Review
Integrative & Complementary Medicine
Lichuang Huang, Qiang Lyu, Wanying Zheng, Qiao Yang, Gang Cao
Summary: Eucommia ulmoides Oliv. as a Traditional Chinese Medicine has been used for treating various diseases since ancient times, and modern pharmacological research has shown its therapeutic effects on conditions such as hypertension, diabetes, Parkinson's disease, and its antioxidant, anti-inflammatory, and anti-cancer activities.
Article
Pharmacology & Pharmacy
Shimaa M. A. Sayed, Karsten Siems, Christian Schmitz-Linneweber, Walter Luyten, Nadine Saul
Summary: This study investigated the effects of Eucommia ulmoides and Cuscuta chinensis extracts on healthspan parameters using the nematode Caenorhabditis elegans. The results showed that E. ulmoides improved physiological fitness, while C. chinensis acted as an overall healthspan enhancer with anti-aging properties and improved physical fitness in the nematodes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Ruo-yan Yang, Kun Liu, Jian-ying Wang, Lei Zhang, Bao-jun Zhang, Ying Yuan
Summary: This study quantified the active constituents of Eucommia ulmoides Oliv. bark and characterized their metabolic profiles. It also evaluated the anti-rheumatoid arthritis effects of certain compounds using in vitro cellular assays. The results provide insights into the pharmacological activity and potential mechanisms of Eucommia ulmoides Oliv.
Article
Chemistry, Multidisciplinary
Xin Dong, Jie Liu, Shu Guo, Fan Yang, Ren Bu, Jingkun Lu, Peifeng Xue
Summary: Eucommia ulmoides is an herb with various pharmacological activities. The bark and leaves of Eucommia ulmoides have different chemical compositions but can both improve bone metabolism and microarchitecture. The study suggests that Eucommia ulmoides leaves can be a potential alternative medical option when Eucommia ulmoides resources are scarce.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Horticulture
Xi Wu, Degang Zhao
Summary: Eucommia ulmoides Oliver, a traditional Chinese medicinal herb, contains a temperature-induced lipocalin gene (EuTIL1) that plays a role in the cold-stress response and enhances cold tolerance in plants. This discovery provides a potential molecular basis for the study of Eucommia ulmoides introduction and serves as a candidate gene for evaluating cold-tolerant plants.
Article
Chemistry, Multidisciplinary
Yingxia Lu, Xuan Dong, Xiaozhen Huang, De-gang Zhao, Yichen Zhao, Lei Peng
Summary: This study explored the molecular mechanism of Eucommia ulmoides counteracting Fusarium oxysporum infection through transcriptomic and proteomic analyses. The response of Eucommia ulmoides to Fusarium oxysporum was found to be potentially related to the unfolded protein response of the endoplasmic reticulum pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rui Han, Tian Yuan, Zhi Yang, Qiang Zhang, Wei-Wei Wang, Li-Bin Lin, Ming-Qiang Zhu, Jin-Ming Gao
Summary: The study isolated 13 anti-neuroinflammatory compounds from Eucommia ulmoides Oliv. leaves, with ulmoidol significantly alleviating neuroinflammatory responses in microglia by inhibiting multiple signaling pathways. These results suggest that ulmoidol may have therapeutic potential for treating neuroinflammation-related neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Mo, Kaiqin Li, Jinhua Zhou, Fumin Zhou, Jiang He, Wansheng Zou, Jian Gao
Summary: Strain Mg02(T) was isolated from the roots of Eucommia ulmoides Oliv. collected from Changde City, Hunan Province, China. The strain showed distinct chemotaxonomic characteristics of the genus Nocardiopsis and phylogenetic analysis suggested that it could be a novel Nocardiopsis species. Therefore, a new species, Nocardiopsis changdeensis sp. nov., is proposed with Mg02(T) as the type strain.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Food Science & Technology
Zhenzhen Ge, Yuanyuan Zhang, Xueyuan Jin, Weijing Wang, Xiaoyuan Wang, Mengpei Liu, Lihua Zhang, Wei Zong
Summary: Dynamic high-pressure microfluidization can increase the alpha-helix to beta-sheet ratio of Eucommia ulmoides seed meal proteins, enhance bioavailability, significantly reduce particle size and zeta potential, improve solubility, enhance water holding capacity and fat absorption capability, and enhance emulsifying capability, showing promising potential for modifying the functional characteristics of the proteins.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Forestry
Shiming Deng, Zhijun Deng, Xiaofeng Wang, Hai Lu, Hua Xue
Summary: This study investigated the seed dormancy of Eucommia ulmoides Oliv., identifying the types of dormancy present and effective treatment methods. The findings contribute to the understanding and utilization of E. ulmoides germplasm resources in breeding and genetic improvement efforts.
Article
Multidisciplinary Sciences
Zhi-Ying Nie, Yu-Hong Li, Lin Li, Xin Zhao
Summary: The study investigated the promoting effect of Eucommia ulmoides Oliv. leaves aqueous extract (AEEL) on a strain of Streptococcus thermophilus with probiotic potential, identifying optimal concentration and cultivation time for promotion. The inhibitory spectrum and antimicrobial activity of the strain with AEEL were assessed, with transcriptome sequencing revealing the mode of action of AEEL and differentially expressed genes related to DNA repair and synthesis functions. This suggests potential applications of E. ulmoides in disease treatment by regulating intestinal flora.
Article
Chemistry, Multidisciplinary
Shuai Feng, Ting Wang, Liming Fan, Xinxin An, Xinli Ding, Minjuan Wang, Xifeng Zhai, Yanjun Cao, Jiao He, Yang Li
Summary: This study investigated the potential mechanism of Eucommia ulmoides-Dipsaci Radix (EU-DR) in treating osteoporosis (OP) using network pharmacology and molecular docking approaches. The results showed that the active compounds in EU-DR had high binding efficiency to target proteins and exerted a therapeutic effect on OP by regulating the osteoclast differentiation related signaling pathway. This study provides a pharmacological basis for treating OP using the EU-DR herbal pair.
Article
Chemistry, Medicinal
Pinger Wang, Jianbo Xu, Qi Sun, Qinwen Ge, Min Qiu, Kaiao Zou, Jun Ying, Wenhua Yuan, Jiali Chen, Qinghe Zeng, Qi Cui, Hongting Jin, Chunchun Zhang, Fanzhu Li
Summary: This study analyzed the active chemical constituents and therapeutic effects of Eucommia ulmoides Oliv. and Glycyrrhiza uralensis Fisch. couplet medicines on knee osteoarthritis (KOA) using UPLC-Q-TOF/MS technique and in vivo experiments. Network pharmacology and molecular docking were employed to predict potential targets for the anti-KOA activities, and PPARG was identified as a therapeutic center. The results suggested that Eucommia ulmoides Oliv. and Glycyrrhiza uralensis Fisch. couplet medicines played a chondroprotective role in treating KOA by inhibiting extracellular matrix degradation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Microbiology
Ping Mo, Yazhi Chen, Fumin Zou, Jinhua Zhou, Wansheng Zou, Jian Gao
Summary: A novel Gram-stain-positive, endophytic actinobacterium, strain HDS5T, was isolated from Eucommia ulmoides Oliv. leaves collected in Changde City, Hunan Province, PR China. The strain has distinctive morphological, physio-biochemical, and genetic characteristics, suggesting that it represents a new Nocardiopsis species named Nocardiopsis eucommiae sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Yan Shao, Song Chen, Ke Zhou, Kaifeng Gan, Jin Li, Chenjie Xia
Summary: In this study, network pharmacology was used to investigate the pharmacological mechanisms of Eucommia ulmoides cortex (EU) against postmenopausal osteoporosis (PMOP). The results showed that EU exerts anti-PMOP effects by modulating multiple biological processes, including cell proliferation, angiogenesis, and inflammatory response. Several pathways, such as the PI3K-AKT pathway and the mitogen-activated protein kinase pathway, may be involved in regulating these biological processes.
Article
Integrative & Complementary Medicine
Qiliang Zhao, Lei Zhang, Shuo Zhang, Xiaoxue Gao, Yuye Li, Minghu Chen, Xiumei Gao, Min Liu
Summary: Traditional Chinese medicine (TCM) treatment for COVID-19 can improve clinical symptoms, and early treatment with TCM can lead to shorter viral shedding. These findings are important for guiding the treatment of COVID-19.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Plant Sciences
Yuying Wang, Xiaoqing Sang, Rui Shao, Honglin Qin, Xuanhao Chen, Zhifeng Xue, Lin Li, Yu Wang, Yan Zhu, Yanxu Chang, Xiumei Gao, Boli Zhang, Han Zhang, Jian Yang
Summary: Xuanfei Baidu Decoction has protective effects against acute inflammation and pulmonary fibrosis by inhibiting the IL-6/STAT3 signaling pathway to protect against macrophage-induced inflammation and pulmonary fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Hui Na Cao, Jing Ya Ruan, Yu Han, Wei Zhao, Ying Zhang, Chang Gao, Hong Hua Wu, Lin Ma, Xiu Mei Gao, Yi Zhang, Tao Wang
Summary: The flavonoid glycosides from A. wilsonii seeds exhibit anti-inflammatory effects by inhibiting the release of nitric oxide through multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Feifei Yang, Boxue Chen, Meiting Jiang, Huimin Wang, Ying Hu, Hongda Wang, Xiaoyan Xu, Xiumei Gao, Wenzhi Yang
Summary: The leaves of Panax species can be used as a source for healthcare products. By using advanced techniques, researchers have successfully identified ginsenoside markers in different varieties of Panax and established characteristic ginsenosides for differentiation.
Article
Biochemical Research Methods
Dongxue Zhao, Meiyu Liu, He Sun, Xiaoyan Xu, Simiao Wang, Hongda Wang, Xue Li, Meiting Jiang, Boxue Chen, Yuying Zhao, Xiumei Gao, Wenzhi Yang
Summary: Addressing chemical complexity is crucial in various research fields. The integration of multidimensional chromatography and mass spectrometry enables comprehensive characterization of herbal metabolites. In this study, a three-dimensional liquid chromatography system combined with quadrupole time-of-flight mass spectrometry was used to fully characterize the metabolome of two Astragalus species. By utilizing an in-house library and reference standards, a total of 513 compounds from the Astragalus species were identified. This approach allows for in-depth characterization of herbal metabolites.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Xiaoyan Qin, Qiu Wei, Ran An, Yun Yang, Mingqi Cai, Xiaoling Han, Haoping Mao, Xiumei Gao
Summary: This study investigates the anti-osteoporotic effects of an ethanol extract of FLL in ovariectomized mice and explores the underlying mechanism. The results show that FLL prevents bone loss and improves bone microstructure by modulating bone and fat balance, suggesting its potential as a therapeutic agent for postmenopausal osteoporosis.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhihao Liu, Xiaozhi Liu, Li Liu, Ying Wang, Jie Zheng, Lan Li, Sheng Li, Han Zhang, Jingyu Ni, Chuanrui Ma, Xiumei Gao, Xiyun Bian, Guanwei Fan
Summary: SUMOylation is a dynamic post-translational modification that maintains cardiac function and protects against hypertrophic response in the heart. The role of SUMO1 in myocardial infarction (MI) and the molecular details of heart cell responses to SUMO1 deficiency were investigated in this study. SUMO1 knockout worsened systolic dysfunction and infarct size after myocardial injury, and its loss promoted proliferation of endothelial cell subsets with angiogenic potential.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Bin Lv, Jinhe Guo, Yaodong Du, Yang Chen, Xin Zhao, Bin Yu, Jiarui Liu, Tianyi Cui, Haoping Mao, Xiaoying Wang, Xiumei Gao
Summary: Respiratory diseases, such as acute lung injury (ALI), have become a global health problem. The excessive activation and recruitment of immunocytes in the lungs, as well as the release of cytokines, are considered the primary causes of ALI. However, the cellular mechanisms involved in ALI remain unknown. Therefore, new therapeutic strategies need to be developed to control inflammation and prevent the worsening of ALI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yang Liu, Rui Shao, Tongchuan Suo, Junjie Zhu, Erwei Liu, Yajing Wang, Lin Miao, Xiumei Gao
Summary: In this study, the effect of DZQE on inflammation-related benign prostatic hyperplasia (BPH) was investigated. The results showed that DZQE can significantly inhibit prostate enlargement and decrease the inflammation index. Furthermore, DZQE was found to suppress inflammation-associated BPH by regulating the ERK1/2 signal through its active components, Tan IIA and Ba.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Xinqin Zhong, Yucui Zhao, Lu Huang, Jiarui Liu, Kaiyue Wang, Xiumei Gao, Xin Zhao, Xiaoying Wang
Summary: In this study, it was demonstrated that L. johnsonii protects cardiac function, delays cardiac pathology, and improves gut barrier integrity by remodeling the gut microbiome. The beneficial effects of L. johnsonii on cardiac function post-AMI were abrogated by microbiome dysbiosis caused by antibiotics. The enrichment of L. johnsonii reshapes the gut microbiome by increasing the abundance of Muribaculaceae, Lactobacillus, and decreasing Romboutsia, Clostridia UCG-014, which are correlated with cardiac traits and serum metabolic biomarkers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan
Summary: Tissue-resident cardiac macrophage subsets play important roles in cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)-expressing macrophages recruit circulating monocytes to infarcted myocardium and promote inflammation. However, small extracellular vesicles (sEV) derived from CCR2 macrophages, which resemble M2-polarized macrophages, have anti-inflammatory effects and contribute to cardiac repair.
Article
Chemistry, Medicinal
Yuxing Huang, Erwei Liu, Xuhua Huang, Jia Hao, Siyuan Hu, Xiumei Gao
Summary: The study investigated the pharmacokinetic properties of Eucommia ulmoides and Psoralea corylifolia in rats. It was found that the combined administration of the two herbs could affect the exposure of the main components of Eucommia ulmoides extract in rats due to altered intestinal absorption. This research provides guidance for the simultaneous clinical administration of Eucommia ulmoides and Psoralea corylifolia.
CHINESE HERBAL MEDICINES
(2023)
Article
Biochemical Research Methods
Xiaoyan Xu, Meiting Jiang, Xiaohang Li, Yu Wang, Meiyu Liu, Hongda Wang, Yueguang Mi, Boxue Chen, Xiumei Gao, Wenzhi Yang
Summary: We propose the concept of a three-dimensional characteristic chromatogram (3D CC) and use it to authenticate various ginseng products through online comprehensive two-dimensional liquid chromatography (LC x LC) technology. By analyzing the stereo peaks and shade depth in the 3D CC, it is feasible to identify and distinguish different ginseng species and Chinese patent medicines. This provides a practical solution for the accurate identification of easily confused traditional Chinese medicines (TCMs).
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Benyu Liu, Shiming Fang, Kun Zhou, Lulu Ma, Yaling Shi, Yuefei Wang, Xiumei Gao
Summary: This study aimed to reveal the hepatotoxicity distinction of coumarin-related compounds from glycosides to aglycones in Fructus Psoraleae (FP) and elucidate their potential mechanism. The results showed that P, IP, FA, and IFA were identified as hepatotoxic compounds, while their glycosides were almost non-hepatotoxic. The conversion from glycosides to aglycones played an essential role in FP-induced hepatotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Xiumei Gao, Chenyan Wang, Yong Ni, Huiling Zhang
Summary: This study aimed to observe the clinical efficacy of acupuncture along fascia, meridians, and nerves combined with ultrasound-guided nerve blockage in the treatment of postherpetic neuralgia. The results showed that the combination treatment was more effective than ultrasound-guided nerve blockage alone.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
