Small-molecule inhibitors of myosin proteins

Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light

(2012) Aliaksandr Mikulich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy

(2012) Mirco Müller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise

(2012) James D. West et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Promising Therapeutic Targets in Neuroblastoma

(2012) K. K. Matthay et al.   CLINICAL CANCER RESEARCH

Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: A novel method suitable for examining dynamic changes in proteins during mitotic progression

(2012) Yuki Matsui et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Kinetic properties and small-molecule inhibition of human myosin-6

(2012) Sarah M. Heissler et al.   FEBS LETTERS

Nonmuscle Myosin II Is Required for Internalization of the Epidermal Growth Factor Receptor and Modulation of Downstream Signaling

(2012) Jong Hyun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes

(2012) P. Taylor Eves et al.   JOURNAL OF CELL BIOLOGY

Structure-based drug discovery of carbonic anhydrase inhibitors

(2012) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Azidoblebbistatin, a photoreactive myosin inhibitor

(2012) M. Kepiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

(2012) Warren R.J.D. Galloway et al.   TRENDS IN MICROBIOLOGY

Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle

(2011) Christopher G. R. Perry et al.   BIOCHEMICAL JOURNAL

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells

(2011) Lara Derycke et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity

(2011) Krishna Chinthalapudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure–Activity Study

(2011) Matthias Preller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Actomyosin mediates gravisensing and early transduction events in reoriented cut snapdragon spikes

(2011) Zhaoqi Zhang et al.   JOURNAL OF PLANT PHYSIOLOGY

Myosin II motor activity in the lateral amygdala is required for fear memory consolidation

(2011) C. F. Gavin et al.   LEARNING & MEMORY

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Cardiomyocyte contractile status is associated with differences in fibronectin and integrin interactions

(2010) Xin Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Myosin V Inhibitor Based on Privileged Chemical Scaffolds

(2010) Kabirul Islam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural and Functional Insights into the Myosin Motor Mechanism

(2010) H. Lee Sweeney et al.   Annual Review of Biophysics

The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea

(2010) Kohsuke Hashimoto et al.   BIOTECHNOLOGY LETTERS

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

(2010) Christopher P. A. T. Lawson et al.   CHEMICAL COMMUNICATIONS

Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease

(2010) Jin Si et al.   LABORATORY INVESTIGATION

Turning enzymes ON with small molecules

(2010) Julie A Zorn et al.   Nature Chemical Biology

Total Synthesis of Pentabromo- and Pentachloropseudilin, and Synthetic Analogues-Allosteric Inhibitors of Myosin ATPase

(2009) René Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genotype-Phenotype Correlation for DFNA22: Characterization of Non-Syndromic, Autosomal Dominant, Progressive Sensorineural Hearing Loss due to MYO6 Mutations

(2009) Vedat Topsakal et al.   AUDIOLOGY AND NEURO-OTOLOGY

Recent advances in computer-aided drug design

(2009) C. M. Song et al.   BRIEFINGS IN BIOINFORMATICS

Myosin VI Undergoes Cargo-Mediated Dimerization

(2009) Cong Yu et al.   CELL

The mechanism of pentabromopseudilin inhibition of myosin motor activity

(2009) Roman Fedorov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression

(2008) Zhyldyz Kabaeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

(2008) N Vickaryous et al.   BRITISH JOURNAL OF CANCER

Structure and Function of Skeletal Muscle in Zebrafish Early Larvae

(2008) Ying Dou et al.   JOURNAL OF GENERAL PHYSIOLOGY

The small molecule tool (S)-(−)-blebbistatin: novel insights of relevance to myosin inhibitor design

(2008) Cristina Lucas-Lopez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach

(2006) I.M. Kapetanovic   CHEMICO-BIOLOGICAL INTERACTIONS