Article
Medicine, Research & Experimental
Ayaho Yoshino, Goekhan Goektas, Mehmet K. Mahmut, Yunmeng Zhu, Oender Goektas, Taro Komachi, Kimihiro Okubo, Thomas Hummel
Summary: The study developed a test for assessing retronasal olfaction in healthy individuals and patients with olfactory disorders using tasteless powders. Results showed high correlation between retronasal and orthonasal olfaction, with 16 stimuli effectively differentiating patients from controls.
Article
Medicine, Research & Experimental
Huseyin Ozay, Asli Cakir Cetin, Mustafa Cenk Ecevit
Summary: This study aimed to generate normative data of retronasal olfactory threshold values and validate it by differentiating normosmic and hyposmic cases. Strong correlations between Sniffin' Sticks TDI scores and retronasal odor threshold values were found in both the normosmic and hyposmic groups. ROC analysis showed high sensitivity and specificity for normosmic/hyposmic differentiation using the retronasal olfactory threshold test.
Article
Otorhinolaryngology
Ayaho Yoshino, Robert Pellegrino, Curtis R. Luckett, Thomas Hummel
Summary: This study aimed to establish a test battery for clinical assessment of retronasal odor thresholds and identification, finding significant correlations between retronasal and orthonasal olfaction. The retronasal TI score can effectively differentiate between healthy controls and patients with olfactory dysfunction.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Behavioral Sciences
Thomas Hummel, Dino Podlesek
Summary: This review discusses the importance of assessing olfactory function and provides an overview of commonly used psychophysical tests. It emphasizes the need for objective measurements for patient counseling and tracking changes in olfactory function over time.
Article
Food Science & Technology
Zetian Li, Theresa Gottschall, Antje Haehner
Summary: The present study compares orthonasal and retronasal olfaction in different age groups of healthy individuals. The results show that olfactory function decreases with age, and retronasal olfaction is less affected than orthonasal olfaction. Furthermore, individuals who are unaware of their olfactory loss have better retronasal odor identification. Age is negatively correlated with both orthonasal and retronasal olfaction.
FOOD QUALITY AND PREFERENCE
(2022)
Article
History & Philosophy Of Science
Keith A. Wilson
Summary: The dual role of olfaction in both smelling and tasting has led to the proposition of orthonasal and retronasal olfaction. Recognizing these as complementary concepts rather than competing allows for a powerful framework in addressing questions regarding human multisensory experiences.
Article
Behavioral Sciences
Rui He, Talicia C. Dukes, Leslie M. Kay
Summary: The study found that pre-exposing rats to odorants retronasally with positive or negative reinforcers could lead to a significant difference in learning rate between high- and low-vapor-pressure odorants, but this effect was not observed for novel odorants. This suggests that odorants may generate similar perceptual experiences in a volatility-dependent manner.
Article
Psychology, Multidisciplinary
Pooja R. Pal, Daniel Shepherd, Nazimah Hamid, Michael J. Hautus
Summary: Recent research suggests a significant negative association between odour identification and psychological wellbeing, indicating potential for odour tests as an important assessment tool in clinical settings.
CURRENT PSYCHOLOGY
(2021)
Article
Food Science & Technology
Sarah Beutler, Liliana R. Ladner, Thomas Hummel, Ilona Croy
Summary: The INFOUR short version of the Sniffin' Sticks threshold test saves significant time (42%) while maintaining good validity, making it a potentially valuable tool for study protocols with repeated olfactory threshold measurements. This approach is particularly useful in research protocols that are time intensive or when testing needs to be shortened due to short or subtle interventional effects.
CHEMOSENSORY PERCEPTION
(2022)
Article
Behavioral Sciences
Liam Jennings, Ellie Williams, Marta Avlas, Adam Dewan
Summary: Measures of behavioral sensitivity are important for selecting stimulus concentrations in experiments. This study focused on acetate esters and found that mice are most sensitive to isobutyl acetate and least sensitive to propyl acetate. These updated measures of sensitivity will help guide experimenters in choosing appropriate stimulus concentrations for experiments.
Review
Behavioral Sciences
Michal Pieniak, Anna Oleszkiewicz, Vittoria Avaro, Federico Calegari, Thomas Hummel
Summary: Olfactory training (OT) has been shown to benefit olfactory recovery and is debated for its potential to improve psychological functioning. Research focuses on its utility in clinical practice and the accompanying changes in olfactory loss patients and animal models. Challenges lie in methodological issues in OT research and areas requiring further scientific attention.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Otorhinolaryngology
Michal Pieniak, Anna Oleszkiewicz, Marie Klockow, Ayaho Yoshino, Antje Haehner, Thomas Hummel
Summary: The study found that the q-Powders retronasal identification test showed high sensitivity and moderate specificity in differentiating between subjects with olfactory disorders and those with normal olfaction, making it a useful tool for screening purposes in clinical research.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Behavioral Sciences
Raul Alfaro, Jessica G. Nicanor-Carreon, Tasha Doty, Heather Lugar, Tamara Hershey, Marta Yanina Pepino
Summary: Wolfram syndrome is associated with impairment in smell identification and taste function, but odor-induced taste enhancement is preserved in the presence of reduced olfactory intensity.
Article
Biology
Kyung Soo Kim, Il-Youp Kwak, Hyun Jin Min
Summary: This study aimed to evaluate the PEA-based sniffing bead test as a screening tool for olfactory dysfunction. Significant correlations were found between the PEA bead test and conventional psychophysical olfactory function testing. The PEA bead test showed high sensitivity and specificity for discriminating olfactory dysfunction. These results suggest that the PEA bead test could be a valuable screening tool for olfactory dysfunction.
Article
Food Science & Technology
Matjaz Pirc, Pim Maas, Kees De Graaf, Hye-Seong Lee, Sanne Boesveldt
Summary: This study demonstrates that humans can discriminate food fat content based solely on retronasal olfaction, and this ability is unaffected by habitual intake.
FOOD QUALITY AND PREFERENCE
(2022)
Article
Neuroimaging
S. Negoias, K. Pietsch, T. Hummel
BRAIN IMAGING AND BEHAVIOR
(2017)
Article
Dentistry, Oral Surgery & Medicine
Valerie G. A. Suter, Simona Negoias, Hergen Friedrich, Basile N. Landis, Marco-Domenico Caversaccio, Michael M. Bornstein
CLINICAL ORAL INVESTIGATIONS
(2017)
Article
Psychiatry
Simona Negoias, Ben Chen, Emilia Iannilli, Yuping Ning, Hagen H. Kitzler, Thomas Hummel, Stephanie Krueger
PSYCHIATRY RESEARCH
(2019)
Article
Psychiatry
Laura Danioth, Gladys Brotschi, Ilona Croy, Hergen Friedrich, Marco-Domenico Caversaccio, Simona Negoias
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2020)
Review
Otorhinolaryngology
Stefan Trabut, Hergen Friedrich, Marco Caversaccio, Simona Negoias
AURIS NASUS LARYNX
(2020)
Article
Medicine, Research & Experimental
Simona Negoias, Benjamin Meves, Yunpeng Zang, Antje Haehner, Thomas Hummel
Article
Otorhinolaryngology
Lai-Quan Zou, Thomas Hummel, Martin S. Otte, Thomas Bitter, Gerold Besser, Christian A. Mueller, Antje Welge-Luessen, Olcay Cem Bulut, Oender Goektas, Simona Negoias, Shu-bin Li, Antje Haehner
Summary: The study aimed to investigate the differences in quality of life among patients with olfactory dysfunction of different origin. Results showed that patients with post-infectious and post-traumatic OD had poorer olfactory-related QOL. Olfactory-related QOL was positively associated with olfactory function, disease duration, age, and negatively associated with being female.
Article
Otorhinolaryngology
Cilgia Dur, L. Anschuetz, S. Negoias, O. C. Bulut, A. Angelillo-Scherrer, M. Caversaccio
Summary: This study retrospectively analyzed the efficacy of various treatment options for epistaxis in patients with HHT over 18 years, and concluded that epistaxis in HHT is not curable but can be effectively managed through a comprehensive stepwise approach.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Caroline Huart, Carl M. Philpott, Aytug Altundag, Alexander W. Fjaeldstad, Johannes Frasnelli, Simon Gane, Julien W. Hsieh, Eric H. Holbrook, Iordanis Konstantinidis, Basile N. Landis, Alberto Macchi, Christian A. Mueller, Simona Negoias, Jayant M. Pinto, Sophia C. Poletti, Vijay R. Ramakrishnan, Philippe Rombaux, Jan Vodicka, Antje Welge-Luessen, Katherine L. Whitcroft, Thomas Hummel
Summary: The frequent association between COVID-19 and olfactory dysfunction is leading to a demand for treatment, with systemic corticosteroids considered as an option. However, caution is advised due to weak evidence supporting their effectiveness, high rate of spontaneous recovery, and potential adverse effects. Instead, smell training, which has strong evidence and no known side effects, should be considered initially.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Otorhinolaryngology
Lilia Matosevic, Hergen Friedrich, Simona Negoias, Cilgia Dur, Marco Caversaccio, Patrick Dubach
Summary: This study retrospectively analyzed the symptoms, signs, and radiological and intraoperative descriptions of chorda tympani nerve (CTN) involvement in 73 patients with external auditory canal cholesteatoma (EACC). The results showed that 10 out of 73 patients experienced subjective dysfunction, and 8 had abnormal taste test results. The discussion and conclusion suggest that CTN dysfunction often develops asymptomatically in chronic ears, but up to one out of 10 EACC patients with advanced disease may experience regional gustatory dysfunction prior to surgery.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2023)
Review
Otorhinolaryngology
Montserrat Gallego Compte, Thomas Menter, Nicolas Guertler, Simona Negoias
Summary: Nasal glial heterotopia (NGH) is a rare congenital condition, mainly affecting children, characterized by nasal masses and congestion. Magnetic resonance imaging is necessary for diagnosis and complete surgical resection offers a cure.
ACTA OTORHINOLARYNGOLOGICA ITALICA
(2022)
Letter
Rheumatology
Patricia Baenziger-Sieber, Thomas Daikeler, Simona Negoias, Christoph T. Berger
RHEUMATOLOGY ADVANCES IN PRACTICE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Valerie G. A. Suter, Simona Negoias, Hergen Friedrich, Basile N. Landis, Marco-Domenico Caversaccio, Michael M. Bornstein
Summary: The study found significant differences in taste perception among patients with oral lichen planus, especially in sour taste, when comparing those with tongue lesions to healthy controls. There was a low correlation between subjective and objective taste perception.
ORAL HEALTH & PREVENTIVE DENTISTRY
(2021)
Article
Otorhinolaryngology
Yunpeng Zang, Antje Haehner, Simona Negoias, Theresa Lakner, Thomas Hummel
Summary: The case study involves a 49-year-old female patient who experienced anosmia after a mild head trauma. MRI scans revealed lesions/bleeding in the right frontal lobe and olfactory region. This highlights the importance of conducting MRI scans in cases of apparent mild head trauma with anosmia to detect potential brain damage and raises questions about assessing the severity of head trauma.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2021)
Review
Clinical Neurology
Christian Saleh, Simona Negoias, Franca Wagner, Marie-Luise Mono
CASE REPORTS IN NEUROLOGY
(2018)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
