Article
Pharmacology & Pharmacy
Zhenmao Jia, Panxia Wang, Yuansheng Xu, Guodong Feng, Quan Wang, Xiangjun He, Yan Song, Peiqing Liu, Jianwen Chen
Summary: In this study, LH011 was found to have a therapeutic effect on ulcerative colitis (UC). It inhibited the expression of inflammatory cytokines and enhanced the antioxidant capacity. Mechanistically, LH011 exerted its effects by regulating the TLR4/NF-κB and Nrf2/Keap1/HO-1 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Carlotta Bollati, Martina Bartolomei, Jianqiang Li, Anna Arnoldi, Carmen Lammi
Summary: In this study, the anti-inflammatory and immunomodulatory properties of H2 and H3 were molecularly characterized, and it was found that these peptides can reduce inflammatory responses and oxidative stress markers by modulating the NF-kappa B and iNOS pathways, suggesting their potential therapeutic value.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Haihua Zhang, Jing Wang, Wuying Lang, Hongli Liu, Zhiqiang Zhang, Tonglei Wu, Hongqiang Li, Liya Bai, Qiumei Shi
Summary: This study found that albiflorin can inhibit methotrexate-induced enteritis, reduce inflammation, and exert its effects through inhibiting the NF-kappa B/NLRP3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Gong-Rak Lee, Hye In Lee, Narae Kim, Jiae Lee, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Chang-Yeol Yeo, Woojin Jeong
Summary: This study investigated the role of LC8 in nonalcoholic steatohepatitis (NASH) and explored its potential mechanism. The results showed that LC8 can alleviate NASH induced by an MCD diet by inhibiting NF-kappa B and reducing oxidative stress. Therefore, enhancing intracellular LC8 could be a potential therapeutic strategy for NASH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Food Science & Technology
Dan Li, Zhi Li, Caiyi Qiu, Bo Peng, Yan Zhang, Hongwen Sun, Shuo Wang
Summary: This study investigated the hepatotoxicity of 2-amino-3-methylimidazole[4,5-f] quinoline (IQ) in zebrafish models and found that IQ exposure led to significant increases in liver enzymes, oxidative stress, and inflammation levels, while decreasing antioxidant levels. The study also revealed the pathological changes in zebrafish liver tissue induced by IQ exposure and elucidated the underlying molecular mechanisms involved in IQ-induced liver damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Review
Medicine, General & Internal
Lilly M. Wong, Guochun Jiang
Summary: HIV cure is hindered by the presence of quiescent yet replication competent HIV-1, but current research in NF-kappa B signaling pathways shows promise. Both canonical and noncanonical NF-kappa B signaling have been found to promote latency reversal and expression of HIV from reservoirs, offering new avenues for potential functional cure strategies.
Article
Environmental Sciences
Yuming Zhang, Zhen Zhang, Jun Wang, Xiajing Zhang, Jing Zhao, Ning Bai, Annamalai Vijayalakshmi, Qifan Huo
Summary: Scutellarin protects rats from cerebral ischemic injury by inhibiting the inflammatory process through the nuclear factor kappa-B p65 and p38 mitogen-activated protein kinase signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Xinfei Ma, Qinli Ruan, Xiaotian Ji, Ju Yang, Huiping Peng
Summary: The study demonstrated that Ligustrazine had protective effects against hepatotoxicity induced by Cyclophosphamide or its metabolite 4-hydroperoxycyclophosphamide, by improving liver structure and function, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was associated with the inhibition of the Txnip/Trx/NF-kappa B pathway.
Article
Chemistry, Medicinal
Kun Yan, Jianqiang Hu, Tianhua Hou, Xinxin Ci, Liping Peng
Summary: This study demonstrates that Leonurine (Leo) can effectively protect against carrageenan-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappa B pathways through activating the Nrf2 pathway, which may serve as a promising agent for attenuating pleurisy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Nutrition & Dietetics
Yongfeng Zhang, Jie Hao, Zijian Liu, Zhige Li, Lirong Teng, Di Wang
Summary: This study investigated the regulatory effects of Inonotus hispidus (IH) on lipid metabolism in mice fed a high-fat diet (HFD). The results showed that IH could reverse the pathological state of the liver and fat, decrease the levels of LDL-C, TC, TG, and LEP, and increase the level of HDL-C in serum. Additionally, IH improved liver damage and modulated the gut microbiota. IH regulated the Nrf2/NF-κB signaling pathway and oxidative stress. These findings provide experimental evidence for the potential use of IH in obesity treatment.
Article
Orthopedics
Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Summary: This study found that the active ingredient PHI from Forsythiae Fructus can alleviate IL-1 beta-induced inflammation cytokines and ECM degradation by activating Nrf2 and inhibiting the NF-kappa B pathway. This provides a biological rationale for the use of PHI as a potential candidate for OA treatment.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shujuan Li, Yan Li, Li Hou, Li Tang, Fang Gao
Summary: Forsythoside B hampers IL-1 beta-elicited rat chondrocyte apoptosis, oxidative stress, and facilitates proliferation. It suppresses the profiles of inflammatory factors and NOD-like receptor family pyrin domain containing 3 inflammasomes, as well as Kelch-like epichlorohydrin-associated protein-1 (Keap1) and nuclear factor-kappa B (NF-kappa B) phosphorylation, while promotes nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels. Furthermore, Forsythoside B mitigates cartilage damage and degeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)