Extracellular DNA and histones: double-edged swords in immunothrombosis

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

(2015) S. V. R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis

(2015) Safiah H. C. Mai et al.   SHOCK

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells

(2014) F. Semeraro et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

(2014) A. S. Savchenko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

The role of cell-free DNA measured by a fluorescent test in the management of isolated traumatic head injuries

(2014) Gad Shaked et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

(2013) Jean-Marc Tadie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

(2013) K. C. A. A. Wildhagen et al.   BLOOD

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

(2013) Colin Longstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H4 Promotes Prothrombin Autoactivation

(2013) Sergio Barranco-Medina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Human CRP Defends against the Toxicity of Circulating Histones

(2013) S. T. Abrams et al.   JOURNAL OF IMMUNOLOGY

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma DNA is elevated in patients with deep vein thrombosis

(2013) Jose Antonio Diaz et al.   Journal of Vascular Surgery-Venous and Lymphatic Disorders

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanistic View of Risk Factors for Venous Thromboembolism

(2012) Pieter H. Reitsma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

(2012) Maurits L. van Montfoort et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Venous thromboembolism: Epidemiology and magnitude of the problem

(2012) Samuel Z. Goldhaber   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation

(2012) J. H. Morrissey et al.   BLOOD

Measurement of Circulating Cell-Free DNA in Relation to 18F-Fluorocholine PET/CT Imaging in Chemotherapy-Treated Advanced Prostate Cancer

(2012) Sandi Kwee et al.   CTS-Clinical and Translational Science

Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients

(2012) QiXing Chen et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Detection of Extracellular Genomic DNA Scaffold in Human Thrombus: Implications for the Use of Deoxyribonuclease Enzymes in Thrombolysis

(2012) Rahmi Oklu et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Structural Requirements for the Procoagulant Activity of Nucleic Acids

(2012) Julia Gansler et al.   PLoS One

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

(2012) S. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

(2012) Christine Schorn et al.   Frontiers in Immunology

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Temporal trends in patient characteristics and survival of intensive care admissions with sepsis

(2011) Jacob Dreiher et al.   CRITICAL CARE MEDICINE

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Effects of Extracellular DNA on Plasminogen Activation and Fibrinolysis

(2011) Andrey A. Komissarov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Roles for Fibrin, Tissue Factor, Plasminogen Activator Inhibitor-1, and Thrombin Activatable Fibrinolysis Inhibitor, but Not Factor XI, during Defense against the Gram-Negative Bacterium Yersinia enterocolitica

(2011) D. Luo et al.   JOURNAL OF IMMUNOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus

(2011) L. L. SWYSTUN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of Circulating Nucleic Acids in Plasma/Serum

(2009) Asif N. Butt et al.   Annals of the New York Academy of Sciences

Postinjury multiple organ failure

(2009) David Dewar et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Activation of the Human Contact System on Neutrophil Extracellular Traps

(2009) Sonja Oehmcke et al.   Journal of Innate Immunity

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock

(2008) K. Saukkonen et al.   CLINICAL CHEMISTRY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE

NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs)

(2008) Stefan Margraf et al.   SHOCK