Article
Multidisciplinary Sciences
Emilie Ronin, Charlotte Pouchy, Maryam Khosravi, Morgane Hilaire, Sylvie Gregoire, Armanda Casrouge, Sahar Kassem, David Sleurs, Gaelle H. Martin, Noemie Chanson, Yannis Lombardi, Guilhem Lalle, Harald Wajant, Cedric Auffray, Bruno Lucas, Gilles Marodon, Yenkel Grinberg-Bleyer, Benoit L. Salomon
Summary: The study reveals that TNFR2-expressing Treg cells play a crucial role in suppressing autoimmune diseases in the central nervous system during peak disease, maintaining their functionality and sustained expression of suppressive genes. This late effect also provides insights into the treatment outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Huaiping Zhu, Zhaoyu Liu, Junqing An, Miao Zhang, Yu Qiu, Ming-Hui Zou
Summary: AMPK plays a crucial role in maintaining the immunosuppressive function of Treg cells and confers protection against autoimmune liver disease.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fengqian Chen, Qi Liu
Summary: Phytoconstituents have been found to play critical roles in immune regulations and have potential as anti-inflammatory agents. However, traditional phyto-derived medicines have limitations in clinical administration, while phyto-derived nano-approaches may provide solutions. Therefore, the development of phytoconstituents' nano-delivery designs and new therapeutical applications is of great importance.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Yahya Asemani, Sajad Najafi, Fatemeh Ezzatifar, Naime Majidi Zolbanin, Reza Jafari
Summary: Extracellular vesicles (EVs) secreted by T regulatory (Treg) cells regulate immune responses by producing a cell-free tolerogenic environment. These EVs function through processes such as miRNA-induced gene shutdown and upmodulation, surface protein activity, and enzyme transfer. The cohesive structure of exosomes allows them to cross the blood-brain barrier and deliver their cargo to target cells with specific receptors. These findings have important implications for the treatment of inflammation, autoimmune diseases, and tissue transplantation survival.
CELL AND BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Microbiology
Eric M. Brown, Jon Clardy, Ramnik J. Xavier
Summary: Metabolites from commensal gut microbes have significant impacts on host health through immune recognition and modulation of various metabolic pathways. The gut microbiota plays a dual role in transforming and synthesizing lipids, as well as breaking down dietary lipids to generate secondary metabolites with host regulatory properties. Recent research has highlighted the signaling activities of lipids, which have potential effects on host health and physiology. This review focuses on the functions of bioactive lipids in mammalian physiology, with a particular emphasis on immunity and metabolism.
CELL HOST & MICROBE
(2023)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Qi Kang, Luyao Li, Yucheng Pang, Wenhua Zhu, Liesu Meng
Summary: Ym1 is a rodent-specific chitinase-like protein that lacks catalytic activity and is mainly produced by macrophages and neutrophils. It plays a significant role in alternative activation of macrophages in mice and is commonly used as a marker for macrophage phenotype distinction. Ym1 has been found to have multifaceted and sometimes contradictory regulatory effects, and is associated with various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yibo Chen, Mengmeng Jiang, Xin Chen
Summary: TNFR2 agonists have potential as therapies for inflammatory diseases by activating and expanding immunosuppressive Treg cells and MDSCs. However, the role of TNFR2 signaling in immune or inflammatory responses is complex due to its expression on both Treg cells and activated effector T cells. This review analyzes factors that may influence the therapeutic outcomes of TNFR2 agonism and discusses the future direction of developing TNFR2 agonists as therapeutic agents based on recent progress in TNFR2 biology and agonistic agents.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Liam J. O'Neil, Christopher B. Oliveira, Xinghao Wang, Mario Navarrete, Ana Barrera-Vargas, Javier Merayo-Chalico, Rwan Aljahdali, Eduardo Aguirre-Aguilar, Philip Carlucci, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis (RA). This study found that carbamylation, a posttranslational modification, is linked to increased bone erosion in RA. The researchers demonstrated that neutrophil extracellular traps (NETs) and their carbamylated protein cargo directly promote bone destruction by inducing osteoclast formation.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Rebecca L. Ross, Clarissa Corinaldesi, Gemma Migneco, Ian M. Carr, Agne Antanaviciute, Christopher W. Wasson, Antonio Carriero, Jorg H. W. Distler, Steve Holmes, Yasser M. El-Sherbiny, Clive S. McKimmie, Francesco Del Galdo
Summary: Human pDC play a significant role in inflammation and immune-driven skin fibrosis, which can be effectively blocked by BDCA2-targeting, providing direct evidence supporting the development of attenuation of pDC function as a therapeutic application for SSc.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Xinzhe Feng, Chen Wang, Boyao Ji, Junjie Qiao, Yihong Xu, Shanbang Zhu, Zhou Ji, Bole Zhou, Wenwen Tong, Weidong Xu
Summary: This study used single-cell RNA sequencing to reveal the dynamics of cell subpopulations, gene expression, and intercellular interactions during the pathogenesis of ankylosing spondylitis, providing new insights into the cellular and molecular mechanisms of osteogenesis and potential therapeutic strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Kastriot Kastrati, Daniel Aletaha, Gerd R. Burmester, Eva Chwala, Christian Dejaco, Maxime Dougados, Iain B. McInnes, Angelo Ravelli, Naveed Sattar, Tanja A. Stamm, Tsutomu Takeuchi, Michael Trauner, Desiree van der Heijde, Marieke J. H. Voshaar, Kevin Winthrop, Josef S. Smolen, Andreas Kerschbaumer
Summary: IL-6 inhibition shows positive efficacy in treating various inflammatory diseases with a safety profile comparable to other bDMARDs.
Article
Cardiac & Cardiovascular Systems
Fernando Alfonso, Jose M. de la Torre Hernandez, Borja Ibanez, Manel Sabate, Manuel Pan, Rajiv Gulati, Jacqueline Saw, Dominick J. Angiolillo, David Adlam, Francisco Sanchez-Madrid
Summary: BA-SCAD is a clinical trial aimed at evaluating the efficacy of pharmacological therapy in patients with SCAD. Patients will be randomly assigned to different treatment methods, and the results will be evaluated based on primary efficacy and safety endpoints. In addition, a comprehensive set of additional substudies will be conducted to gain a holistic understanding of this unique disease.
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Immunology
Marta Calvet-Mirabent, Daniel T. Claiborne, Maud Deruaz, Serah Tanno, Carla Serra, Cristina Delgado-Arevalo, Ildefonso Sanchez-Cerrillo, Ignacio de Los Santos, Jesus Sanz, Lucio Garcia-Fraile, Francisco Sanchez-Madrid, Arantzazu Alfranca, Maria Angeles Munoz-Fernandez, Todd M. Allen, Maria J. Buzon, Alejandro Balazs, Vladimir Vrbanac, Enrique Martin-Gayo
Summary: The combination of 2‘3’-c ' diAM(PS)2 and Poly I:C as adjuvants can enhance DCs' ability to induce polyfunctional HIV-1 specific CD8(+) T-cell responses, reducing the severity of CD4(+) T-cell depletion following HIV-1 infection, and preserving the specific polyfunctional responses of CD8(+) T cells. The priming of DCs with PolyI:C and STING agonists may be useful for future HIV-1 vaccine studies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Laura Esparcia-Pinedo, Pedro Martinez-Fleta, Noelia Ropero, Paula Vera-Tome, Hugh T. Reyburn, Jose M. Casasnovas, Jose M. Rodriguez Frade, Mar Vales-Gomez, Carlos Vilches, Enrique Martin-Gayo, Cecilia Munoz-Calleja, Francisco Sanchez-Madrid, Arantzazu Alfranca
Summary: The immune response to the SARS-CoV-2 vaccination is important for developing new vaccines and optimizing prevention strategies. Analysis of the adaptive immunity in healthy donors and convalescent individuals before and after vaccination revealed specific changes in CD4+ T cell reactivity and antibody levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pedro Martinez-Fleta, Paula Vera-Tome, Maria Jimenez-Fernandez, Silvia Requena, Emilia Roy-Vallejo, Ancor Sanz-Garcia, Marta Lozano-Prieto, Celia Lopez-Sanz, Alicia Vara, Angel Lancho-Sanchez, Enrique Martin-Gayo, Cecilia Munoz-Calleja, Arantzazu Alfranca, Isidoro Gonzalez-Alvaro, Jose Maria Galvan-Roman, Javier Aspa, Hortensia de la Fuente, Francisco Sanchez-Madrid
Summary: This study compared plasma miRNA and cytokine profiles between COVID-19 and other community-acquired pneumonias (CAP), revealing 15 dysregulated miRNAs and differential cytokine signatures. These findings provide new insights into the etiopathological mechanisms of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Alvaro Fernando Garcia-Jimenez, Yaiza Caceres-Martell, Daniel Fernandez-Soto, Pedro Martinez Fleta, Jose M. Casasnovas, Francisco Sanchez-Madrid, Jose Miguel Rodriguez Frade, Mar Vales-Gomez, Hugh T. Reyburn
Summary: Several unanswered questions remain about humoral and cellular immunity to SARS-CoV-2, including whether preexisting memory T or B cells in unexposed individuals can recognize and suppress COVID-19. Research has shown that while some unexposed individuals have cross-reactive T cell responses, these responses are weak in aspects like T-FH expansion, which may impact the generation of effective antibodies against SARS-CoV-2. Understanding these differences in cellular responses is crucial for advancing our knowledge of immunity to SARS-CoV-2.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Eva M. Garcia-Cuesta, Jose Miguel Rodriguez-Frade, Sofia R. Gardeta, Gianluca D'Agostino, Pablo Martinez, Blanca Soler Palacios, Graciela Cascio, Tobias Wolf, Nicolas Mateos, Rosa Ayala-Bueno, Cesar A. Santiago, Pilar Lucas, Lucia Llorente, Luis M. Allende, Luis Ignacio Gonzalez-Granado, Noa Martin-Cofreces, Pedro Roda-Navarro, Federica Sallusto, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Laura Martinez-Munoz, Mario Mellado
Summary: This study reveals that the truncated mutant chemokine receptor CXCR4(R334X) associated with WHIM syndrome fails to nanoclusterize after CXCL12 stimulation, affecting cell spatial organization and mobility, and causing multiple phalloidin-positive protrusions in cells. The inappropriate activation of beta-arrestin1 by CXCR4(R334X) leads to inadequate actin cytoskeleton remodeling, disrupting the balance between activated and deactivated cofilin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Laura Esparcia-Pinedo, Ayla Yarci-Carrion, Gloria Mateo-Jimenez, Noelia Ropero, Laura Gomez-Cabanas, Angel Lancho-Sanchez, Patricia Almendro-Vazquez, Enrique Martin-Gayo, Estela Paz-Artal, Francisco Sanchez-Madrid, Fernando Moldenhauer, Ainhoa Gutierrez-Cobos, Diego Real de Asua, Arantzazu Alfranca
Summary: This study found that individuals with Down syndrome (DS) develop an effective immune response to SARS-CoV-2 vaccination. The cellular and humoral responses to the vaccine were observed in DS individuals after 1 to 3 months and 6 months, with an effective immune response observed in 98% of DS individuals after 6 months.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biology
Sara G. Dosil, Sheila Lopez-Cobo, Ana Rodriguez-Galan, Irene Fernandez-Delgado, Marta Ramirez-Huesca, Paula Milan-Rois, Milagros Castellanos, Alvaro Somoza, Manuel Jose Gomez, Hugh T. Reyburn, Mar Vales-Gomez, Francisco Sanchez Madrid, Lola Fernandez-Messina
Summary: NK cells and their secreted EVs have immunomodulatory roles, promoting Th1 responses and activating monocytes and moDCs. MicroRNAs of NK-EVs target molecules involved in Th1 responses and partially recapitulate their effects in mice.
Article
Medicine, General & Internal
Marta Calvet-Mirabent, Ildefonso Sanchez Cerillo, Noa Martin-Corfrees, Pedro Martinez-Fleta, Hortensia de la Fuente, Ilya Tsukalov, Cristina Delgado-Arevelo, Maria Jose Calzo, Ignaciode de los Santos, Jesus Sanz, Lucio Garcia-Fraile, Francisco Sanchez Madid, Arantzazu Alfranca, Maria Angles Munoz-Ferandez, Maria J. Buzon, Enrique Martin-Gayo
Summary: This study identifies specific immunometabolic parameters associated with functional restoration of CD8+ T cells in people living with HIV-1 on long-term ART. The findings suggest that CD8+ T cells from these patients show improved polyfunctionality and capacity to eliminate infected CD4+ T cells after treatment with Gag-adjuvant-primed DC. However, CD8+ T cells from patients on short-term ART show limited functional improvement after DC treatment, which is associated with altered memory cell subsets, increased expression of PD1 and TIGIT, and reduced metabolic activity upon TCR activation. Restoring the function of CD8+ T cells from these patients can be achieved through combined treatment with anti-PD1 and anti-TIGIT antibodies and a glycolysis promoting drug.
Article
Chemistry, Multidisciplinary
Antonella Russo, Hendrik Schuermann, Matthias Brandt, Katja Scholz, Anna Livia L. Matos, David Grill, Julian Revenstorff, Max Rembrink, Meike von Wulffen, Lena Fischer-Riepe, Peter J. Hanley, Hans Haecker, Monika Pruenster, Francisco Sanchez-Madrid, Sven Hermann, Luisa Klotz, Volker Gerke, Timo Betz, Thomas Vogl, Johannes Roth
Summary: It has been demonstrated that S100A8/S100A9 tetramers can weaken the inflammatory response of leukocytes in vitro and in vivo, and this is mediated by the interaction between S100A8/S100A9 tetramers and CD69, rather than the binding of S100A8/S100A9 dimers to TLR4. These findings reveal the important role of the quaternary structure of S100 proteins in regulating leukocyte inflammatory responses.
Article
Immunology
Raul Izquierdo-Serrano, Irene Fernandez-Delgado, Olga Moreno-Gonzalo, Enrique Martin-Gayo, Diego Calzada-Fraile, Marta Ramirez-Huesca, Inmaculada Jorge, Emilio Camafeita, Joaquin Abian, Miguel Vicente-Manzanares, Esteban Veiga, Jesus Vazquez, Francisco Sanchez-Madrid
Summary: Communication through cell-cell contacts and extracellular vesicles allows immune cells to coordinate their responses against pathogens. The proteins and nucleic acids loaded into extracellular vesicles play a crucial role in this process. Acetylation, controlled by HDAC6, is a mechanism of cellular retention during protein sorting to exosomes. During infection, protein content of dendritic cells and their secreted extracellular vesicles change and become enriched in antiviral proteins. These extracellular vesicles can induce anti-pathogenic gene expression in recipient cells, leading to protection against subsequent viral infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Cristina Delgado-Arevalo, Marta Calvet-Mirabent, Ana Triguero-Martinez, Enrique Vazquez de Luis, Alberto Benguria-Filippini, Raquel Largo, Diego Calzada-Fraile, Olga Popova, Ildefonso Sanchez-Cerrillo, Ilya Tsukalov, Roberto Moreno-Vellisca, Hortensia de la Fuente, Gabriel Herrero-Beaumont, Almudena Ramiro, Francisco Sanchez-Madrid, Santos Castaneda, Ana Dopazo, Isidoro Gonzalez alvaro, Enrique Martin-Gayo
Summary: This study assessed the characteristics of CD1c+ and CD141+ cDC and monocytes in patients with RA, revealing the association between the presence of CD1c+ cDC in the synovial membrane and the higher expression of CCR2 and CD64. Additionally, synovial CD1c+ cDC exhibited increased proinflammatory cytokine expression and the ability to induce pathogenic T cells. The crosstalk between Fcγ receptors and NLRC4 was identified as a potential mechanism mediating the pathogenic activation, CD64 upregulation, and functional specialization of CD1c+ cDC in response to dsDNA-IgG in patients with RA.
Article
Multidisciplinary Sciences
Antonio Bouthelier, Lucia Fernandez-Arroyo, Claudia Mesa-Ciller, Danay Cibrian, Noa Beatriz Martin-Cofreces, Raquel Castillo-Gonzalez, Macarena Calero, Diego Herraez-Aguilar, Andrea Guajardo-Grence, Ana Maria Pacheco, Ana Marcos-Jimenez, Borja Quiroga, Marta Morado, Francisco Monroy, Cecilia Munoz-Calleja, Francisco Sanchez-Madrid, Andres A. Urrutia, Julian Aragones
Summary: Inhibition of the amino acid carrier SLC7A5/SLC3A2 has been extensively studied in tumor biology, but its role in physiological conditions is not well understood. This study demonstrates that the SLC7A5/SLC3A2 heterodimer is present during erythroid differentiation but absent in mature red blood cells. Erythropoietin induces expression of SLC7A5/SLC3A2 in reticulocytes, and its deficiency leads to reduced size and hemoglobin content in circulating red blood cells. These findings highlight the importance of SLC7A5/SLC3A2 in reticulocyte maturation and maintaining proper characteristics of red blood cells.
Article
Medicine, Research & Experimental
Rafael Blanco-Dominguez, Hortensia de la Fuente, Cristina Rodriguez, Laura Martin-Aguado, Raquel Sanchez-Diaz, Rosa Jimenez-Alejandre, Iker Rodriguez-Arabaolaza, Andrea Curtabbi, Marcos M. Garcia-Guimaraes, Alberto Vera, Fernando Rivero, Javier Cuesta, Luis J. Jimenez-Borreguero, Alberto Cecconi, Albert Duran-Cambra, Manel Tauron, Judith Alonso, Hector Bueno, Maria Villalba-Orero, Jose Antonio Enriquez, Simon C. Robson, Fernando Alfonso, Francisco Sanchez-Madrid, Jose Martinez-Gonzalez, Pilar Martin
Summary: Increasing CD69 expression on T cells after myocardial infarction may play an important role in controlling immune response and improving cardiac function. Clinical data suggests that increased CD69 expression is associated with a lower risk of heart failure.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Emilia Roy-Vallejo, Laura Cardenoso, Ana Triguero-Martinez, Marta Chicot Llano, Nelly Zurita, Elena Avalos, Ana Barrios, Julia Hernando, Javier Ortiz, Sebastian C. Rodriguez-Garcia, Marianela Ciudad Sanudo, Celeste Marcos, Elena Garcia Castillo, Leticia Fontan Garcia-Rodrigo, Begona Gonzalez, Rosa Mendez, Isabel Iturrate, Ancor Sanz-Garcia, Almudena Villa, Ana Sanchez-Azofra, Begona Quicios, David Arribas, Jesus Alvarez Rodriguez, Pablo Patino, Marina Trigueros, Miren Uriarte, Alexandra Martin-Ramirez, Cristina Arevalo Roman, Jose Maria Galvan-Roman, Rosario Garcia-Vicuna, Julio Ancochea, Cecilia Munoz-Calleja, Elena Fernandez-Ruiz, Rafael de la Camara, Carmen Suarez Fernandez, Isidoro Gonzalez-Alvaro, Diego A. Rodriguez-Serrano, PREDINMUN COVID Grp
Summary: This study aimed to evaluate the relationship between SARS-CoV-2 viral load and IL6 levels in COVID-19 patients. The results showed that in patients with worse outcomes, there was an early peak of SARS-CoV-2 viral load followed by an increase in IL6 levels. Monitoring viral load during the first week after symptom onset may help predict disease severity in COVID-19 patients.
FRONTIERS IN MEDICINE
(2022)
