TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells

Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy

(2014) Wei Gao et al.   HEPATOLOGY

Ubiquitin E3 ligase SCFβ-TRCP regulates TRIB2 stability in liver cancer cells

(2013) Yongxia Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NKX2-1/TTF-1: An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression

(2013) Tomoya Yamaguchi et al.   CANCER CELL

Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver Cancer

(2013) Jiayi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/ -Catenin Signaling

(2013) C. Fei et al.   MOLECULAR AND CELLULAR BIOLOGY

TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function

(2013) Jiayi Wang et al.   MOLECULAR CELL

Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL

(2012) Maura M. Hannon et al.   BRITISH JOURNAL OF HAEMATOLOGY

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

(2011) K B Grandinetti et al.   ONCOGENE

Differential ability of Tribbles family members to promote degradation of C/EBP  and induce acute myelogenous leukemia

(2010) P. H. Dedhia et al.   BLOOD

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

(2010) K. Keeshan et al.   BLOOD

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

(2010) F Zanella et al.   ONCOGENE

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

(2008) A Bengochea et al.   BRITISH JOURNAL OF CANCER