Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Rui Han, Yu-Qi Gao, Ding Li, Xia Yin, Jin-Ming Gao
Summary: Chaga mushroom, known as Inonotus obliquus, has been used as a food and traditional herb in Russia, China, and Japan, showing anti-inflammatory and anticancer activities. Chemical investigations revealed that Inonotusols I and L, two lanostane-type triterpenoids isolated from Chaga, exhibited potent inhibitory effects on nitric oxide (NO) production without significant cytotoxicity. Molecular docking studies confirmed their interaction with inducible nitric oxide synthase (iNOS) protein, indicating their potential anti-inflammatory effects in BV-2 microglial cells. These findings support the potential use of Inonotus obliquus for food and medicinal purposes.
Article
Food Science & Technology
Ye Chang, Ming Bai, Xiao-Bian Xue, Chun-Xin Zou, Xiao-Xiao Huang, Shao-Jiang Song
Summary: This study discovered active compounds from Chaga mushroom and found that compound 1 exhibited remarkable antioxidant and neuroprotective activities, suggesting its potential as a natural ingredient for preventing oxidative stress and nerve damage.
Article
Immunology
Perry Ayn Mayson A. Maza, Ji-Hyun Lee, Yong-Su Kim, Gyu-Min Sun, Youn-Joo Sung, Ludmila P. Ponomarenko, Valentine A. Stonik, Minsook Ryu, Jong-Young Kwak
Summary: The study found that Inotodiol can promote the maturation of dendritic cells (DCs) and induce T cell activation. Additionally, Inotodiol-treated DCs enhance T cell proliferation and IL-2 secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amira Abugomaa, Mohamed Elbadawy, Yusuke Ishihara, Haru Yamamoto, Masahiro Kaneda, Hideyuki Yamawaki, Yuta Shinohara, Tatsuya Usui, Kazuaki Sasaki
Summary: Despite its disadvantages, chemotherapy is commonly used for bladder cancer treatment. Developing natural supplements that target cancer stem cells (CSCs) is necessary. Chaga mushrooms are known for their health-promoting and anti-cancer properties. In this study, the anti-tumor potentials of Chaga mushroom extract against dog bladder cancer organoids (DBCO) were examined.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ibrahim M. Abu-Reidah, Amber L. Critch, Charles F. Manful, Amanda Rajakaruna, Natalia P. Vidal, Thu H. Pham, Mumtaz Cheema, Raymond Thomas
Summary: The study evaluated a modified Swiss water process (SWP) method for extracting bioactive compounds from Chaga mushrooms, finding that the highest total phenolic content and total antioxidant activity were observed at pH 11.5 and 100 degrees C. The extracts contained abundant phenolic compounds and vitamins, with the highest content of vitamin E under acidic pH and high temperature.
Article
Agricultural Engineering
Jindou Shi, Caili Guo, Changyang Lei, Yanyan Liu, Xiaohong Hou, Xin Zheng, Qi Hu
Summary: A high-performance biochar derived from the residue of Chaga mushroom was prepared and characterized in this study. The biochar exhibited a large specific surface area and high adsorption capacity, showing efficient adsorption of pollutants in natural water. The adsorption mechanism included electrostatic attraction, hydrogen bonding, π-π interactions, and pore-filling. Overall, the biochar showed great potential as an effective adsorbent for pollutant removal.
BIORESOURCE TECHNOLOGY
(2022)
Review
Polymer Science
Yangpeng Lu, Yanan Jia, Zihan Xue, Nannan Li, Junyu Liu, Haixia Chen
Summary: Inonotus obliquus, commonly known as Chaga mushroom, is widely used as a medicinal and health food in various countries. Its polysaccharide component, IOPS, is believed to possess significant bioactive properties such as anti-tumor, antioxidant, anti-viral, hypoglycemic, and hypolipidemic activities. Research on the extraction, purification, structural characteristics, and biological activities of IOPS has advanced, with potential applications for the treatment of cancers and type 2 diabetes. New perspectives for future work on IOPS have also been proposed.
Article
Biochemistry & Molecular Biology
Nghia Huynh, Gabriele Beltrame, Marko Tarvainen, Jukka-Pekka Suomela, Baoru Yang
Summary: This study compared the extraction of triterpenoids from Chaga using supercritical CO2 and a modified Folch method. The supercritical CO2 extraction showed lower yield but had advantages such as shorter extraction time and less impact on the environment.
Article
Chemistry, Applied
Xiaomin Li, Wenya Wu, Fengpei Zhang, Xin Hu, Yuan Yuan, Xiaoping Wu, Junsheng Fu
Summary: Water-soluble and water-insoluble melanin were obtained from Inonotus hispidus mushrooms, and their chemical composition and structure were found to differ. Water-soluble melanin consists of smaller, well-arranged particles with high amounts of benzene, phenol, and indole compounds, while water-insoluble melanin consists of larger, irregularly arranged particles with more sugar monomers.
Article
Energy & Fuels
Karina Upska, Linards Klavins, Vitalijs Radenkovs, Vizma Nikolajeva, Leena Faven, Eveliina Isosaari, Maris Lauberts, Lauma Busa, Arturs Viksna, Maris Klavins
Summary: Chaga, a black perennial fungus that grows on birch trunks, has been traditionally used as a health promoting remedy. This study found that supercritical CO2 extraction method could provide comparable yields of bioactive compounds with antimicrobial activity.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biotechnology & Applied Microbiology
Jinghua Hao, Xiaoli Wang, Yanhua Shi, Lingjun Li, Jinxin Chu, Junjie Li, Weiping Lin, Tao Yu, Dianhai Hou
Summary: This study provides a comprehensive analysis of the Inonotus obliquus fungus, including its genome, transcriptome, proteome, and metabolome. The results reveal the potential medicinal and antioxidant properties of the fungus, as well as differential metabolic changes between seed and fermentation culture. The study also establishes a link between transcription levels and expression levels of key genes involved in metabolism.
Review
Plant Sciences
Yanxia Zhao, Weifa Zheng
Summary: The bioactive metabolites from Inonotus obliquus show great potential in inhibiting tumor growth and metastasis through various signaling pathways, while also exhibiting immunomodulatory potential and protecting against gastrointestinal damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lin-song Luo, Yu Wang, Li-jun Dai, Fang-xia He, Jiu-liang Zhang, Qing Zhou
Summary: The study explored the hypouricemic effect of triterpenoid acids from Inonotus obliquus on hyperuricemia mice and deciphered the underlying xanthine oxidase inhibitory mechanism. The triterpenoids were found to efficiently lower uric acid levels and hepatic XO in hyperuricemia mice, indicating potential benefits in controlling hyperuricemia and gout. The findings suggest that Inonotus obliquus could serve as a promising supplement for functional foods or medicines in the treatment of hyperuricemia and gout.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jehane Ibrahim Eid, Majdah Mohammad Al-Tuwaijri, Swabhiman Mohanty, Biswadeep Das
Summary: This study investigated the effects of Chaga mushroom polysaccharides (IOP) on genotoxicity in UVB-exposed zebrafish, finding that IOP treatment significantly reduced DNA damage, enhanced the expression of DNA repair genes, and aided in normal development. The findings suggest the efficacy of IOP in mitigating UV-induced DNA damage.
Review
Mycology
Phoebe Tee Yon Ern, Tang Yin Quan, Fung Shin Yee, Adeline Chia Yoke Yin
Summary: Inonotus obliquus (Chaga) is a medicinal mushroom with therapeutic properties such as anti-inflammatory, antioxidant, anticancer, and anti-diabetic effects. Its health benefits are attributed to various bioactive compounds, and underlying mechanisms have been elucidated in some studies.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jing Zhao, Yang-Hee Jung, Yan Jin, Seulgi Kang, Choon-Gon Jang, Jeongmi Lee
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Yan Jin, Dasom Jung, Ke Li, Keunbae Park, Jaeyoung Ko, Misuk Yang, Jeongmi Lee
APPLIED SCIENCES-BASEL
(2019)
Article
Chemistry, Applied
Eun Mi Kim, Dan Ah Kim, Sung Won Kwon, Yan Jin, Heesoo Lee, Seulgi Kang, Jeongmi Lee
Article
Biochemical Research Methods
Ke Li, Yan Jin, Dasom Jung, Keunbae Park, Hireem Kim, Jeongmi Lee
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Energy & Fuels
Heesoo Lee, Seulgi Kang, Yan Jin, Dasom Jung, Keunbae Park, Ke Li, Jeongmi Lee
Article
Chemistry, Physical
Yan Jin, Dasom Jung, Ke Li, Keunbae Park, Jeongmi Lee
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Physical
Seulgi Kang, Hyun Namgoong, Woo Sung Son, Yong Doo Kim, Kyung Min Jeong, Yan Jin, Hyung-Sik Won, Jongki Hong, Jihoon Jeong, Jeongmi Lee
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Review
Chemistry, Medicinal
Jeongmi Lee, Hireem Kim, Seulgi Kang, Namwook Baik, Inseon Hwang, Doo Soo Chung
ARCHIVES OF PHARMACAL RESEARCH
(2020)
Article
Engineering, Biomedical
Keun-Tae Kim, Ju-Chan Park, Hyeon-Ki Jang, Haeseung Lee, Seokwoo Park, Jumee Kim, Ok-Seon Kwon, Young-Hyun Go, Yan Jin, Wankyu Kim, Jeongmi Lee, Sangsu Bae, Hyuk-Jin Cha
Article
Biochemistry & Molecular Biology
Hireem Kim, Seulgi Kang, Ke Li, Dasom Jung, Keunbae Park, Jeongmi Lee
Summary: In this study, various chitin-glucan complexes (CGCs) were prepared from white button mushroom using deep eutectic solvents (DESs) and compared for their properties. The results showed that CGCs prepared using DESs containing betaine and urea had higher yields, lower protein and mineral contents, lower crystallinity, and more porous surfaces compared to other CGCs. This DES-based method shows potential for preparing advanced biomaterials from mushrooms under mild and ecofriendly conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Ke Li, Jin Hyun Nam, Seulgi Kang, Yuli Liu, Jeongmi Lee
Summary: This study explores the use of carvone mixtures, natural monoterpenoids, as solvents in extraction processes. These mixtures have low viscosity, reasonable biodegradability, and can be substitutes for polar protic and dipolar aprotic solvents. Carvone mixtures were successfully applied to extract valuable pigments from a red algae known as laver.
Article
Chemistry, Physical
Keunbae Park, Bo Young Ham, Ke Li, Seulgi Kang, Dasom Jung, Hireem Kim, Yuli Liu, Inseon Hwang, Jeongmi Lee
Summary: This study systematically investigated the effect of deep eutectic solvents (DESs) on the stability, structure, and activity of proteins using lysozyme as a model. The results showed that DESs can improve the thermal stability and alpha-helical content of lysozyme, indicating a protective effect. The impact of DESs on lysozyme varies with different concentrations, and DESs with polyol as the hydrogen bond donor exhibit better stability and preservation of the native structure compared to those with sugar as the donor.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Green & Sustainable Science & Technology
Yuli Liu, Seulgi Kang, Ke Li, Jingyan Chen, Boyeon Bae, Inseon Hwang, Eun-Young Ahn, Youmie Park, Kwang-Hoon Chun, Jeongmi Lee
Summary: According to the principles of green chemistry, metallic nanoparticles can be synthesized using plant extracts. In this study, deep eutectic solvents (DESs) were used to prepare green tea extracts (GTEs) instead of water, resulting in higher synthesis efficiency and improved properties of silver nanoparticles. Among the DESs, the mixture of glycerol and betaine produced silver nanoparticles with uniform size and crystallinity. Additionally, adding DESs to GTEs enhanced the dispersion of silver nanoparticles.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Analytical
Do Hee Lee, Su Hyeon Hwang, Seoungchul Park, Jeongmi Lee, Han Bin Oh, Sang Beom Han, Kwang-Hyun Liu, Yong-Moon Lee, Hee Soo Pyo, Jongki Hong
Summary: A solvent-free headspace gas chromatography-mass spectrometry (SF-HS-GC/MS) method was developed and validated for screening N-nitrosodimethylamine (NDMA) in various active pharmaceutical ingredients (APIs) and drug products. Experimental parameters such as incubation temperature, incubation time, and sample volume in solvent-free headspace conditions were optimized. The method showed excellent linearity, precision, and accuracy, with no significant matrix effect observed in drug products.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Multidisciplinary
Dasom Jung, Jae Back Jung, Seulgi Kang, Ke Li, Inseon Hwang, Ji Hoon Jeong, Hyung Sik Kim, Jeongmi Lee
Summary: Research showed that ChCl-based DESs exhibited higher cytotoxicity in both in vitro and in vivo tests, particularly compared to their individual constituents. Some DESs were found to induce oxidative stress, ammonia stress, and gut dysbiosis, indicating potential toxic effects beyond simple mixture of components.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
