Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients

Early hemorrhage triggers metabolic responses that build up during prolonged shock

(2015) Angelo D'Alessandro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Detailed Description of All Deaths in Both the Shock and Traumatic Brain Injury Hypertonic Saline Trials of the Resuscitation Outcomes Consortium

(2015) Samuel A. Tisherman et al.   ANNALS OF SURGERY

Shock releases bile acidinducing platelet inhibition and fibrinolysis

(2015) Gregory Wiener et al.   JOURNAL OF SURGICAL RESEARCH

Plasma Is the Physiologic Buffer of Tissue Plasminogen Activator-Mediated Fibrinolysis: Rationale for Plasma-First Resuscitation after Life-Threatening Hemorrhage

(2015) Hunter B. Moore et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Pathologic metabolism

(2015) Erik D. Peltz et al.   Journal of Trauma and Acute Care Surgery

Comprehensive Evaluation of Coagulation in Swine Subjected to Isolated Primary Blast Injury

(2015) Nicolas J. Prat et al.   SHOCK

Hemolysis Exacerbates Hyperfibrinolysis, Whereas Platelolysis Shuts Down Fibrinolysis

(2015) Hunter B. Moore et al.   SHOCK

Exploring ethical conflicts in emergency trauma research: The COMBAT (Control of Major Bleeding after Trauma) study experience

(2015) Theresa L. Chin et al.   SURGERY

Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock

(2015) Hunter B. Moore et al.   SURGERY

Pathologic metabolism

(2015) Erik D. Peltz et al.   Journal of Trauma and Acute Care Surgery

The Effectiveness of Different Functional Fibrinogen Polymerization Assays in Eliminating Platelet Contribution to Clot Strength in Thromboelastometry

(2014) Christoph J. Schlimp et al.   ANESTHESIA AND ANALGESIA

Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

(2014) N. Ding et al.   Circulation-Cardiovascular Genetics

Early coagulopathy at hospital admission predicts initial or delayed fibrinogen deficit in severe trauma patients

(2014) Pauline Deras et al.   Journal of Trauma and Acute Care Surgery

Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown

(2014) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats

(2014) Francis J. Castellino et al.   Journal of Trauma and Acute Care Surgery

Elevated Tissue Plasminogen Activator and Reduced Plasminogen Activator Inhibitor Promote Hyperfibrinolysis in Trauma Patients

(2014) Jessica C. Cardenas et al.   SHOCK

Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome

(2014) Angelo D'Alessandro et al.   TRANSFUSION

A time course study of acute traumatic coagulopathy prior to resuscitation: From hypercoagulation to hypocoagulation caused by hypoperfusion?

(2014) Kaipeng Duan et al.   TRANSFUSION AND APHERESIS SCIENCE

Superactivated Platelets

(2013) Marshall Mazepa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

Platelet aggregation following trauma

(2013) Nis A. Windeløv et al.   BLOOD COAGULATION & FIBRINOLYSIS

The role of fibrinogen in trauma-induced coagulopathy

(2013) C. J. Schlimp et al.   Hamostaseologie

Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels

(2013) T. V. COLACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy

(2013) Michael P. Chapman et al.   Journal of Trauma and Acute Care Surgery

A principal component analysis of coagulation after trauma

(2013) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Blood Clots Are Rapidly Assembled Hemodynamic Sensors

(2012) Ryan W. Muthard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Minding the Gaps—and the Junctions, Too

(2012) Lawrence F. Brass et al.   CIRCULATION

Early Platelet Dysfunction: An Unrecognized Role in the Acute Coagulopathy of Trauma

(2012) Max V. Wohlauer et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Hyperfibrinolysis Elicited via Thromboelastography Predicts Mortality in Trauma

(2012) Crystal Ives et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy

(2012) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration

(2012) Bryan A. Cotton et al.   Journal of Trauma and Acute Care Surgery

Hyperfibrinolysis is common in out-of-hospital cardiac arrest

(2012) H. Schöchl et al.   RESUSCITATION

Factor XIII and Tranexamic Acid But Not Recombinant Factor VIIa Attenuate Tissue Plasminogen Activator–Induced Hyperfibrinolysis in Human Whole Blood

(2011) Daniel Dirkmann et al.   ANESTHESIA AND ANALGESIA

Platelet function following trauma

(2011) Cristina Solomon et al.   THROMBOSIS AND HAEMOSTASIS

Coagulation Changes to Systemic Acidosis and Bicarbonate Correction in Swine

(2011) Daniel N. Darlington et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Effect of Hemodilution on Coagulation and Recombinant Factor VIIa Efficacy in Human Blood In Vitro

(2011) Daniel N. Darlington et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

(2010) N. J. MUTCH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis

(2009) Karim Brohi et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE