Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chia-Chu Liu, Chia-Fang Wu, Yung-Chin Lee, Tsung-Yi Huang, Shih-Ting Huang, Hsun-Shuan Wang, Jhen-Hao Jhan, Shu-Pin Huang, Ching-Chia Li, Yung-Shun Juan, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chu-Chih Chen, Ming-Tsang Wu
Summary: Environmental exposure to melamine increases the risk of oxidative stress and early kidney injury. The single-nucleotide polymorphisms (SNPs) of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in patients with calcium urolithiasis.
Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Tong Zhang, Jiaxin Zhang, Ruilan Li
Summary: This study investigated the expression pattern and functional characteristics of p66Shc during preimplantation embryo development in sheep. The results showed that p66Shc was expressed in all stages of sheep early embryos and its expression was regulated during embryonic genome activation. RNAi-mediated knockdown of p66Shc resulted in decreased levels of ROS and DNA damage, and increased levels of antioxidant enzymes. This suggests that p66Shc is involved in the regulation of oxidative stress and DNA damage during sheep early embryonic development.
Article
Fisheries
W. K. M. Omeka, D. S. Liyanage, Taehyug Jeong, Sukkyoung Lee, Jehee Lee
Summary: The study characterized manganese superoxide dismutase in disk abalone (AbMnSOD) through transcriptional analysis, tissue-specific expression studies, activity measurement, and functional validation in transfected cells. The findings indicate that AbMnSOD plays a crucial role in regulating developmental processes and defense mechanisms against oxidative stress in hosts.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyo Seong Ji, Seoung Gun Bang, Min-A Ahn, Gayeon Kim, Eunhui Kim, Seung Hee Eom, Tae Kyung Hyun
Summary: This study found that heat stress can induce the activities of Cu/ZnSODs, FeSODs, and MnSODs in garlic leaves, and the cloned AsSODs encode functional SOD enzymes belonging to the Cu/ZnSOD and MnSOD families. These results provide a solid foundation for an in-depth analysis of the physiological functions of the AsSOD family in garlic plants.
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Daniele Corsi, Niccolo Cavi, Natascia Bruni, Franco Dosio
Summary: Superoxide dismutases (SODs) are metalloenzymes that play a crucial role in antioxidant defense against oxidative stress. While SOD supplementation may help neutralize free-radical excess, clinical evidence for its efficacy is currently lacking.
Article
Biochemistry & Molecular Biology
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtellb, Holly Van Remmen
Summary: This study investigates the effects of elevated oxidative stress induced in the mouse spinal cord through the deletion of Mn-Superoxide dismutase (MnSOD). The results show that the deletion of Sod2 in spinal cord neurons leads to mitochondrial alterations and peroxide generation. This phenotype is characterized by demyelination, inflammation, and progressive paralysis that mimic the symptoms of progressive multiple sclerosis.
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Chemistry, Multidisciplinary
Mario Inclan, Maria Teresa Albelda, Salvador Blasco, Carolina Serena, Javier Ugarte Chicote, Antonio Garcia-Espana, Enrique Garcia-Espana
Summary: Superoxide dismutase (SOD) is important for protecting living organisms from harmful effects, but its therapeutic use is limited. This study found three low-molecular-weight compounds that can form complexes with Mn2+, showing a protective effect in vitro and restoring the growth of SOD-deficient E. coli.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Natascia Bruni, Giorgia Meineri, Daniele Corsi, Niccolo Cavi, Daniela Gastaldi, Franco Dosio
Summary: The review discusses the potential harms of overproduction of free radicals and the importance of SOD supplementation in reducing oxidative stress. It also explores various methods and strategies to improve the bioavailability of SOD in recent years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Shu-Hsuan Hu, Shu-Fan Lin, Ya-Chen Huang, Chien-Hsun Huang, Wen-Yu Kuo, Tsung-Luo Jinn
Summary: AtMTM1 and AtMTM2 in Arabidopsis are functional homologs of yMTM1 in yeast, crucial for activation of MnSOD and maintaining ion homeostasis. They are also involved in Mn and Fe homeostasis, root length, and flowering time. The study suggests an evolutionarily conserved activation mechanism for AtMnSOD in the chloroplast.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Engineering, Biomedical
Tao Gui, Lijun Luo, Bonirath Chhay, Leilei Zhong, Yulong Wei, Lutian Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.
Article
Biochemistry & Molecular Biology
Sukkyoung Lee, Ilson Whang, Qiang Wan, Chulhong Oh, Youngdeuk Lee, Yucheol Kim, Hyowon Kim, Jehee Lee
Article
Biochemistry & Molecular Biology
Don Anushka Sandaruwan Elvitigala, William Shanthakumar Thulasitha, Jehee Lee
Article
Fisheries
William Shanthakumar Thulasitha, Navaneethaiyer Umasuthan, Ilson Whang, Bo-Hye Nam, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
William Shanthakumar Thulasitha, Yucheol Kim, Navaneethaiyer Umasuthan, R. G. P. T. Jayasooriya, Gi-Young Kim, Bo-Hye Nam, Jae Koo Noh, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Navaneethaiyer Umasuthan, M. S. Mothishri, William Shanthakumar Thulasitha, Bo-Hye Nam, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Minyoung Oh, Navaneethaiyer Umasuthan, Don Anushka Sandaruwan Elvitigala, Qiang Wan, Eunyoung Jo, Jiyeon Ko, Gyeong Eon Noh, Sangok Shin, Sum Rho, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
G. I. Godahewa, N. C. N. Perera, S. D. N. K. Bathige, Bo-Hye Nam, Jae Koo Noh, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
N. C. N. Perera, G. I. Godahewa, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Navaneethaiyer Umasuthan, S. D. N. K. Bathige, William Shanthakumar Thulasitha, R. G. P. T. Jayasooriya, Younhee Shin, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Fisheries
R. M. C. Udayangani, S. H. S. Dananjaya, Baldassare Fronte, Cheol-Hee Kim, Jehee Lee, Mahanama De Zoysa
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Fisheries
H. M. L. P. B. Herath, P. D. S. U. Wickramasinghe, S. D. N. K. Bathige, R. G. P. T. Jayasooriya, Gi-Young Kim, Myoung Ae Park, Chul Kim, Jehee Lee
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Chemistry, Multidisciplinary
S. H. S. Dananjaya, R. M. C. Udayangani, Chulhong Oh, Chamilani Nikapitiya, Jehee Lee, Mahanama De Zoysa
Article
Fisheries
William Shanthakumar Thulasitha, Navaneethaiyer Umasuthan, Qiang Wan, Bo-Hye Nam, Tae-Wook Kang, Jehee Lee
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Fisheries
Seongdo Lee, Don Anushka Sandaruwan Elvitigala, Sukkyoung Lee, Hyun Chul Kim, Hae-Chul Park, Jehee Lee
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)
Article
Fisheries
Roopasingam Kugapreethan, Navaneethaiyer Umasuthan, Qiang Wan, William Shanthakumar Thulasitha, Chul Kim, Jehee Lee
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)