The enzymes of human diphosphoinositol polyphosphate metabolism

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3for polyphosphoinositide-binding domains

(2013) Nikhil A. Gokhale et al.   BIOCHEMICAL JOURNAL

When worlds collide: inositol pyrophosphates and phosphoinositides intersect at the plasma membrane: Figure 1

(2013) Christophe Erneux et al.   BIOCHEMICAL JOURNAL

Inositol pyrophosphates: between signalling and metabolism

(2013) Miranda S. C. Wilson et al.   BIOCHEMICAL JOURNAL

Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels

(2013) S. Ghosh et al.   BLOOD

Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs

(2013) Rajagopal S. Kilari et al.   FEBS LETTERS

Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates inSaccharomyces cerevisiae

(2013) Cunqi Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity

(2013) B. P. Roland et al.   JOURNAL OF CELL SCIENCE

A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

(2013) S C Falcon et al.   Oncogenesis

Inositol polyphosphate multikinase signaling in the regulation of metabolism

(2012) Joo-Young Lee et al.   Annals of the New York Academy of Sciences

Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis

(2012) Torsten Wundenberg et al.   BIOLOGICAL CHEMISTRY

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

(2012) Jeremy D. Weaver et al.   BIOSCIENCE REPORTS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

(2012) Andrew M. Riley et al.   CHEMICAL COMMUNICATIONS

Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

(2012) J. S. Logue et al.   GENES & DEVELOPMENT

The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

(2012) Edmond M. Linossi et al.   IUBMB LIFE

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair

(2012) Rathan S. Jadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies and Protein Engineering of Inositol Phosphate Multikinase

(2012) Stuart Endo-Streeter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile

(2012) Pamela V. Tran et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain

(2011) Nikhil A. Gokhale et al.   BIOCHEMICAL JOURNAL

The secret life of kinases: functions beyond catalysis

(2011) Jens Rauch et al.   Cell Communication and Signaling

Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease

(2011) Eiichiro Nagata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment

(2011) Alexey E. Alekseev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Toward an understanding of the protein interaction network of the human liver

(2011) J. Wang et al.   Molecular Systems Biology

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

(2011) Huanchen Wang et al.   Nature Chemical Biology

Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

(2011) Amit Prasad et al.   NATURE IMMUNOLOGY

Next-generation sequencing to generate interactome datasets

(2011) Haiyuan Yu et al.   NATURE METHODS

The IntAct molecular interaction database in 2012

(2011) S. Kerrien et al.   NUCLEIC ACIDS RESEARCH

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2

(2011) A. Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol Pyrophosphates as Mammalian Cell Signals

(2011) A. Chakraborty et al.   Science Signaling

SnapShot: Inositol Phosphates

(2010) Ace J. Hatch et al.   CELL

Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

(2010) Anutosh Chakraborty et al.   CELL

Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects

(2010) Marino Muxfeldt Bianchin et al.   Current Pain and Headache Reports

Inositol hexakisphosphate kinases promote autophagy

(2010) Eiichiro Nagata et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: Structure, synthesis, and development of probes for studying biological activity

(2010) Michael D. Best et al.   NATURAL PRODUCT REPORTS

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2

(2010) M. A. Koldobskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway

(2010) B. Sarmah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lys-N and Trypsin Cover Complementary Parts of the Phosphoproteome in a Refined SCX-Based Approach

(2009) Sharon Gauci et al.   ANALYTICAL CHEMISTRY

Inositol pyrophosphates modulate hydrogen peroxide signalling

(2009) Sara Maria Nancy Onnebo et al.   BIOCHEMICAL JOURNAL

Glycogen synthase kinase 3: more than a namesake

(2009) Geetha Vani Rayasam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inositol pyrophosphates: structure, enzymology and function

(2009) Christopher John Barker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases

(2009) Usha Padmanabhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are inositolpyrophosphates signalling molecules?

(2009) Adam Burton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diphosphoinositol Polyphosphates: Metabolic Messengers?

(2009) S. B. Shears   MOLECULAR PHARMACOLOGY

Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma

(2009) B H Morrison et al.   ONCOGENE

Crystal structure of human diphosphoinositol phosphatase 1

(2009) Ann-Gerd Thorsell et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Automated Phosphoproteome Analysis for Cultured Cancer Cells by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column

(2008) Koshi IMAMI et al.   ANALYTICAL SCIENCES

Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups

(2008) Petra Draškovič et al.   CHEMISTRY & BIOLOGY

Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases

(2008) Hongying Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combining Protein-Based IMAC, Peptide-Based IMAC, and MudPIT for Efficient Phosphoproteomic Analysis

(2008) Greg T. Cantin et al.   JOURNAL OF PROTEOME RESEARCH

An empirical framework for binary interactome mapping

(2008) Kavitha Venkatesan et al.   NATURE METHODS

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2

(2008) A. Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis

(2008) R. Bhandari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA