Article
Medicine, Research & Experimental
Yanan Yang, Shijie Cao, Wenyi Xu, Chenchen Zang, Fang Zhang, Yong Xie, Chongming Wu
Summary: Coptidis Rhizoma exhibits anti-hyperlipidemic effects by modulating the composition of intestinal bacteria and fungi, reducing serum lipids and inhibiting hepatic lipid accumulation. There are complex associations between intestinal fungi and bacteria, suggesting a regulatory role of Coptidis Rhizoma in glycolipid metabolism disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yuanfeng Lyu, Lin Lin, Yuning Xie, Dan Li, Min Xiao, Yufeng Zhang, Stanley Chun Kai Cheung, Pang Chui Shaw, Xiao Yang, Paul Kay Sheung Chan, Alice Pik Shan Kong, Zhong Zuo
Summary: Research has shown that different compositions of Coptidis rhizoma extracts (CREs) have varying effects on the degradation of berberine/jatrorrhizine/coptisine/palmatine in rat/mouse intestinal contents and on nine common gastrointestinal bacteria. When orally administered to db/db mice for two weeks, CREA showed the most significant impact on insulin/glucose tolerance test results and blood glucose levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Young Kim, Cheol Park, Min Yeong Kim, Seon Yeong Ji, Hyun Hwangbo, Hyesook Lee, Su Hyun Hong, Min Ho Han, Jin-Woo Jeong, Gi-Young Kim, Chang-Gue Son, JaeHun Cheong, Yung Hyun Choi
Summary: Coptidis Rhizoma has anti-tumor effects on hepatocellular carcinoma by inducing cell apoptosis and autophagy, reducing cell invasion and migration, and suppressing tumor growth. These effects are mediated by the generation of reactive oxygen species (ROS) and suggest a potential pharmacological intervention for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Aeyung Kim, Su-Jin Baek, Sarah Shin, Seo-Young Lee, Sun-Ku Chung
Summary: In cell-based regenerative medicine, induced pluripotent stem cells (iPSCs) generated from adult somatic cells have shown promise as a cell source due to the lack of ethical concerns and immune rejection risk. However, the risk of teratoma formation remains a safety concern. In this study, an ethanol extract of coptidis rhizoma (ECR) is explored for its ability to eliminate undifferentiated iPSCs and prevent teratoma formation. The results demonstrate that ECR induces apoptotic cell death and DNA damage in iPSCs, while leaving differentiated cells unharmed. The active components of ECR, berberine and coptisine, show selective cytotoxicity to iPSCs. This research highlights the potential of ECR in producing safe and effective iPSC-based therapies.
Article
Pharmacology & Pharmacy
Yong-Hwi Kang, Jing-Hua Wang, Jin-Seok Lee, Nam-Hun Lee, Chang-Gue Son
Summary: Colorectal cancer is the second most lethal malignancy worldwide, and its high mortality rate is largely due to cancer metastasis. Suppression of epithelial-to-mesenchymal transition (EMT) has emerged as a promising strategy for treating metastatic cancer. This study evaluated the antimetastatic effect of Coptidis Rhizoma, a traditional Chinese medicine, on drug-resistant colon cancer cells and found that it inhibits EMT through the TGF-beta signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tatiani Uceli Maioli, Esther Borras-Nogues, Licia Torres, Sara Candida Barbosa, Vinicius Dantas Martins, Philippe Langella, Vasco Ariston Azevedo, Jean-Marc Chatel
Summary: Research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. An obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, contributing to chronic inflammation and insulin resistance. Modulating the gut microbiota may be a potential treatment approach for these conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Luying He, Man Chen, Qilian Liang, Yitao Wang, Wen Tan
Summary: Coptidis Rhizoma (C. Rhizoma), a classical Chinese medicinal plant, has been shown to have anticancer effects on gastrointestinal cancer. This review summarizes the chemical components, anticancer mechanisms, and clinical applications of C. Rhizoma, and highlights its potential as an adjuvant candidate against cancers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Wei Zheng, Guixia Sun, Jianhua Chen, Zhihui Li, Ting Zhang, Guijie Wei, Hongya Wang, Xiurui Sun, Zhe Zhang, Wenwen Zhao, Pengkai Ma, Yujie Zhang, Chunyue Zhang
Summary: The study found that Coptidis Rhizoma (CR) decreased the metabolism and absorption of flavonoids in Scutellariae Radix (SR), especially exerting different effects on aglycones and glycosides. This may be one of the potential mechanisms underlying the therapeutic effects of the combination of SR and CR on diabetes mellitus.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Huan He, Jianling Deng, Maochun Yang, Linjing An, Xiaoli Ye, Xuegang Li
Summary: JAT from RC has an effect on treating obesity, and its anti-obesity effect may be exerted via the IRS1/PI3K/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oh-Jun Kwon, Ji-Won Noh, Byung-Cheol Lee
Summary: The study demonstrates that Coptidis Rhizoma has therapeutic effects on obesity-induced inflammation by inhibiting macrophage-mediated inflammation in adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Tianwei Meng, Jiawen Liu, Hong Chang, Rui Qie
Summary: Bioinformatics and network analysis were used to reveal the mechanism of Rhizoma Pinelliae-Rhizoma Coptidis herb pair in the treatment of lung adenocarcinoma. The target and pathway of the herb pair were explored, and potential biomarkers were predicted. A total of 294 therapeutic targets and 47 core targets were obtained.
Article
Biochemistry & Molecular Biology
Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng
Summary: This study analyzed the differences in typical alkaloids of Rhizoma Coptidis at a systematic level, providing comprehensive information on their pharmaceutical mechanisms. Berberine and coptisine showed stronger inhibitory effects on cell proliferation than palmatine, with some similarities in cellular pathways. Additionally, these alkaloids had different regulatory effects on genes involved in lipid metabolism.
Article
Nanoscience & Nanotechnology
Jing Zhao, Qing Zhao, Jing-Ze Lu, Dan Ye, Sheng Mu, Xiao-Di Yang, Wei-Dong Zhang, Bing-Liang Ma
Summary: Proteinaceous nanoparticles isolated from Coptidis Rhizoma extract can form a natural nano-drug delivery system with BBR, thus significantly improving the pharmacokinetics of oral BBR.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yong-Hwi Kang, Jin-Seok Lee, Nam-Hun Lee, Seung-Hyung Kim, Chang-Seob Seo, Chang-Gue Son
Summary: Colorectal cancer (CRC) is the third most common cancer worldwide among both men and women, with early detection and resection being the best treatment and chemotherapy a main treatment option. Coptidis Rhizoma extract (CRE) shows potential as an adjuvant agent against 5-FU-resistant colorectal cancers by reducing cell viability and inhibiting thymidylate synthase (TS) expression.
Article
Biochemistry & Molecular Biology
Aleksandra Maria Kocot, Elzbieta Jarocka-Cyrta, Natalia Drabinska
Summary: This review summarizes the current knowledge on the role of biotics in maintaining the intestinal barrier function. The potential outcomes from in vitro and animal studies are presented, highlighting the need for further well-designed randomized clinical trials. The mechanisms by which biotics regulate intestinal barrier function should be further studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shambhunath Bose, Sunyoung Kim, Yeonsoo Oh, Md. Moniruzzaman, Gyeongjun Lee, Jungsook Cho
Review
Food Science & Technology
Ahtesham Hussain, Shambhunath Bose, Jing-Hua Wang, Mukesh Kumar Yadav, Girish B. Mahajan, Hojun Kim
FOOD RESEARCH INTERNATIONAL
(2016)
Article
Plant Sciences
Md. Moniruzzaman, Shambhunath Bose, Young-Mi Kim, Young-Won Chin, Jungsook Cho
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
AbuZar Ansari, Shambhunath Bose, Mukesh Kumar Yadav, Jing-Hua Wang, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim
Article
Multidisciplinary Sciences
Dong-Woo Lim, Shambhunath Bose, Jing-Hua Wang, Han Seok Choi, Young-Mi Kim, Young-Won Chin, Song-Hee Jeon, Jai-Eun Kim, Hojun Kim
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Na R. Shin, Shambhunath Bose, Jing-Hua Wang, AbuZar Ansari, Soo-Kyoung Lim, Young-won Chin, Han-seok Choi, Hojun Kim
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Genetics & Heredity
Jing-Hua Wang, Shambhunath Bose, Soo-Kyoung Lim, AbuZar Ansari, Young-Won Chin, Han Seok Choi, Hojun Kim
Article
Pharmacology & Pharmacy
AbuZar Ansari, Shambhunath Bose, Jayanta Kumar Patra, Na Rae Shin, Dong-Woo Lim, Koh-Woon Kim, Jing-Hua Wang, Young-Mi Kim, Young-Won Chin, Hojun Kim
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Kyungsun Han, Shambhunath Bose, Jing-Hua Wang, Soo-kyoung Lim, Young-Won Chin, Young-Mi Kim, Han-Seok Choi, Hojun Kim
Article
Endocrinology & Metabolism
Jing-Hua Wang, Shambhunath Bose, Na Rae Shin, Young-Won Chin, Young Hee Choi, Hojun Kim
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Meng Yang, Shambhunath Bose, Soo-Kyoung Lim, Hojun Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nutrition & Dietetics
Yura Choi, Shambhunath Bose, Na Rae Shin, Eun-Ji Song, Young-Do Nam, Hojun Kim
Article
Microbiology
Meng Yang, Shambhunath Bose, Sookyoung Lim, JaeGu Seo, JooHyun Shin, Dokyung Lee, Won-Hyong Chung, Eun-Ji Song, Young-Do Nam, Hojun Kim
Article
Microbiology
Yura Choi, Shambhunath Bose, Jaegu Seo, Joo-Hyun Shin, Dokyung Lee, Yesol Kim, Seung Goo Kang, Hojun Kim
Summary: This study compared the effects of two forms of A. muciniphila on metabolism and immunity, showing that both forms improved obesity and metabolic dysregulation caused by a high-fat diet, while also exhibiting anti-inflammatory properties.
Review
Cell Biology
Shambhunath Bose, Jungsook Cho
AGEING RESEARCH REVIEWS
(2017)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.