Article
Chemistry, Medicinal
Xun-Cai Yang, Peng-Li Zhang, Kannekanti Vijaya Kumar, Shuo Li, Rong-Xia Geng, Cheng-He Zhou
Summary: Unique coumarin conjugates with thiazolidinone were utilized as antibacterial modulators to combat multidrug-resistant bacterial infections. The indole-incorporated coumarin thiazolidinone conjugate 14a exhibited broad-spectrum antibacterial activity, low cytotoxicity, and favorable pharmacokinetic properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Krishnaiah Vaarla, Vinod Vishwapathi, Kurt Vermeire, Rajeswar Rao Vedula, Chandrashekhar Kulkarni
Summary: An efficient one-pot synthesis method has been developed for novel compounds with potential antiviral activity, which were screened for activity against a broad spectrum of human viruses. The isolated products were obtained in pure form with high yields through simple workup.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Lu Xu, Jinmeng Yu, Lu Jin, Le Pan
Summary: A series of 4-amino coumarin-based succinate dehydrogenase inhibitors (SDHIs) were designed and synthesized. These compounds showed broad-spectrum antifungal activity against various plant pathogenic fungi in vitro. Among them, compounds 3n and 4e displayed excellent activity against Alternaria alternata and Alternaria solani.
Article
Biochemistry & Molecular Biology
John N. Philoppes, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, Mohamed Sebak, Mostafa A. Darwish, Phoebe F. Lamie
Summary: Three novel series of N-methylsulfonylindole derivatives were synthesized and their different biological activities were studied. These compounds exhibited antimicrobial, antioxidant, and anti-inflammatory activities. Additionally, one of the compounds demonstrated dual COX-2/5-LOX inhibitory activity, and its cardiovascular profile was evaluated using cardiac biomarkers and histopathological study.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Nadia Sadou, Naouel Boufroua, Sophie Poulain-Martini, Elisabet Dunach, Samia Achouche-Bouzroura
Summary: A novel thiazolidinone derivative was synthesized via a three-component reaction, involving thiosemicarbazide, maleimide, and Meldrum's acid. The reaction conditions were optimized, and the best results were obtained with a specific ratio of raw materials and solvent, leading to high product yields and reduced reaction time.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Nisheeth C. C. Desai, Dharmpalsinh J. J. Jadeja, Aratiba M. M. Jethawa, Iqrar Ahmad, Harun Patel, B. P. Dave
Summary: Due to multidrug resistance, microbial infections have become a significant global issue. Scientists have developed new antibiotics to combat these infections caused by resistant bacteria and fungi. In this study, a series of 4-thiazolidinone-based 5-arylidene hybrids were synthesized and evaluated for their antibacterial and antifungal activities. Spectral techniques were used to determine the structure of a newly synthesized hybrid. The compounds showed effective antimicrobial activity against bacterial and fungal strains, and molecular docking and dynamic simulations were conducted to investigate their stability and conformation.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Medicinal
Soha H. Emam, Rasha A. Hassan, Eman O. Osman, Mohammed I. A. Hamed, Amr M. Abdou, Mai M. Kandil, Eman Maher Elbaz, Demiana S. Mikhail
Summary: A series of coumarin derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and inhibited VEGFR-2 with an IC50 value of 0.082 +/- 0.004 mu M. It also caused cell cycle arrest at the G1/S phase. Compound 3b showed the most active antibacterial activity against K. pneumonia, with the same MIC and MBC value of 128 mu g/mL.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Syabilah Sazeli, Amit R. Nath, Mohd Hafiz Ahmad, N. W. M. Zulkifli, Mohd Rafie Johan, Wageeh A. Yehye, Lee Hwei Voon
Summary: In this study, new multipotent antioxidants containing thiosemicarbazides were synthesized and evaluated for their antioxidant activity using DPPH assay, showing great potential in scavenging free radicals. Further investigation revealed that compound 5f' exhibited excellent oxidative stability to TMPTO at high temperature, indicating its promising application in preventing premature oxidative degradation.
Article
Chemistry, Inorganic & Nuclear
Wilian C. Rosa, Inaia O. Rocha, Bruna F. Schmitz, Marcos A. P. Martins, Nilo Zanatta, Isadora Tisoco, Bernardo A. Iglesias, Helio G. Bonacorso
Summary: A series of novel compounds were synthesized through a [3 + 3] cyclocondensation reaction, showing large Stokes shifts and low redox processes. The antioxidant activity evaluation revealed two compounds with significant radical scavenging capacity.
JOURNAL OF FLUORINE CHEMISTRY
(2021)
Article
Chemistry, Physical
Khlood Abou-Melha
Summary: The newly synthesized ligand N-allyl-2-(2,4-dinitrophenyl)hydrazine-1-carbothioamide was found to form H-bonds and complexes with different metal ions, resulting in square planar structure for Cu(II) complex. The ligand and Cd(II) complex exhibited strong antioxidant and antitumor activities.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Organic
Nisheeth C. Desai, Krunalsinh A. Jadeja, Dharmpalsinh J. Jadeja, Vijay M. Khedkar, Prakash C. Jha
Summary: A series of novel compounds were synthesized and evaluated for their antibacterial and antifungal activities, with some showing excellent inhibition potency against bacteria and fungi, as well as high binding affinity to microbial DNA gyrase sub unit B.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Harsha Icharam Narkhede, Avinash Shridhar Dhake, Ajaykumar Rikhabchand Surana
Summary: The novel TSC-DTCs hybrids show promising pharmacological applications with higher activity than their precursor compounds. Some of these hybrids exhibit excellent antioxidant and anticancer properties.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
You Lv, Kun Li, Wei Gao, Zesheng Hao, Weibo Wang, Xiaoyu Liu, Liangfu Tang, Zhijin Fan
Summary: Twenty-one novel strobilurins containing 3,4-dichloroisothiazolocoumarin were designed and synthesized, showing promising fungicidal activities against Sclerotinia sclerotiorum and Botrytis cinerea. These compounds have potential to be further studied as fungicide leads.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Medicinal
Saly Gheda, Eman H. F. Abd El-Zaher, Alaa M. Abou-Zeid, Nesma A. Bedair, Leonel Pereira
Summary: This research evaluated the antifungal effectiveness of Arthrospira platensis extracts against pathogenic fungi and assessed their antioxidant and cytotoxicity effects. The methanol extract showed the highest inhibition zones against Candida albicans. In vivo, the extract cream successfully removed Candida spherical plastopores. The extract also exhibited strong cytotoxic activity against the HepG2 cell line and moderate cytotoxic activity against MCF7 and Hela cells.
Article
Biochemistry & Molecular Biology
Katarzyna Niedzialkowska, Aleksandra Felczak, Iwona E. Glowacka, Dorota G. Piotrowska, Katarzyna Lisowska
Summary: One of the main challenges in medicinal chemistry is the search for new substances with antimicrobial potential. Carbazole-containing compounds have shown promise as antibacterial, antifungal, and antiviral agents. This study examined the antimicrobial potential and toxicity of newly synthesized isomeric fluorinated 4-[4-(benzylamino)butoxy]-9H-carbazole derivatives. The derivatives showed effectiveness in inhibiting the growth of Gram-positive bacteria, particularly Staphylococcus aureus strains. However, Gram-negative strains and human fibroblast cells showed higher resistance and toxicity to these compounds. The results suggest the need for further modification of these structures to enhance their activity against pathogenic microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Construction & Building Technology
Daniela Jaksic, Miranda Sertic, Domagoj Kifer, Sandor Kocsube, Ana Mornar Turk, Biljana Nigovic, Bojan Sarkanj, Rudolf Krska, Michael Sulyok, Maja Segvic Klaric
Summary: Airborne levels of Aspergilli (Versicolores) were three times higher in the flooded village of Gunja compared to the control village, while dustborne isolates were equally distributed in both locations. Dominant Aspergilli species in Gunja included A. jensenii and A. creber, which produced sterigmatocystin and 5-methoxysterigmatocystin, with a higher prevalence in winter. A total of 75 metabolites related to various fungi were detected in dust samples, with majority showing higher prevalence in winter in Gunja.
Article
Food Science & Technology
Maja Kis, Ana Vulic, Nina Kudumija, Bojan Sarkanj, Vesna Jaki Tkalec, Krunoslav Aladic, Mario Skrivanko, Sanja Furmeg, Jelka Pleadin
Summary: By sampling unprocessed cereals from different fields in three regions of Croatia, the study revealed that oats were the most contaminated cereal with T-2/HT-2 toxins, while maize had the lowest contamination level. The concentrations of these mycotoxins in two maize samples exceeded the indicative level recommended by the European Commission, indicating the need for further investigation into the conditions under which these poorly studied toxins are produced.
Article
Biochemistry & Molecular Biology
Nikola Sakac, Dubravka Madunic-Cacic, Dean Markovic, Lucija Hok, Robert Vianello, Bojan Sarkanj, Bojan Durin, Krunoslav Hajdek, Bozo Smoljan, Stjepan Milardovic, Brunislav Matasovic, Marija Jozanovic
Summary: The DHBI-TPB sensor with DHBI-TPB ion-pair demonstrated excellent analytical properties for quantification of anionic surfactants in detergents and household care products. The sensor showed high resistance to various interferences and superior performance for potentiometric titrations of SDS using DMIC as a titrant. Nonionic surfactants negatively impacted the anionic surfactant titration curves and signal change.
Article
Chemistry, Analytical
Mirela Samardzic, Mateja Budetic, Aleksandar Szechenyi, Dean Markovic, Pavo Zivkovic, Bojan Sarkanj, Marija Jozanovic
Summary: A series of nitrogen heterocycles containing long alkyl and polyalkyl chains were synthesized as quaternary ammonium salts in good to excellent yields, and were characterized as potential ionophores for surfactant selective sensors. These newly synthesized compounds showed Nernstian response towards dodecyl sulfate with a limit of detection of 7.5 . 10(-8) M, and were successfully applied for anionic surfactant determination in pure and real systems.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Dominik Braun, Wilfred A. Abia, Bojan Sarkanj, Michael Sulyok, Thomas Waldhoer, Astrid C. Erber, Rudolf Krska, Paul C. Turner, Doris Marko, Chibundu N. Ezekiel, Benedikt Warth
Summary: This study explored the co-exposure of various mycotoxins in mother-infant pairs through innovative LC-MS/MS approaches. While regulated and emerging mycotoxins were frequently detected, particularly ochratoxin A showed moderate associations between milk and urine samples of mothers and infants. Infants were exposed to lower toxin levels compared to their mothers, indicating the protective effect of breastfeeding, though continuous monitoring of chronic low-dose exposure is warranted. Risk management strategies should focus on minimizing early-life exposure to mycotoxin mixtures to safeguard critical developmental stages.
Article
Food Science & Technology
Ante Loncaric, Bojan Sarkanj, Ana-Marija Gotal, Marija Kovac, Ante Nevistic, Goran Fruk, Martina Skendrovic Babojelic, Jurislav Babic, Borislav Milicevic, Tihomir Kovac
Summary: The study examined the resistance of traditional and conventional apple cultivars to Penicillium expansum and found a positive correlation between patulin content and polyphenolic compounds such as catechin, epicatechin, and gallic acid in apples.
Article
Food Science & Technology
Marija Kovac, Mateja Bulaic, Ante Nevistic, Tomislav Rot, Jurislav Babic, Mario Panjicko, Tihomir Kovac, Bojan Sarkanj
Summary: A total of 209 samples of various cereal crops grown in Croatian fields were collected to analyze the occurrence and co-occurrence of EU regulated mycotoxins. The study highlighted Fusarium mycotoxins as the main contaminants, with DON being the most frequent mycotoxin. Maize was found to be the most contaminated cereal type.
Article
Engineering, Chemical
Jelka Pleadin, Tina Lesic, Dragan Milicevic, Ksenija Markov, Bojan Sarkanj, Nada Vahcic, Ivana Kmetic, Manuela Zadravec
Summary: Documented cases of mycotoxin occurrence in meat products indicate the need for further research into potential contamination sources. Contamination can occur through contaminated spices and raw materials, mycotoxin-producing moulds on the surface of cured meats, and contamination from animals fed with contaminated feed. It is essential to determine the concentrations of relevant mycotoxins in order to establish the level of contamination in meat products.
Article
Food Science & Technology
Tina Lesic, Ana Vulic, Nada Vahcic, Bojan Sarkanj, Brigita Hengl, Ivica Kos, Tomaz Polak, Nina Kudumija, Jelka Pleadin
Summary: This study investigated the occurrence of 5 unregulated mycotoxins in traditional dry-cured meat products in five Croatian regions. The results revealed contamination in 27% of samples, with different geographical regions and local weather playing a role in mycotoxin occurrence.
Article
Food Science & Technology
Ana-Marija Gotal Skoko, Ruzica Vilic, Marija Kovac, Ante Nevistic, Bojan Sarkanj, Marta Lores, Maria Celeiro, Martina Skendrovic Babojelic, Tihomir Kovac, Ante Loncaric
Summary: Apples and apple-based products are widely consumed worldwide, but are susceptible to contamination with Penicilium expansum fungi, which produce the harmful mycotoxin patulin. This study found that traditional Croatian apple cultivars exhibited higher resistance to P. expansum infection and higher concentrations of polyphenolic compounds, as well as stronger antioxidant activity.
Article
Chemistry, Analytical
Nikola Sakac, Dubravka Madunic-Cacic, Dean Markovic, Bartolomeo Della Ventura, Raffaele Velotta, Anita Pticek Sirocic, Brunislav Matasovic, Nikolina Sermek, Bojan Durin, Bojan Sarkanj, Marija Jozanovic
Summary: This research presents a low-cost and fast potentiometric surfactant sensor for cationic surfactants using a new ion-pair ionophore. The sensor demonstrated excellent response characteristics and broad linear concentration range to various cationic surfactants. It also showed remarkable stability and can be successfully applied in detection of cationic surfactants in disinfectants and antiseptics.
Article
Plant Sciences
Ana-Marija Gotal Skoko, Bojan Sarkanj, Marta Lores, Maria Celeiro, Martina Skendrovic Babojelic, Dragutin Kamenjak, Ivana Flanjak, Antun Jozinovic, Tihomir Kovac, Ante Loncaric
Summary: Apples and apple-based products are a valuable source of polyphenols in our daily diet. Recent studies have shown that traditional apple varieties contain a higher concentration of polyphenols and antioxidant activity compared to commercial varieties, highlighting their potential as a source of natural antioxidants and polyphenolics.
Article
Chemistry, Analytical
Nikola Sakac, Dubravka Madunic-Cacic, Dean Markovic, Lucija Hok, Robert Vianello, Valerije Vrcek, Bojan Sarkanj, Bojan Durin, Bartolomeo Della Ventura, Raffaele Velotta, Marija Jozanovic
Summary: A novel potentiometric sensor for anionic surfactants based on the DODI-TPB ionophore was developed. The sensor showed good performance in detecting anionic surfactants in real detergent samples, and its synthesis method followed the principles of green chemistry.
Article
Plant Sciences
Katarina Sunic, John Charles D'Auria, Bojan Sarkanj, Valentina Spanic
Summary: Fusarium head blight (FHB) is a dangerous disease of winter wheat, causing reduced yield and quality, as well as mycotoxin production. In this study, the metabolomics of infected and non-infected winter wheat samples from Croatia were analyzed using GC-MS. The results identified ten possible resistance-related metabolites in grains of FHB-resistant wheat varieties. Furthermore, susceptible wheat varieties were found to be closer to glycyl proline, decanoic acid, and lactic acid dimer, which may suppress resistance to FHB.
Article
Biochemistry & Molecular Biology
Iva Pukles, Csilla Pager, Nikola Sakac, Bojan Sarkanj, Brunislav Matasovic, Mirela Samardzic, Mateja Budetic, Dean Markovic, Marija Jozanovic
Summary: This study presents a new strategy for the determination of active compounds in health supplements using contactless conductivity detection on microchip technology. The method allows for the electrophoretic determination of L-carnosine in complex health supplement formulations without pre-concentration and derivatization steps. The method showed excellent reproducibility and accuracy in detecting L-carnosine in different health supplement samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
