Article
Integrative & Complementary Medicine
Kyun Ha Kim, Ji Yeon Lee, Wan Yi Li, Sangwoo Lee, Han-Sol Jeong, Jun-Yong Choi, Myungsoo Joo
Summary: The study demonstrates that the ethanol extract of Garcinia subelliptica Merr. induces autophagy in human lung adenocarcinoma cells. Specifically, autophagy is induced in A549 cells mainly by activating the AMPK pathway, while in SNU2292 cells it is induced primarily by suppressing the mTOR pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Biochemistry & Molecular Biology
YoungSook Yun, Mariko Shioura, Yukio Hitotsuyanagi, Satoshi Yotsumoto, Yuji Takahashi, Yutaka Aoyagi, Takeshi Kinoshita, Koichi Takeya, Hideshi Inoue
Summary: Compounds isolated from Garcinia subelliptica leaves have cytotoxicity and apoptosis-inducing properties, with garcinielliptone G (5) showing the ability to induce apoptosis in human acute monocytic leukemia and T lymphocyte cells. The mechanism of apoptosis involves activation of caspase-3 and caspase-independent pathways.
Article
Genetics & Heredity
Pei-Dong Chen, Da-Juan Chen, Xiu-Rong Ke, Zhi-Xin Zhu, Hua-Feng Wang
Summary: The complete plastome of G. subelliptica has been obtained, showing the typical structure and gene content of angiosperm plastomes. The study revealed the length and gene composition of different regions in the plastome.
MITOCHONDRIAL DNA PART B-RESOURCES
(2022)
Article
Forestry
Ayaka Irei, Matin Miryeganeh, Masanori Tamashiro, Hidetoshi Saze, Naoya Urasaki, Kazuhiko Tarora
Summary: The study estimated the genome size of Garcinia subelliptica and developed a male-specific DNA marker, which could contribute to the more effective conservation of traditional landscapes and future village planning in the northern part of the main island of Okinawa.
JOURNAL OF FOREST RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Ilekuttige Priyan Shanura Fernando, WonWoo Lee, Ginnae Ahn
Summary: Algae, as the oldest representatives of the plant world, have vast reserves and are considered high-quality feedstocks for obtaining various natural products. Phlorotannins and flavonoids, as rich polyphenols in algae, exhibit structural diversity and bioactivity, with potential applications in functional foods, pharmaceuticals, and industrial biotechnology. Further research and applications of these compounds could contribute to health and economic advancement.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
S. Aswathy, I. Hubert Joe, K. B. Rameshkumar
Summary: In this study, a Garcinia imberti isolate called Friedelin was subjected to a detailed theoretical investigation using density functional theory. The study involved calculations of optimized geometry, electronic properties, vibrational spectroscopy, intermolecular interactions, and insilico screening. The results revealed the presence of transannular, flagpole, and stereo electronic hyperconjugative interactions in the compound's optimal geometry, along with non-covalent H...H interactions. The estimated vibrational wavenumbers showed excellent correlation with experimental values. Moreover, the molecule exhibited potential as a treatment option for tuberculosis based on insilico testing against tuberculosis protein 4FDO.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Materials Science, Biomaterials
Md Moniruzzaman, Sayan Deb Dutta, Jin Hexiu, Keya Ganguly, Ki-Taek Lim, Jongsung Kim
Summary: In this study, dual-emissive polyaromatic carbon quantum dots (CQDs) were prepared and demonstrated significant enzyme inhibitory and antioxidative properties, making them potential candidates for bio-imaging probes, antiaging agents, and wound dressing materials.
BIOMATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dong-Bao Hu, Shu-Ya Wei, Jun Yang, Dong-Dong Zhang, Xiao-Yan Duan, Hui Yan, Xing-Zhi Yang, Xue Bai, Ji-Feng Luo, Jing-Hua Yang, Yun-Song Wang, Yue-Hu Wang
Summary: Four undescribed and two known cucurbitane-type triterpenoids, including two heterodimers, were isolated from the branches of Elaeocarpus dubius. These compounds showed cytotoxic activities against various cancer cell lines and antioxidant properties. They also promoted neurite outgrowth in PC12 cells.
Article
Plant Sciences
Shaofang He, Duanyang Weng, Yipeng Zhang, Qiusheng Kong, Keyue Wang, Naliang Jing, Fengfeng Li, Yuebin Ge, Hui Xiong, Lei Wu, De-Yu Xie, Shengqiu Feng, Xiaqing Yu, Xuekui Wang, Shaohua Shu, Zhinan Mei
Summary: This study reports the assembly of a high-quality telomere-to-telomere genome of Chaenomeles speciosa using PacBio HiFi sequencing and Hi-C scaffolding. The genome provides valuable insights into the biosynthesis of medicinal compounds in C. speciosa tissues and contributes to understanding the evolution of the Rosaceae.
HORTICULTURE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Janhavi Prakash, Sindhoora Sallaram, Asha Martin, Ravindra P. Veeranna, Muthukumar Serva Peddha
Summary: Different parts of Garcinia xanthochymus fruit have varying levels of phytochemicals and biological activity, with the peel containing the highest amounts of polyphenols and other beneficial compounds. The peel extract exhibits strong antioxidant and anti-diabetic potential.
Article
Biochemistry & Molecular Biology
Yenni Pintauli Pasaribu, Arif Fadlan, Sri Fatmawati, Taslim Ersam
Summary: This study isolated three polyprenylated benzophenones for the first time from the root bark of Garcinia celebica. These compounds exhibited good antioxidant and cytotoxic activities, especially against various cancer cell lines. One of the compounds also showed activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7. The in silico molecular docking study supported the in vitro activities, and ADMET analysis indicated the potential of these benzophenones as oral drug candidates.
Article
Chemistry, Multidisciplinary
Marcelo D. Catarino, Beatriz S. Baia Costa, Ana Rita Circuncisao, Artur M. S. Silva, Susana M. Cardoso, Susana Santos Braga
Summary: In this study, the interaction between gamma-cyclodextrin (gamma-CD) and phloroglucinol was investigated, resulting in the formation of a solid inclusion compound. The solid-state characterization confirmed the formation of the compound, and the evaluation of its antioxidant potential showed improved activity at the end of the digestion process.
APPLIED SCIENCES-BASEL
(2022)
Article
Acoustics
Zhenjie Tang, Yanrong Wang, Gangliang Huang, Hualiang Huang
Summary: According to the response surface methodology, the optimized conditions for ultrasound-assisted extraction of polysaccharide from Garcinia mangostana L. rinds were determined. Acetylation significantly improved the antioxidant activity of the polysaccharide. Chemical modification is an effective method to improve the properties of polysaccharides, indicating the great research value and potential of Garcinia mangostana L. polysaccharide.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jinhuang Shen, Xinhua Ma, Yubin He, Yanjun Wang, Tianhua Zhong, Yonghong Zhang
Summary: This study found that Melianodiol (MN) can activate the Nrf-2 signaling pathway and inhibit the JAK/STAT, iNOS/eNOS, and NF-kappa B signaling cascades, enhance intestinal barrier function, and effectively reduce the LPS-mediated inflammatory response in mouse macrophages and DSS-induced intestinal injury in UC.
Article
Chemistry, Organic
Shicheng Wang, Dongming Zhang, Jinhua Zhu, Hongdong Liu, Bin Li, Luqi Huang
Summary: Novel compounds were isolated from Achrocline satureioides, with 1 showing potential against Gram-negative bacteria, and both 1 and 2 having significant impact on H1299 cells. Compounds 3-7 exhibited moderate cancer cell lethality and significant anti-inflammatory activities.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Yu-Mei Hsueh, Ying-Chin Lin, Ya-Li Huang, Horng-Sheng Shiue, Yeong-Shiau Pu, Chao-Yuan Huang, Chi-Jung Chung
Summary: The study found an inverse relationship between plasma selenium levels and RCC, while a direct relationship was observed between red blood cell cadmium levels and RCC. Low plasma selenium levels may interact with high total urinary arsenic levels or high red blood cell cadmium concentration to increase the risk of RCC. The multiplicative interaction between low eGFR and high red blood cell cadmium concentration may further increase the risk of RCC.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Oncology
Chung-Hsin Chen, Arthur P. Grollman, Chao-Yuan Huang, Chia-Tung Shun, Viktoriya S. Sidorenko, Keiji Hashimoto, Masaaki Moriya, Robert J. Turesky, Byeong Hwa Yun, Karen Tsai, Stephanie Wu, Po-Ya Chuang, Chao-Hsiun Tang, Wen-Horng Yang, Tzong-Shin Tzai, Yuh-Shyan Tsai, Kathleen G. Dickman, Yeong-Shiau Pu
Summary: This study found that exposure to both aristolochic acids (AA) and arsenic in Taiwan acts additively to increase the risk of developing upper tract urothelial carcinoma (UTUC). The presence of AA exposure showed an additive effect on the UTUC risk along with arsenic exposure.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Biology
Chung-Hsin Chen, Yu-Ching Chen, Yeong-Shiau Pu
Summary: Tumor location determined by mpMRI is significantly associated with local tumor recurrence in patients undergoing PTPC, with only AA tumors increasing the risk of local recurrences.
Article
Medicine, General & Internal
Wei-Lun Huang, Chao-Yuan Huang, Kuo-How Huang, Yeong-Shiau Pu, Hong-Chiang Chang, Po-Ming Chow
Summary: Stratified TURBT demonstrates a higher detrusor muscle sampling rate and better disease outcomes in patients with nonmuscle invasive bladder cancer.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Oncology
Yi-An Liao, Chun-Ju Chiang, Wen-Chung Lee, Bo-Zhi Zhuang, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: This study investigated the association between extranodal extension (ENE) and prognosis in Taiwanese bladder cancer patients with pathological nodal disease treated with radical cystectomy. The presence of ENE significantly reduced overall survival (OS) and cancer-specific survival (CSS) in these patients, with adjuvant chemotherapy showing better survival outcomes.
Article
Oncology
Jhen-Hao Jhan, Wei-Chi Hsu, Yi-Chen Lee, Wei-Ming Li, A-Mei Huang, Hui-Hui Lin, Chien-Sheng Wang, Yi-Ru Wu, Ching-Chia Li, Wen-Jeng Wu, Hung-Lung Ke
Summary: The overexpression of Derlin-1 in UTUC patients is significantly associated with poor prognosis, and in vitro experiments confirm its regulation of invasion and migration in UTUC cells. Additionally, the study reveals that miR-375-3p can suppress cell invasion and migration by directly targeting Derlin-1.
Article
Oncology
Tsu-Ming Chien, Hsiang-Ying Lee, Nirmish Singla, Vitaly Margulis, Yair Lotan, Solomon Lukasz Woldu, Chun-Nung Huang, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Chia-Yang Li, A-Mei Huang, Sheau-Fang Yang, Hung-Pin Tu, Wen-Jeng Wu, Hsin-Chih Yeh
Summary: The study identified multiple factors associated with metachronous contralateral recurrence in patients with UTUC, including a history of bladder cancer, multiple tumors, advanced chronic kidney disease, and elevated serum white blood cell count. It is recommended that patients with these adverse characteristics be closely monitored for the status of the opposite upper urinary tract.
Article
Medicine, Research & Experimental
Yeong-Shiau Pu, Hanjong Ahn, Weiqing Han, Shu-Pin Huang, Hsi-Chin Wu, Lulin Ma, Shunsuke Yamada, Kazutaka Suga, Li-Ping Xie
Summary: This study aimed to evaluate the safety and efficacy of enzalutamide in Asian patients with mCRPC. The results showed that enzalutamide significantly reduced the risk of disease progression and improved secondary efficacy endpoints, with good tolerability.
ADVANCES IN THERAPY
(2022)
Article
Medicine, Research & Experimental
Lee-Moay Lim, Wen-Yu Chung, Daw-Yang Hwang, Chih-Chuan Yu, Hung-Lung Ke, Peir-In Liang, Ting-Wei Lin, Siao Muk Cheng, A-Mei Huang, Hung-Tien Kuo
Summary: This study compares the genetic alterations in urothelial carcinoma (UC) developed after kidney transplantation (UCKT) and in UC in patients on hemodialysis (UCHD). Specific gene mutations were found in UCKT, potentially contributing to the understanding of the molecular pathogenesis of urothelial carcinoma.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yu-Cheng Lu, Chao-Yuan Huang, Chia-Hsien Cheng, Kuo-How Huang, Yu-Chuan Lu, Po-Ming Chow, Yi-Kai Chang, Yeong-Shiau Pu, Chung-Hsin Chen, Shao-Lun Lu, Keng-Hsueh Lan, Fu-Shan Jaw, Pei-Ling Chen, Jian-Hua Hong
Summary: This study compared the clinical outcomes of robotic-assisted laparoscopic radical prostatectomy (RP) and radiotherapy (RT) with long-term androgen deprivation therapy (ADT) in locally advanced prostate cancer (PC). The results showed that RT plus long-term ADT treatment had a clinical benefit in BCR control compared to RP in patients with locally advanced PC.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
R. Kanesvaran, E. Castro, A. Wong, K. Fizazi, M. L. K. Chua, Y. Zhu, H. Malhotra, Y. Miura, J. L. Lee, F. L. T. Chong, Y-S Pu, C-C Yen, M. Saad, H. J. Lee, H. Kitamura, K. Prabhash, Q. Zou, G. Curigliano, E. Poon, S. P. Choo, S. Peters, E. Lim, T. Yoshino, G. Pentheroudakis
Summary: To accommodate the specific requirements of prostate cancer treatment in Asia, a special meeting was convened by ESMO and SSO to revise the guidelines published in 2020. These guidelines represent the consensus opinions of prostate cancer treatment experts from Asian countries and aim to provide optimization and harmonization recommendations for the management of prostate cancer patients across different regions in Asia.
Article
Cell Biology
Chien-Han Yuan, Wei-Chi Hsu, A-Mei Huang, Ben-Chih Yuan, I-Hung Chen, Chia-An Hsu, Rong-Feng Chen, Yih-Min Chu, Hui-Hui Lin, Hung-Lung Ke
Summary: This study elucidated the association between KLF5 and miR-145-5p in NPC cells. miR-145-5p repressed the proliferation, migration, and invasion of NPC cells via inhibition of the KLF5/FAK pathway.
BMC MOLECULAR AND CELL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Shi-Wei Huang, Li-Chin Chen, Chi-Shin Tseng, Chung-Hsin Chen, Lun-Hsiang Yuan, Wen-Yi Shau, Yeong-Shiau Pu
Summary: Novel hormonal agents (NHAs) have improved outcomes in advanced prostate cancer, but their association with cognitive impairment remains unclear. A network meta-analysis found that NHAs, especially enzalutamide, may increase the risk of cognitive impairment compared with placebo/standard care.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Chao-Yuan Huang, Wei-Jen Chen, Hui-Ling Lee, Ying-Chin Lin, Ya-Li Huang, Horng-Sheng Shiue, Yeong-Shiau Pu, Yu-Mei Hsueh
Summary: This study aimed to explore the association between global DNA methylation marker 5-methyl-2-deoxycytidine (5mdC) and renal cell carcinoma (RCC), and investigate the possible modifying effects of plasma folate and vitamin B-12 levels on this association. The study found that higher 5mdC (%) and plasma folate and vitamin B-12 levels were associated with a decreased risk of RCC. Additionally, low plasma folate levels and low 5mdC (%) were associated with a greater odds of RCC compared to controls, as well as low plasma folate levels and high blood cadmium levels.
Review
Urology & Nephrology
Kathleen G. Dickman, Chung-Hsin Chen, Arthur P. Grollman, Yeong-Shiau Pu
Summary: The high incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan is largely due to exposure to aristolochic acid (AA), a principal component of Aristolochia-based herbal medicines. Studies have shown that AA-induced UTUC is associated with higher risks of renal failure and distinctive genetic mutations and DNA adducts. Clinically, AA-related UTUC patients exhibit younger age, female gender, impaired renal function, and a higher recurrence rate of contralateral UTUC.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
