Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players

Anisotropic Platinum Nanoparticle-Induced Cytotoxicity, Apoptosis, Inflammatory Response, and Transcriptomic and Molecular Pathways in Human Acute Monocytic Leukemia Cells

(2020) Sangiliyandi Gurunathan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress‐induced RAC autophagy can improve the HUVEC functions by releasing exosomes

(2020) Linxin Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of exosomal microRNAs in lung cancer biology and clinical applications

(2020) Chengping Hu et al.   CELL PROLIFERATION

Platinum nanoparticles induced genotoxicity and apoptotic activity in human normal and cancer hepatic cells via oxidative stress‐mediated Bax/Bcl‐2 and caspase‐3 expression

(2020) Mohammed H. A. Almarzoug et al.   ENVIRONMENTAL TOXICOLOGY

Anticancer Properties of Platinum Nanoparticles and Retinoic Acid: Combination Therapy for the Treatment of Human Neuroblastoma Cancer

(2020) Sangiliyandi Gurunathan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires

(2019) Jiyun Lim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response

(2019) Elisabetta Vulpis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms associated with biogenesis of exosomes in cancer

(2019) Kathleen M. McAndrews et al.   Molecular Cancer

A simple approach for rapid and cost-effective quantification of extracellular vesicles using a fluorescence polarization technique

(2019) Kalishwaralal Kalimuthu et al.   Journal of Biological Engineering

The Effects of Apigenin-Biosynthesized Ultra-Small Platinum Nanoparticles on the Human Monocytic THP-1 Cell Line

(2019) Gurunathan et al.   Cells

Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor Angiogenesis

(2019) Ying Cheng et al.   Journal of Oncology

Tangeretin-Assisted Platinum Nanoparticles Enhance the Apoptotic Properties of Doxorubicin: Combination Therapy for Osteosarcoma Treatment

(2019) Sangiliyandi Gurunathan et al.   Nanomaterials

HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy

(2019) Xiaojuan Zhang et al.   CHEMICAL ENGINEERING JOURNAL

A Comprehensive Review on the Synthesis, Characterization, and Biomedical Application of Platinum Nanoparticles

(2019) Muniyandi Jeyaraj et al.   Nanomaterials

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior

(2018) Shyam K. Bandari et al.   MATRIX BIOLOGY

Exosome isolation from distinct biofluids using precipitation and column-based approaches

(2018) Tânia Soares Martins et al.   PLoS One

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

(2018) Sangiliyandi Gurunathan et al.   MOLECULES

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways

(2018) Sherif E. Emam et al.   Scientific Reports

Serum-reduced media impacts on cell viability and protein expression in human lung epithelial cells

(2018) Mahamud-ur Rashid et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

(2018) Giulia Cesi et al.   Molecular Cancer

Silver nanoparticles suppresses brain-derived neurotrophic factor-induced cell survival in the human neuroblastoma cell line SH-SY5Y

(2017) Jung Hyun Park et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells

(2017) Priya Samuel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

(2017) Mengxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles in lung cancer—From bench to bedside

(2017) Tsukasa Kadota et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer

(2017) Darren J. Wozniak et al.   Nature Communications

Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress

(2017) Mohammed Saeed-Zidane et al.   PLoS One

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells

(2016) Sandra Atienzar-Aroca et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stressors alter intercellular communication and exosome profile of nasopharyngeal carcinoma cells

(2016) Maria Harmati et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Exosomes in tumor microenvironment: novel transporters and biomarkers

(2016) Zhen Wang et al.   Journal of Translational Medicine

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication

(2016) Karol Jelonek et al.   PROTEIN AND PEPTIDE LETTERS

Exosomes in Parkinson’s Disease

(2016) Xiaoqing Wu et al.   Neuroscience Bulletin

Dietary Natural Products for Prevention and Treatment of Liver Cancer

(2016) Yue Zhou et al.   Nutrients

Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy

(2016) Xiao-Qiu Li et al.   Oncotarget

Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF)

(2016) Johnny C. Akers et al.   PLoS One

A novel cisplatin mediated apoptosis pathway is associated with acid sphingomyelinase and FAS proapoptotic protein activation in ovarian cancer

(2015) L. Maurmann et al.   APOPTOSIS

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acetylcholinesterase is associated with a decrease in cell proliferation of hepatocellular carcinoma cells

(2015) Benjamín Pérez-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Systematic review of factors influencing extracellular vesicle yield from cell cultures

(2015) Johann Mar Gudbergsson et al.   CYTOTECHNOLOGY

Increased anti-tumour activity by exosomes derived from doxorubicin-treated tumour cells via heat stress

(2015) Yunshan Yang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells

(2015) Sangiliyandi Gurunathan et al.   International Journal of Nanomedicine

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

(2015) Balu Chopade et al.   International Journal of Nanomedicine

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Green synthesis of platinum nanoparticles that induce cell death and G2/M-phase cell cycle arrest in human cervical cancer cells

(2015) Ali A. Alshatwi et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell

(2015) Xiaolei Ye et al.   Journal of Cancer

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

(2015) Dhruv Kumar et al.   Oncotarget

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Regulation of exosome release by glycosphingolipids and flotillins

(2014) Santosh Phuyal et al.   FEBS Journal

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin

(2014) Xia Xiao et al.   PLoS One

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Are Involved in Mediating Radiation Induced Bystander Signaling in Human Keratinocyte Cells

(2014) K. Kumar Jella et al.   RADIATION RESEARCH

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration

(2014) W. Tris Arscott et al.   Translational Oncology

Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria

(2014) Sangiliyandi Gurunathan et al.   Nanoscale Research Letters

Synthesis of platinum nanoparticles using dried Anacardium occidentale leaf and its catalytic and thermal applications

(2013) D.S. Sheny et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells

(2012) Chin Y. Soo et al.   IMMUNOLOGY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine

(2012) J J Gills et al.   Cell Death & Disease

Microwave-assisted synthesis of platinum nanoparticles and their catalytic degradation of methyl violet in aqueous solution

(2012) Jolly Pal et al.   Applied Nanoscience

The Genomic and Proteomic Content of Cancer Cell-Derived Exosomes

(2012) Meredith C. Henderson et al.   Frontiers in Oncology

N-Acetylcysteine Amide (NACA) Prevents Retinal Degeneration by Up-Regulating Reduced Glutathione Production and Reversing Lipid Peroxidation

(2011) Andrew M. Schimel et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapid biological synthesis of platinum nanoparticles using Ocimum sanctum for water electrolysis applications

(2011) C. Soundarrajan et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

(2011) Margaret Flowers et al.   BREAST CANCER RESEARCH AND TREATMENT

Bio-directed synthesis of platinum nanoparticles using aqueous honey solutions and their catalytic applications

(2011) R. Venu et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

(2011) Malin Hedlund et al.   PLoS One

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

(2011) Katrin J. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

(2010) Nino Tabatadze et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Optical and non-optical methods for detection and characterization of microparticles and exosomes

(2010) E. VAN DER POL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Sphingolipids and expression regulation of genes in cancer

(2010) Gauri A. Patwardhan et al.   PROGRESS IN LIPID RESEARCH

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE