Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoid-induced leucine zipper? A perspective

A1.38 Mesenchymal stem cells induce non-classical IL-10-producing regulatory TH17 cells in arthritis: role of gilz

(2014) P Luz-Crawford et al.   ANNALS OF THE RHEUMATIC DISEASES

A8.11 gilz-dependent activin a production by MSC inhibits TH17 differentiation

(2014) P Luz-Crawford et al.   ANNALS OF THE RHEUMATIC DISEASES

A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis

(2014) P. Dewint et al.   JOURNAL OF IMMUNOLOGY

GILZ Promotes Production of Peripherally Induced Treg Cells and Mediates the Crosstalk between Glucocorticoids and TGF-β Signaling

(2014) Oxana Bereshchenko et al.   Cell Reports

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

(2013) Megan Murray et al.   CELL CYCLE

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

(2013) Karolien De Bosscher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by theTsc22d3gene on the X chromosome

(2013) Iris Pinheiro et al.   EMBO Molecular Medicine

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation

(2013) Sofie Vandevyver et al.   ENDOCRINOLOGY

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glucocorticoids Antagonize RUNX2 During Osteoblast Differentiation in Cultures of ST2 Pluripotent Mesenchymal Cells

(2013) Theodora Koromila et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GILZ Overexpression Inhibits Endothelial Cell Adhesive Function through Regulation of NF- B and MAPK Activity

(2013) Q. Cheng et al.   JOURNAL OF IMMUNOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Dexamethasone Inhibits Repair of Human Airway Epithelial Cells Mediated by Glucocorticoid-Induced Leucine Zipper (GILZ)

(2013) Jingyue Liu et al.   PLoS One

Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

(2013) Ilse M. Beck et al.   PLoS One

HES1 Is a Master Regulator of Glucocorticoid Receptor-Dependent Gene Expression

(2013) J. R. Revollo et al.   Science Signaling

MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases

(2013) Sara De Iudicibus   WORLD JOURNAL OF GASTROENTEROLOGY

Crosstalk between NFkB and glucocorticoid signaling: A potential target of breast cancer therapy

(2012) Jun Ling et al.   CANCER LETTERS

Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation

(2012) Jessica Hoppstädter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways

(2012) Emira Ayroldi et al.   FASEB JOURNAL

Anti-inflammatory Effects of Mapracorat, a Novel Selective Glucocorticoid Receptor Agonist, Is Partially Mediated by MAP Kinase Phosphatase-1 (MKP-1)

(2012) Thomas R. Vollmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-Induced Leucine Zipper (GILZ) Antagonizes TNF-α Inhibition of Mesenchymal Stem Cell Osteogenic Differentiation

(2012) Linlin He et al.   PLoS One

Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells

(2012) Ana C. Liberman et al.   PLoS One

Yersinia enterocolitica YopT and Clostridium difficile Toxin B Induce Expression of GILZ in Epithelial Cells

(2012) Martin Köberle et al.   PLoS One

Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

(2012) Marie-José C. van Lierop et al.   PLoS One

The Glucocorticoid-Induced Leucine Zipper (GILZ) Is Essential for Spermatogonial Survival and Spermatogenesis

(2012) Y. Romero et al.   Sexual Development

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide

(2011) MM Kelly et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1

(2011) Eugénie Joanny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long Glucocorticoid-induced Leucine Zipper (L-GILZ) Protein Interacts with Ras Protein Pathway and Contributes to Spermatogenesis Control

(2011) Stefano Bruscoli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel p65 Binding Glucocorticoid-induced Leucine Zipper Peptide Suppresses Experimental Autoimmune Encephalomyelitis

(2011) Mythily Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid non-genomic effects of corticosteroids and their role in the central stress response

(2011) Femke L Groeneweg et al.   JOURNAL OF ENDOCRINOLOGY

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells

(2011) S Joha et al.   ONCOGENE

Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

(2011) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Identification of the Chemokine CX3CL1 as a New Regulator of Malignant Cell Proliferation in Epithelial Ovarian Cancer

(2011) Françoise Gaudin et al.   PLoS One

Dynamic regulation of glucocorticoid signalling in health and disease

(2011) S. C. Biddie et al.   RHEUMATOLOGY

Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

(2010) Elaine Beaulieu et al.   ARTHRITIS AND RHEUMATISM

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: Survival of the fittest regulator of the immune system?

(2010) Karolien De Bosscher et al.   BRAIN BEHAVIOR AND IMMUNITY

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Targeting inflammation using selective glucocorticoid receptor modulators

(2010) Karolien De Bosscher et al.   CURRENT OPINION IN PHARMACOLOGY

Ethanol Upregulates Glucocorticoid-Induced Leucine Zipper Expression and Modulates Cellular Inflammatory Responses in Lung Epithelial Cells

(2010) M. Gomez et al.   JOURNAL OF IMMUNOLOGY

The role of the glucocorticoid receptor in inflammation and immunity

(2010) Ulrike Baschant et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Glucocorticoid receptor (GR) β has intrinsic, GRα-independent transcriptional activity

(2009) Tomoshige Kino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

(2009) H Schäcke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human glucocorticoid receptor isoform β: recent understanding of its potential implications in physiology and pathophysiology

(2009) Tomoshige Kino et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

(2009) Ilse M. E. Beck et al.   ENDOCRINE REVIEWS

Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action

(2009) Emira Ayroldi et al.   FASEB JOURNAL

Abrogation of Glucocorticoid Receptor Dimerization Correlates with Dissociated Glucocorticoid Behavior of Compound A

(2009) Steven Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer

(2009) Nassima Redjimi et al.   Molecular Cancer

Therapeutic and Adverse Effects of a Non-Steroidal Glucocorticoid Receptor Ligand in a Mouse Model of Multiple Sclerosis

(2009) Simone Wüst et al.   PLoS One

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

What goes on behind closed doors: physiological versus pharmacological steroid hormone actions

(2008) S. Stoney Simons   BIOESSAYS

Combining 3D-QSAR, docking, molecular dynamics and MM/PBSA methods to predict binding modes for nonsteroidal selective modulator to glucocorticoid receptor

(2008) Yong Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glucocorticoid-Induced Leucine Zipper Is Protective in Th1-Mediated Models of Colitis

(2008) Lorenza Cannarile et al.   GASTROENTEROLOGY

Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma

(2008) Katharine D. Grugan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Interaction of the Glucocorticoid Receptor with the Chromatin Landscape

(2008) Sam John et al.   MOLECULAR CELL

Cross Talk of Signaling Pathways in the Regulation of the Glucocorticoid Receptor Function

(2008) Laura Davies et al.   MOLECULAR ENDOCRINOLOGY

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

(2008) Karolien De Bosscher et al.   MOLECULAR ENDOCRINOLOGY

The glucocorticoid receptor β isoform can mediate transcriptional repression by recruiting histone deacetylases

(2007) Audrey Kelly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression

(2007) Nianlan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY