TP63 and TP73 in cancer, an unresolved “family” puzzle of complexity, redundancy and hierarchy

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations

(2014) Michela Restelli et al.   HUMAN MOLECULAR GENETICS

TAp73 is essential for germ cell adhesion and maturation in testis

(2014) Lena Holembowski et al.   JOURNAL OF CELL BIOLOGY

TAp73 is required for spermatogenesis and the maintenance of male fertility

(2014) Satoshi Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNp73 Exerts Function in Metastasis Initiation by Disconnecting the Inhibitory Role of EPLIN on IGF1R-AKT/STAT3 Signaling

(2013) Marc Steder et al.   CANCER CELL

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

(2013) Tania Velletri et al.   CELL CYCLE

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation

(2013) Peng Jiang et al.   CELL CYCLE

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

(2013) Z He et al.   CELL DEATH AND DIFFERENTIATION

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Phospho-ΔNp63α regulatesAQP3, ALOX12B, CASP14andCLDN1expression through transcription and microRNA modulation

(2013) Edward A. Ratovitski   FEBS LETTERS

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma

(2013) Matthew R. Ramsey et al.   JOURNAL OF CLINICAL INVESTIGATION

FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis

(2013) Eunmi Park et al.   MOLECULAR CELL

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation

(2013) C Li et al.   Cell Death & Disease

TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

(2012) R Tomasini et al.   CELL DEATH AND DIFFERENTIATION

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

(2012) Xiaohua Su et al.   Cell Metabolism

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

p63 regulates cell proliferation and cell cycle progression-associated genes in stromal cells of giant cell tumor of the bone

(2012) CAROL PO YING LAU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation through p63

(2012) Yong-Sam Jung et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Regulation of ΔNp63α by NFκΒ 

(2011) Tanusree Sen et al.   CELL CYCLE

iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia

(2011) Anissa Chikh et al.   EMBO JOURNAL

IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

(2011) Gaetana Restivo et al.   EMBO JOURNAL

A Symphony of Regulations Centered onp63to Control Development of Ectoderm-Derived Structures

(2011) Luisa Guerrini et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage

(2011) C Lazzari et al.   ONCOGENE

Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

(2011) E. Botti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation

(2010) Antonella Di Costanzo et al.   CELL CYCLE

A feedback regulatory loop between p63 and Dlx3: Implications for epidermal differentiation

(2010) Francesca Moretti et al.   CELL CYCLE

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation

(2010) F. Galli et al.   JOURNAL OF CELL SCIENCE

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice

(2010) Helen A. Thomason et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice

(2010) Alice Nemajerova et al.   JOURNAL OF CLINICAL INVESTIGATION

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

(2010) Francesca Moretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysine Methylation Regulates E2F1-Induced Cell Death

(2010) Haroula Kontaki et al.   MOLECULAR CELL

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway

(2010) I. Dulloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis

(2009) Veronica G. Beaudry et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73

(2009) Toshinori Ozaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes

(2009) K. Lefkimmiatis et al.   CANCER RESEARCH

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

The p53 Family Protein p73 Provides New Insights into Cancer Chemosensitivity and Targeting

(2009) P. Lunghi et al.   CLINICAL CANCER RESEARCH

Amphiregulin Induces the Alternative Splicing of p73 Into Its Oncogenic Isoform ΔEx2p73 in Human Hepatocellular Tumors

(2009) Josefa Castillo et al.   GASTROENTEROLOGY

hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage

(2009) N. Pediconi et al.   MOLECULAR AND CELLULAR BIOLOGY

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

(2009) A Peschiaroli et al.   ONCOGENE

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

(2009) Richard Tomasini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Quest for the 1p36 Tumor Suppressor

(2008) A. Bagchi et al.   CANCER RESEARCH

Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling

(2008) Helen A. Thomason et al.   DEVELOPMENTAL BIOLOGY

IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer

(2008) Pascal Descargues et al.   EMBO JOURNAL

p73 poses a barrier to malignant transformation by limiting anchorage-independent growth

(2008) Michaela Beitzinger et al.   EMBO JOURNAL

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

p53 and p73 in suppression of Myc-driven lymphomagenesis

(2008) Heidi Griesmann et al.   INTERNATIONAL JOURNAL OF CANCER

IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal Dysplasias

(2008) Barbara Marinari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

(2008) M. Sauer et al.   NUCLEIC ACIDS RESEARCH

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

(2008) S. Patel et al.   NUCLEIC ACIDS RESEARCH

TAp73β and DNp73β activate the expression of the pro-survival caspase-2 S

(2008) Wen Hong Toh et al.   NUCLEIC ACIDS RESEARCH

ΔNp63 Is Essential for Epidermal Commitment of Embryonic Stem Cells

(2008) Alain Medawar et al.   PLoS One

The tumor suppressor activity of IKK  in stratified epithelia is exerted in part via the TGF-  antiproliferative pathway

(2008) B. Marinari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IKK  is a critical coregulator of a Smad4-independent TGF -Smad2/3 signaling pathway that controls keratinocyte differentiation

(2008) P. Descargues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to p53, p63, and p73

(2008) Ross Alexander Robinson et al.   STRUCTURE

Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1

(2007) Shourong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS