   Journal of Hematology & Oncology

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

(2013) Jennifer M. Chambers et al.   ORGANIC LETTERS

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Dual Targeting of the Cyclin/Rb/E2F and Mitochondrial Pathways in Mantle Cell Lymphoma with the Translation Inhibitor Silvestrol

(2012) L. Alinari et al.   CLINICAL CANCER RESEARCH

Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes

(2012) C. R. Lucas et al.   JOURNAL OF IMMUNOLOGY

Flavaglines as Potent Anticancer and Cytoprotective Agents

(2012) Nigel Ribeiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors

(2012) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization

(2012) John A. Malona et al.   JOURNAL OF ORGANIC CHEMISTRY

Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

(2012) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

(2012) Neil J. Lajkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

eIF4F suppression in breast cancer affects maintenance and progression

(2012) Z Nasr et al.   ONCOGENE

Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein

(2012) C Jin et al.   ONCOGENE

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

(2012) L M Lindqvist et al.   Cell Death & Disease

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice

(2012) Sergio Di Marco et al.   Nature Communications

Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated by ABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells

(2011) Sneha V. Gupta et al.   AAPS Journal

Recent advances in the biology and chemistry of the flavaglines

(2011) Nigel Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

(2011) Jonathan H. Schatz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

(2011) Christina M. Rodrigo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

(2011) Yohann Bernard et al.   PLoS One

A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys

(2011) K. F. Barnhart et al.   Science Translational Medicine

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

(2009) David M. Lucas et al.   BLOOD

Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression

(2009) J Y Zhu et al.   CELL DEATH AND DIFFERENTIATION

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitors of translation initiation as cancer therapeutics

(2009) Lisa Lindqvist et al.   Future Medicinal Chemistry

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Next generation oncology drug development: opportunities and challenges

(2009) Martin E. Gutierrez et al.   Nature Reviews Clinical Oncology

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One