Article
Nutrition & Dietetics
Lei Wang, Wen Li, Shuzhen Xin, Shuang Wu, Chenglu Peng, Hongyan Ding, Shibing Feng, Chang Zhao, Jinjie Wu, Xichun Wang
Summary: This study investigated the effects of 7S and 11S allergens on the intestine of weaned piglets. The results showed that the piglets in the 7S and 11S groups experienced severe diarrhea and decreased growth rate. The experimental piglets also exhibited more aggressive intestinal inflammation and barrier dysfunction. Additionally, supplementation of 7S and 11S triggered oxidative stress and increased inflammatory response in the intestines of the piglets.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Jenny van Odijk, Adina Weisheit, Monica Arvidsson, Nicolae Miron, Bright Nwaru, Linda Ekerljung
Summary: This study aimed to describe the distribution of DAO in a large representative cohort of adults and determine the association between DAO activity and possible associated factors. The results showed that only a few subjects presented reactions upon histamine intake, while 44% had DAO levels below the suggested normal cut-off values. BMI and age were found to have an impact on DAO activity in women, while only increasing age affected DAO levels in men. No association was found between DAO levels and reported symptoms to histamine-rich foods.
Article
Cell Biology
Ashley Wagner, Syed Benazir Alam, Marianna Kulka
Summary: This study compared the response of different mast cell models to common stimuli and found that factors such as source, age, and biological sex play an important role in phenotypic outcomes and may explain the variability in their function.
CELLULAR IMMUNOLOGY
(2023)
Article
Immunology
Antonio Vega-Rioja, Pedro Chacon, Lourdes Fernandez-Delgado, Bouchra Doukkali, Alberto del Valle Rodriguez, James R. Perkins, Juan A. G. Ranea, Leticia Dominguez-Cereijo, Beatriz Maria Perez-Machuca, Ricardo Palacios, David Rodriguez, Javier Monteseirin, David Ribas-Perez
Summary: This study explores the molecular mechanisms underlying ECP production and investigates the effects of agonists and clinical approaches on its release. The results indicate that IgE-mediated ECP release is dependent on multiple signaling pathways, and ECP release is modulated by certain cytokines and clinical drugs. Additionally, a negative correlation between asthma severity and ECP levels was found.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Li Wei, Dan Ren, Guna Zhao, Lin Zhao
Summary: Corynoline (COR) shows protective effects against ovalbumin (OVA)-induced allergic rhinitis (AR) in mice by reducing histamine intensity, cytokine levels, and NF-kappa B binding activity. The findings suggest that COR could be a potential therapeutic agent for AR.
ARCHIV DER PHARMAZIE
(2021)
Review
Cell Biology
Satoshi Tanaka, Kazuyuki Furuta
Summary: IgE plays a role in protecting mast cells from apoptosis and promoting their maturation, as well as activating immature mast cells to release pro-inflammatory mediators in the absence of antigens. Additionally, IgE indirectly modulates local mast cell maturation and decreased serum IgE concentrations may be associated with therapeutic effects of anti-IgE antibodies in inflammatory diseases.
Review
Biotechnology & Applied Microbiology
Ghalya H. Banafea, Sherin Bakhashab, Huda F. Alshaibi, Peter Natesan Pushparaj, Mahmood Rasool
Summary: Mast cells play a crucial role in inflammatory diseases of the airway tract, releasing various mediators that contribute to immune cell accumulation and tissue remodeling.
Article
Dermatology
Kosuke Kitahata, Kazuhiko Matsuo, Masako Sato, Yoko Susami, Yuta Hara, Toshio Morikawa, Naoki Oiso, Akira Kawada, Atsushi Otsuka, Takashi Nakayama
Summary: Atopic dermatitis is a common inflammatory skin disease characterized by excessive Th2 immune responses. DDH-1, a newly synthesized ascorbic acid derivative, has been shown to suppress pro-inflammatory cytokine expression and reduce Th2 cell infiltration in AD mouse model, suggesting its potential as a therapeutic agent for AD.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Plant Sciences
Biao Wang, Da Teng, Cunhao Yu, Luming Yao, Xiaohong Ma, Tianlong Wu
Summary: By reducing the accumulation of 7S globulin and increasing the content of A2B1a subunit, the sulfur-containing amino acid content in soybean seeds was significantly improved. The secondary structure of 11S globulin was also altered, with an increase in beta-sheet content and a decrease in beta-turn content.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Fisheries
Rui Zhu, Zongyu Liu, Minghui Lu, Xueqin Wu, Xueyuan Zhao, Hong-He Wang, Ya-Nan Quan, Li-Fang Wu
Summary: This study evaluated the mitigative effects of vitamin C (VC) on growth inhibition and intestinal damage induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. Results showed that glycinin significantly decreased fish growth performance, while VC supplementation improved growth and restored normal intestinal morphology and antioxidant capacity.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Immunology
Chiara Tontini, Silvia Bulfone-Paus
Summary: Allergy is a type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms. Novel therapeutic options targeting mast cells activation, such as monoclonal antibodies and allergen-specific immunotherapy, are promising for severe allergies treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jackson P. Sterling, Vincent C. Lombardi
Summary: Major burn trauma triggers inflammatory events that cause significant stress on the body, leading to detrimental responses. However, research suggests that antioxidants may help reduce the risk of complications.
Article
Agriculture, Dairy & Animal Science
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Doaa Salman, Basma H. Marghani, Hossam Elshahat Gadalla, Mohamed Z. Sayed-Ahmed
Summary: The study demonstrated that vitamin C, in combination with tulathromycin, selectively influenced the production of pro-inflammatory cytokines in lambs with pneumonic pasteurellosis, returning the levels of certain cytokines to normal. These findings highlight the potential of vitamin C as an anti-inflammatory drug and ideal immunomodulatory agent in the treatment of respiratory diseases.
Article
Chemistry, Multidisciplinary
Muchun Liu, Pierre-Eric Millard, Henning Urch, Ophelie Zeyons, Douglas Findley, Rupert Konradi, Benedetto Marelli
Summary: There is a growing demand for biodegradable alternatives to non-degradable microplastics in various industries. In this study, the authors demonstrate the microencapsulation of active substances in silk fibroin by adjusting the protein's protonation and chain relaxation. The size of the silk fibroin micelles can be tuned, enabling the manufacturing of microcapsules with various morphologies and structures. The degradation kinetics and sustained release of soluble and insoluble payloads are controlled by modulating the fibroin's beta-sheet content. The microencapsulation of a commonly used herbicide in silk fibroin significantly reduces its burst release, and a greenhouse trial shows reduced crop injury compared to the non-encapsulated version.
Review
Food Science & Technology
Jianmin Wu, Ying Zhao, Xian Wang, Lingchang Kong, Lee J. Johnston, Lin Lu, Xi Ma
Summary: The imbalance of intestinal microecology can lead to impairment of the intestinal mucosa barrier and function, and further damage the functions of distal organs, resulting in systemic diseases.Intestinal microbiota and intestinal mucosa barrier can be shaped and regulated by nutrients and modes of life, which can help mitigate stress.Research shows that dynamic epigenetic modifications of intestinal tissue play a significant role in mediating the interactions between gut microbes and the gut mucosa barrier.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Min Zhou, Lee J. Johnston, Chaodong Wu, Xi Ma
Summary: The incidence of obesity is increasing globally, posing major threats to human health. Accumulated evidence suggests the significance of microorganisms and their metabolites in the development of obesity and related diseases. Microbial-based therapies have shown efficacy in managing various diseases. This review collects key information on obesity-related bacteria, fermentation substrates, and major metabolites, and discusses the molecular mechanisms by which microorganisms cause or inhibit obesity, focusing on microbial metabolites. The advantages and disadvantages of using probiotics, plant extracts, and exercise to control obesity are summarized, and new targets and combined approaches are proposed for future clinical research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Fei Xie, Jiakun Shen, Tianyi Liu, Min Zhou, Lee J. Johnston, Jingwen Zhao, Hongfu Zhang, Xi Ma
Summary: Nutrient sensing is crucial for maintaining body homeostasis and physiological functions. Gut taste receptors play important roles in sensing nutrients and regulating intestinal physiological activities, as well as appetite, body weight, and gut microbiota. Dysfunction of gut taste receptors may lead to digestive and metabolic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Zishen Lin, Xi Ma
Summary: Bile acids are synthesized by the liver and modified by gut microbes to form secondary bile acids with various biological functions. Gut microbes play a significant role in bile acid metabolism and act as cell signals in the gut-liver, gut-brain, and gut-testis axis. The interaction between bile acids and gut microbes not only affects the absorption and metabolism of nutrients, but also regulates immune function.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Peng Tan, Qi Tang, Shenrui Xu, Yucheng Zhang, Huiyang Fu, Xi Ma
Summary: In this study, self-assembling chimeric peptide nanoparticles with excellent stability have been constructed and applied to the treatment of bacterial infections. These nanoparticles show broad-spectrum antibacterial activity, desirable biocompatibility, and resistance to degradation. They can alleviate systemic bacterial infections with negligible toxicity, and their mechanism differs from antibiotics, reducing the risk of drug resistance.
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Nutrition & Dietetics
Yiwei Sun, Ning Ma, Zengkai Qi, Meng Han, Xi Ma
Summary: This study investigated whether coated ZnO (C_ZnO) in low dose could replace the traditional dose of ZnO to improve the growth performance, intestinal function, and gut microbiota structures in weaned piglets. The results showed that a low concentration of C_ZnO could effectively promote growth performance and reduce diarrhea by improving small intestinal morphology and permeability, enhancing barrier function, and regulating gut microbiota structure.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ning Ma, Yiwei Sun, Jiashun Chen, Zengkai Qi, Chunchen Liu, Xi Ma
Summary: This study introduces the enterotype model to decipher the colonization and transition of gut microbiota in Chinese pig breeds. Based on host genetics, three representative enterotype clusters were identified, and Chinese native breeds were found in two of them. The study also isolated Lactobacillus reuteri-E3 as a representative strain, which exhibited strong stress resistance and potential intervention in weaned piglet diseases.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Hu Liu, Dewen Liu, Wenhui Wang, Zhaoning Jiang, Xi Ma, Fenglai Wang
Summary: The purpose of this study is to explore potential plasma metabolism biomarkers reflecting the maintenance status of growing pigs. The results showed that linoleic acid metabolism, tryptophan metabolism, and alanine, aspartate, and glutamate metabolism pathways play a significant regulatory role in the maintenance status of growing pigs.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Nanoscience & Nanotechnology
Shenrui Xu, Peng Tan, Qi Tang, Tao Wang, Yakun Ding, Chenlong Zhou, Yucheng Zhang, Huiyang Fu, Zitian Yue, Xi Ma
Summary: This study developed amphiphilic co-assembled peptide nanofibers with high biological selectivity (PCBP-NCAP NFs) to overcome the high cytotoxicity of peptide PCBP and the low antibacterial activity of peptide NCAP. PCBP-NCAP NFs exhibit broad-spectrum antibacterial activity and excellent biocompatibility, with negligible in vivo and in vitro toxicity. Its unique mechanism of membrane penetration and the ability to bind to anionic components on the surface of pathogenic bacteria make them less susceptible to drug resistance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Zishen Lin, Jianmin Wu, Jinping Wang, Crystal L. Levesque, Xi Ma
Summary: L. reuteri can improve liver health by changing the composition of bile acids and reducing cholestasis-associated microbiota. It can also prevent liver inflammation and hepatocyte apoptosis. Furthermore, ursodeoxycholic acid plays a crucial role in protecting the liver during inflammatory stimulation.
Review
Gastroenterology & Hepatology
Yi-han Wei, Xi Ma, Jiang-Chao Zhao, Xiu-Qi Wang, Chun-Qi Gao
Summary: This review focuses on the role of succinate, a metabolite produced by both host cells and gut microbes, in activating intestinal mucosal cells and regulating the gut-immune tissue axis. It also explores its function as a mediator of microbiota-host crosstalk and its potential in regulating intestinal microbiota homeostasis. The review provides insights into feasible ways to modulate succinate levels and highlights succinate as a potential target for microbial therapeutics for humans.
Article
Biochemistry & Molecular Biology
Yucheng Zhang, Hu Liu, Zitian Yue, Peng Tan, Meige Sun, Linbao Ji, Yueyu Bai, Xi Ma
Summary: The supplementation of Wickerhamomyces anomalus could effectively promote growth performance, alleviate diarrhea, improve antioxidant activity, and modulate the gut microbiota in weaned piglets.
Article
Biochemistry & Molecular Biology
Caiyun Huang, Chenyu Shi, Zhe Li, Wenhui Wang, Dongxu Ming, Youjun Gao, Hu Liu, Xi Ma, Fenglai Wang
Summary: This study found that PQQ supplementation improved growth performance and intestinal morphology, and regulated glycolipid metabolism in weaned pigs, potentially through inhibiting AMPK phosphorylation.
Article
Agriculture, Dairy & Animal Science
Shumin Zhang, Jinbiao Zhao, Jinhua Hu, Hengxun He, Yihan Wei, Linbao Ji, Xi Ma
Summary: The offspring of super-multiparous sows face liver inflammation, which can be improved by GABA supplementation through enhancing antioxidant enzyme activity, reducing the expression of pro-inflammatory cytokines, and regulating the TLR4/NF-κB signaling pathway.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
