Potential regenerative treatment strategies for intervertebral disc degeneration in dogs

Coupling of small leucine-rich proteoglycans to hypoxic survival of a progenitor cell-like subpopulation in Rhesus Macaque intervertebral disc

(2013) Shishu Huang et al.   BIOMATERIALS

Long-term culture of bovine nucleus pulposus explants in a native environment

(2013) Bart G.M. van Dijk et al.   Spine Journal

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

(2013) Lucas A Smolders et al.   ARTHRITIS RESEARCH & THERAPY

Structured Coculture of Mesenchymal Stem Cells and Disc Cells Enhances Differentiation and Proliferation

(2012) Aliza A. Allon et al.   CELLS TISSUES ORGANS

Development and Regeneration Potential of the Mammalian Intervertebral Disc

(2012) Helena Barreto Henriksson et al.   CELLS TISSUES ORGANS

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

(2012) Makarand V. Risbud et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Biomechanical assessment of the effects of decompressive surgery in non-chondrodystrophic and chondrodystrophic canine multisegmented lumbar spines

(2012) Lucas A. Smolders et al.   EUROPEAN SPINE JOURNAL

Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

(2012) Rosalyn Delia Abbott et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Tissue engineering approaches to degenerative disc disease – A meta-analysis of controlled animal trials

(2012) A. Mehrkens et al.   OSTEOARTHRITIS AND CARTILAGE

Bi-Directional Exchange of Membrane Components Occurs during Co-Culture of Mesenchymal Stem Cells and Nucleus Pulposus Cells

(2012) Sandra Strassburg et al.   PLoS One

Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients

(2012) Sophie L Niemansburg et al.   Regenerative Medicine

Intervertebral Disc-Derived Stem Cells

(2012) W. Mark Erwin et al.   SPINE

Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds

(2012) Lucas A. Smolders et al.   VETERINARY JOURNAL

Intervertebral disc disease in dogs – Part 1: A new histological grading scheme for classification of intervertebral disc degeneration in dogs

(2012) N. Bergknut et al.   VETERINARY JOURNAL

Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration

(2012) Niklas Bergknut et al.   VETERINARY JOURNAL

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation

(2011) Chitrangada Acharya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation

(2011) Gianluca Vadalà et al.   Journal of Tissue Engineering and Regenerative Medicine

The Dog as an Animal Model for Intervertebral Disc Degeneration?

(2011) Niklas Bergknut et al.   SPINE

Culturing Bovine Nucleus Pulposus Explants by Balancing Medium Osmolarity

(2011) Bart van Dijk et al.   TISSUE ENGINEERING PART C-METHODS

Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study

(2011) Lluis Orozco et al.   TRANSPLANTATION

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

(2011) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

(2011) W Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc

(2011) Matthew R. McCann et al.   Journal of Cell Communication and Signaling

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

(2010) Makarand V. Risbud et al.   DEVELOPMENTAL DYNAMICS

Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model

(2010) Kenji Serigano et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Combined Effects of Limited Nutrition and High-Frequency Loading on Intervertebral Discs With Endplates

(2010) Svenja Illien-Jünger et al.   SPINE

Degenerative Lumbosacral Stenosis in Dogs

(2010) Björn P. Meij et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

(2010) Audrey Gilson et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype

(2010) Casey L Korecki et al.   Stem Cell Research & Therapy

Human Disk Cells from Degenerated Disks and Mesenchymal Stem Cells in Co-Culture Result in Increased Matrix Production

(2009) T. Svanvik et al.   CELLS TISSUES ORGANS

Environmental regulation of notochordal gene expression in nucleus pulposus cells

(2009) Anshu Rastogi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The regenerative capacity of the notochordal cell: tissue constructs generated in vitro under hypoxic conditions

(2009) W. Mark Erwin et al.   JOURNAL OF NEUROSURGERY-SPINE

Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

(2009) Fan Yang et al.   JOURNAL OF PATHOLOGY

Biologic Solutions for Degenerative Disk Disease

(2009) Daniel R. Fassett et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells

(2009) Fan Yang et al.   MOLECULAR THERAPY

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

Coculture of Synovium-Derived Stem Cells and Nucleus Pulposus Cells in Serum-Free Defined Medium With Supplementation of Transforming Growth Factor-β1

(2009) Song Chen et al.   SPINE

Differentiation of Intervertebral Notochordal Cells Through Live Automated Cell Imaging System In Vitro

(2009) Joo Han Kim et al.   SPINE

Intervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells

(2009) Timothy Ganey et al.   SPINE

Effect of Severity of Intervertebral Disc Injury on Mesenchymal Stem Cell-Based Regeneration

(2008) Grace Ho et al.   CONNECTIVE TISSUE RESEARCH

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Biological repair of the degenerated intervertebral disc by the injection of growth factors

(2008) Koichi Masuda   EUROPEAN SPINE JOURNAL

Transplantation of mesenchymal stem cells in a canine disc degeneration model

(2008) Akihiko Hiyama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Noninvasive 3D vital imaging and characterization of notochordal cells of the intervertebral disc by femtosecond near-infrared two-photon laser scanning microscopy and spatial-volume rendering

(2008) Thorsten Guehring et al.   MICROSCOPY RESEARCH AND TECHNIQUE

In Vitro Study on Interaction Between Human Nucleus Pulposus Cells and Mesenchymal Stem Cells Through Paracrine Stimulation

(2008) Shu-Hua Yang et al.   SPINE

Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays

(2008) Ki-Won Kim et al.   Spine Journal

Adipose-Derived Stem Cell Therapy for Intervertebral Disc Regeneration: An In Vitro Reconstructed Tissue in Alginate Capsules

(2008) Paolo Gaetani et al.   TISSUE ENGINEERING PART A

Human mesenchymal stem cell differentiation to NP-like cells in chitosan–glycerophosphate hydrogels

(2007) Stephen M. Richardson et al.   BIOMATERIALS