Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration

Histone deacetylase 9 downregulation decreases tumor growth and promotes apoptosis in NSCLC after melatonin treatment

(2019) Zhiqiang Ma et al.   JOURNAL OF PINEAL RESEARCH

Dietary Supplementation of Vine Tea Ameliorates Glucose and Lipid Metabolic Disorder via Akt Signaling Pathway in Diabetic Rats

(2019) Jiamei Xiang et al.   MOLECULES

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

(2018) Eunae Sandra Cho et al.   Biomolecules & Therapeutics

Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor

(2018) Ji-Chang Wang et al.   CANCER SCIENCE

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

(2018) Ying-Qiang Shen et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia

(2018) Noelia Puente-Moncada et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

(2018) Meng-Xi Liu et al.   ONCOGENE

Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role

(2018) Yan Mi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

(2017) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study

(2017) David Hevia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

(2017) H-Q Ju et al.   LEUKEMIA

Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines

(2017) Gabriela Bottaro Gelaleti et al.   LIFE SCIENCES

The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

(2017) Haizhen Wang et al.   NATURE

Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma

(2017) S Luo et al.   ONCOGENE

Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy

(2017) Hester Rijkje Berger et al.   PLoS One

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy

(2017) Néstor Prieto-Domínguez et al.   Oncotarget

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

(2016) Rigel J. Kishton et al.   Cell Metabolism

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

(2016) Néstor Prieto-Domínguez et al.   JOURNAL OF PINEAL RESEARCH

Quantitative Proteomic Profiling Reveals That Diverse Metabolic Pathways Are Influenced by Melatonin in an in Vivo Model of Ovarian Carcinoma

(2016) Luiz Gustavo A. Chuffa et al.   JOURNAL OF PROTEOME RESEARCH

A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma

(2016) Thomas W. Lycan et al.   PLoS One

Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells

(2016) JUCIMARA COLOMBO et al.   Oncology Letters

Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt

(2016) Cecilia Marini et al.   Scientific Reports

Novel Therapeutic Targets of Tumor Metabolism

(2015) Rigel J. Kishton et al.   CANCER JOURNAL

Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma

(2015) Lulu Mao et al.   JOURNAL OF PINEAL RESEARCH

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

(2015) Emma E. Vincent et al.   MOLECULAR CELL

Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells

(2015) Rute Loureiro et al.   Oncotarget

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells

(2015) Ana M. Sanchez-Sanchez et al.   PLoS One

Molecular Markers of Angiogenesis and Metastasis in Lines of Oral Carcinoma after Treatment with Melatonin

(2014) Naiane Goncalves et al.   Anti-Cancer Agents in Medicinal Chemistry

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

(2014) Ji-Won Park et al.   BMC CANCER

Biliverdin’s regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer

(2014) J Zheng et al.   BRITISH JOURNAL OF CANCER

Overcoming Hypoxic-Resistance of Tumor Cells to TRAIL-Induced Apoptosis through Melatonin

(2014) You-Jin Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability

(2014) Andrés Méndez-Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructural aspects of melatonin cytotoxicity on Caco-2 cells in vitro

(2014) Ana Paula C. Batista et al.   MICRON

Gluconeogenesis in cancer: Door wide open

(2014) Katharina Leithner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked?

(2013) Romana Stark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanisms Involved in the Pro-Apoptotic Effect of Melatonin in Cancer Cells

(2013) Carmen Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma

(2013) Ruihua Ma et al.   Nature Communications

Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells

(2012) Jin-Qiang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin

(2012) G García-Santos et al.   BRITISH JOURNAL OF CANCER

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer

(2012) Christopher J. Ricketts et al.   JOURNAL OF UROLOGY

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

(2012) Joffrey Pelletier et al.   Frontiers in Oncology

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells

(2011) Ana M. Sánchez-Sánchez et al.   FREE RADICAL RESEARCH

Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients

(2011) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Pro-Oxidant Effect of Melatonin in Tumour Leucocytes: Relation with its Cytotoxic and Pro-Apoptotic Effects

(2010) Ignacio Bejarano et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death

(2009) Vanesa Martín et al.   CANCER LETTERS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer

(2009) Seong Soo Joo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin down-regulates HIF-1α expression through inhibition of protein translation in prostate cancer cells

(2009) Jong-Wook Park et al.   JOURNAL OF PINEAL RESEARCH

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

(2009) D A Tennant et al.   ONCOGENE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

(2008) Javier Martín-Renedo et al.   JOURNAL OF PINEAL RESEARCH

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY