Article
Gastroenterology & Hepatology
Chang Li, Yuning Zhou, Ruozheng Wei, Dana L. Napier, Tomoko Sengoku, Michael C. Alstott, Jinpeng Liu, Chi Wang, Yekaterina Y. Zaytseva, Heidi L. Weiss, Qingding Wang, B. Mark Evers
Summary: Our findings indicate that glycolytic activity is essential for maintaining the self-renewal of intestinal stem cells (ISCs), and inhibiting glycolysis contributes to the differentiation of secretory lineages from ISCs. The dysregulation of glycolysis in ISCs disrupts the balance between self-renewal and differentiation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Developmental Biology
William B. Tu, Heather R. Christofk, Kathrin Plath
Summary: Diet plays a crucial role in maintaining health throughout life, influencing cell fate decisions, maintaining tissue homeostasis, and mitigating the effects of aging. This review highlights the impact of common diets and specific nutrients on cell fate decisions in both healthy and disease contexts, as well as the potential of new models, technologies, and resources to advance dietary approaches for promoting healthy development and improving disease treatments.
Review
Cell Biology
Carmen Rodriguez, Noelia Puente-Moncada, Russel J. Reiter, Ana M. Sanchez-Sanchez, Federico Herrera, Jezabel Rodriguez-Blanco, Cristina Duarte-Olivenza, Maria Turos-Cabal, Isaac Antolin, Vanesa Martin
Summary: Multiple oncogenic pathways and local microenvironmental conditions converge on regulating cancer cell metabolism, with melatonin considered a therapeutic target due to its reported antitumor effects. High concentrations of melatonin have shown effectiveness in reducing cell growth and inducing cell death in certain types of tumors, suggesting its potential role in regulating glucose metabolism in cancer cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Ioannis Stouras, Maria Vasileiou, Panagiotis F. Kanatas, Eleni Tziona, Christina Tsianava, Stamatis Theocharis
Summary: In this review, the metabolic characteristics of cancer stem cells (CSCs) and normal stem cells are summarized, highlighting the significance and potential clinical value of CSC metabolism interventions.
Review
Cell Biology
Satish Kumar Tiwari, Sudip Mandal
Summary: Over the years, Drosophila has been a valuable genetic model system to study tissue-resident stem cells, with recent advancements in understanding the contribution of mitochondria to governing stem cell properties.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kaya L. Persad, Gary D. Lopaschuk
Summary: Changes in energy metabolism have significant impacts on the fate of cardiomyocytes during development, particularly during the transition to a mature state. Mitochondrial biogenesis is regulated by fatty acid oxidation and PGC1-alpha, playing crucial roles in cardiac development and cell fate. Adult stem cells may secrete factors that protect cardiomyocytes, aiding in their differentiation and survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Immunology
Paola de Candia, Giuseppe Matarese
Summary: This study reveals the role of folate-dependent one carbon metabolism enzyme MTHFD2 in CD4(+) T cell polarization and suggests its involvement in suppressing pro-inflammatory T cells while promoting regulatory T cells.
Article
Biochemistry & Molecular Biology
Otto Morris, Heinrich Jasper
Summary: Reactive Oxygen Species (ROS) play critical signaling roles in the intestine, maintaining the regenerative capacity of Intestinal Stem Cells (ISCs). Declines in metabolic adaptations, through aging or pathology, result in reciprocal changes in ISC metabolism and ROS signaling, ultimately leading to aberrant ISC function and loss of tissue homeostasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Muxin Yue, Yunsong Liu, Ping Zhang, Zheng Li, Yongsheng Zhou
Summary: The study investigates the interaction between stem cell transcriptional and metabolic signals in extracellular matrices with different stiffnesses. It reveals that the stiffness of the matrix plays a role in determining the fate of bone marrow mesenchymal stem cells, with different stiffnesses leading to different differentiation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ilario Amato, Sebastien Meurant, Patricia Renard
Summary: The study focuses on the mechanisms of stem cell differentiation, including the switch in metabolism from glycolytic to oxidative metabolism. Recent research has discovered the asymmetric distribution of mitochondria in stem cell progeny, which has sparked great interest in the field. This review summarizes the regulation of mitochondrial asymmetric apportioning through fusion, fission, and mitophagy processes, and emphasizes the impact of asymmetric mitochondrial apportioning on stem cell metabolism, epigenetics, and cell fate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Nima K. Emami, Reagan N. Cauble, Ahmed E. Dhamad, Elizabeth S. Greene, Cynthia S. Coy, Sandra G. Velleman, Sara Orlowski, Nicholas Anthony, Mike Bedford, Sami Dridi
Summary: The Woody Breast condition poses challenges to the global poultry industry with no effective treatment currently available. Research suggests that satellite cells in affected birds may undergo a shift in fate under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda
Summary: By studying the mitochondrial metabolism and ATP citrate lyase (ACLY) in hematopoietic stem cells (HSCs), we have gained new insights into the regulation of HSCs during hematopoietic regeneration.
Review
Cell Biology
Yuting Wang, Wei Wu, Jianke Gong
Summary: Micronutrients have a strong relationship with cell death and play a crucial role in maintaining human body health. Dysregulation of micronutrients can lead to various metabolic or chronic diseases such as obesity, cardiometabolic conditions, neurodegeneration, and cancer. The nematode Caenorhabditis elegans offers a valuable genetic model for studying the effects of micronutrients on metabolism, healthspan, and lifespan. Moreover, its characteristics like specific haem trafficking pathway and ease of studying different forms of cell death make it an excellent tool for understanding the underlying mechanisms. A comprehensive understanding of micronutrient metabolism and cell death not only helps in developing better treatments for micronutrient disorders but also provides insights into human health and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiexiang Zhao, Ping Lu, Cong Wan, Yaping Huang, Manman Cui, Xinyan Yang, Yuqiong Hu, Yi Zheng, Ji Dong, Mei Wang, Shu Zhang, Zhaoting Liu, Shuhui Bian, Xiaoman Wang, Rui Wang, Shaofang Ren, Dazhuang Wang, Zhaokai Yao, Gang Chang, Fuchou Tang, Xiao-Yang Zhao
Summary: Through single-cell sequencing, the study investigates the transcriptome landscapes of mouse male germ cells throughout development and identifies critical regulators for prenatal cell-fate determination.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Nick van Gastel, Geert Carmeliet
Summary: The skeleton serves diverse functions through an interplay of different cell types, including osteoblasts, chondrocytes, bone marrow adipocytes, and stromal cells. Cellular metabolism plays a crucial role in determining skeletal stem cell fate, coordinating osteoblast and chondrocyte function, and organizing stromal support of haematopoiesis. Metabolic dysregulation may contribute to skeletal ageing and degenerative diseases, highlighting the importance of understanding the roles of cellular metabolism in skeletal biology.
Review
Cell & Tissue Engineering
James G. Ryall, Tim Cliff, Stephen Dalton, Vittorio Sartorelli
Article
Cell & Tissue Engineering
James G. Ryall, Stefania Dell'Orso, Assia Derfoul, Aster Juan, Hossein Zare, Xuesong Feng, Daphney Clermont, Miroslav Koulnis, Gustavo Gutierrez-Cruz, Marcella Fulco, Vittorio Sartorelli
Article
Neurosciences
Benjamin D. Rowlands, Chew Ling Lau, James G. Ryall, Donald S. Thomas, Matthias Klugmann, Philip M. Beart, Caroline D. Rae
JOURNAL OF NEUROSCIENCE RESEARCH
(2015)
Article
Oncology
Christina Molck, James Ryall, Laura M. Failla, Janine L. Coates, Jean-Marc Pascussi, Joan K. Heath, Gregory Stewart, Frederic Hollande
Article
Oncology
Julie Giraud, Laura M. Failla, Jean-Marc Pascussi, Ebba L. Lagerqvist, Jeremy Ollier, Pascal Finetti, Francois Bertucci, Chu Ya, Imene Gasmi, Jean-Francois Bourgaux, Michel Prudhomme, Thibault Mazard, Imade Ait-Arsa, Leila Houhou, Daniel Birnbaum, Andre Pelegrin, Charles Vincent, James G. Ryall, Dominique Joubert, Julie Pannequin, Frederic Hollande
Review
Cell & Tissue Engineering
Rhianna C. Laker, James G. Ryall
STEM CELLS INTERNATIONAL
(2016)
Editorial Material
Cell & Tissue Engineering
Giuseppina Caretti, Libera Berghella, Aster Juan, Lucia Latella, James Ryall
STEM CELLS INTERNATIONAL
(2016)
Review
Biology
Savant S. Thakur, Kristy Swiderski, James G. Ryall, Gordon S. Lynch
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Richard J. Mills, Drew M. Titmarsh, Xaver Koenig, Benjamin L. Parker, James G. Ryall, Gregory A. Quaife-Ryan, Holly K. Voges, Mark P. Hodson, Charles Ferguson, Lauren Drowley, Alleyn T. Plowright, Elise J. Needham, Qing-Dong Wang, Paul Gregorevic, Mei Xin, Walter G. Thomas, Robert G. Parton, Lars K. Nielsen, Bradley S. Launikonis, David E. James, David A. Elliott, Enzo R. Porrello, James E. Hudson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Medicine, General & Internal
Sung-Jun Park, Faiyaz Ahmad, Jee-Hyun Um, Alexandra L. Brown, Xihui Xu, Hyeog Kang, Hengming Ke, Xuesong Feng, James Ryall, Andrew Philp, Simon Schenk, Myung K. Kim, Vittorio Sartorelli, Jay H. Chung
Review
Endocrinology & Metabolism
James G. Ryall, Gordon S. Lynch
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2018)
Article
Multidisciplinary Sciences
Jarrod E. Church, Jennifer Trieu, Radhika Sheorey, Annabel Y. -M. Chee, Timur Naim, Dale M. Baum, James G. Ryall, Paul Gregorevic, Gordon S. Lynch
Review
Physiology
Rene Koopman, C. Hai Ly, James G. Ryall
FRONTIERS IN PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Yea Seul Shin, James G. Ryall, Joanne M. Britto, Chew L. Lau, Rodney J. Devenish, Phillip Nagley, Philip M. Beart
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Jonathan R. Davey, Kevin I. Watt, Benjamin L. Parker, Rima Chaudhuri, James G. Ryall, Louise Cunningham, Hongwei Qian, Vittorio Sartorelli, Marco Sandri, Jeffrey Chamberlain, David E. James, Paul Gregorevic