Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress

Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice

(2014) Jenna Pekkinen et al.   Nutrition & Metabolism

SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

(2013) Athanassios Vassilopoulos et al.   ANTIOXIDANTS & REDOX SIGNALING

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

(2013) Qiuli Liang et al.   BIOCHEMICAL JOURNAL

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

(2013) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?

(2013) Brenna Osborne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

SIRT5: A Safeguard Against Oxidative Stress-Induced Apoptosis in Cardiomyocytes

(2013) Ban Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus

(2013) Kristen E. Boyle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

(2013) Ondrej Slaby et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle

(2013) Rasmus S. Biensø et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

(2013) Y Cheng et al.   Cell Death & Disease

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases

(2012) Peter W. Stacpoole   AGING CELL

SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB

(2012) Chun-Juan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of mitochondrial FoF1ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA

(2012) Yu-Ting Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

(2012) Jerome Piquereau et al.   CARDIOVASCULAR RESEARCH

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration

(2012) María Morán et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress

(2012) Patrizia D'Aquila et al.   GENE

A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of d-galactose-induced aging rats

(2012) Zhengde Du et al.   HEARING RESEARCH

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoic acid attenuates high-fat-diet–induced oxidative stress and B-cell–related immune depression

(2012) Jue Cui et al.   NUTRITION

Dietary Regulation of Histone Acetylases and Deacetylases for the Prevention of Metabolic Diseases

(2012) Tho Pham et al.   Nutrients

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

(2011) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Isocitrate dehydrogenase mutations in gliomas

(2011) Changcun Guo et al.   CURRENT OPINION IN NEUROLOGY

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation

(2011) Li Xue et al.   FEBS LETTERS

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

(2011) Tetsuro Koyama et al.   FREE RADICAL BIOLOGY AND MEDICINE

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

Mitochondrial SIRT3: A New Potential Therapeutic Target for Metabolic Syndrome

(2011) Jun Yoshino et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Metabolic syndrome: Evidences for a personalized nutrition

(2011) Pablo Perez-Martinez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning

(2011) Sarah J. Borengasser et al.   PLoS One

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Association of the Sirtuin and Mitochondrial Uncoupling Protein Genes with Carotid Plaque

(2011) Chuanhui Dong et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Biochemical Study of Oxidative Stress Markers in the Liver, Kidney and Heart of High Fat Diet Induced Obesity in Rats

(2011) Saad A Noeman et al.   Diabetology & Metabolic Syndrome

CPEO and carnitine deficiency overlapping in MELAS syndrome

(2010) C.-C. Hsu et al.   ACTA NEUROLOGICA SCANDINAVICA

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Mitochondrial SIRT3 and heart disease

(2010) V. B. Pillai et al.   CARDIOVASCULAR RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Long-term High-fat-diet Feeding Impairs Mitochondrial Biogenesis in Liver of Male and Female Rats

(2010) Antònia Nadal-Casellas et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity

(2010) Michael J. Wolfgang et al.   FEBS Journal

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

(2010) Jianjun Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells

(2010) Tong SHI et al.   Journal of Digestive Diseases

Biochemical diagnosis of mitochondrial disorders

(2010) Richard J. T. Rodenburg   JOURNAL OF INHERITED METABOLIC DISEASE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

(2010) Christin Glorioso et al.   NEUROBIOLOGY OF DISEASE

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals

(2010) Sayaka Akieda-Asai et al.   PLoS One

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity

(2009) J. Kent Bigrigg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

(2009) Abdellah Allali-Hassani et al.   BIOCHEMICAL JOURNAL

Activation of PKCδ and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA

(2009) Chun-Yi Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia

(2009) Melanie Gertz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase

(2009) J. R. Ussher et al.   DIABETES

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

(2009) Yongjie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene

(2009) Dina Bellizzi et al.   MOLECULES AND CELLS

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

(2009) S. Someya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function

(2008) Charles S. Lieber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA