Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

Essential role of interleukin-6 in post-stroke angiogenesis

(2012) Karen Gertz et al.   BRAIN

PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury

(2012) Koichi Arimura et al.   CURRENT NEUROVASCULAR RESEARCH

Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury

(2012) R. A. Stetler et al.   JOURNAL OF NEUROSCIENCE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

(2012) Takashi Shichita et al.   NATURE MEDICINE

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia

(2011) Bolanle M. Famakin et al.   BRAIN RESEARCH

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury

(2011) Conrad A. Farrar et al.   FASEB JOURNAL

The role of free radical generation in increasing cerebrovascular permeability

(2011) Paul A. Fraser   FREE RADICAL BIOLOGY AND MEDICINE

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

(2011) Yasutaka Motomura et al.   NATURE IMMUNOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Suppressing Immunosuppression after Stroke

(2011) Christian Meisel et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia

(2011) Arthur Liesz et al.   PLoS One

Monocyte Chemoattractant Protein-1-Deficiency Impairs the Expression of IL-6, IL-1β and G-CSF after Transient Focal Ischemia in Mice

(2011) Jan-Kolja Strecker et al.   PLoS One

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

(2011) C. H. Y. Wong et al.   SCIENCE

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

Neuroprotection by Interleukin-6 Is Mediated by Signal Transducer and Activator of Transcription 3 and Antioxidative Signaling in Ischemic Stroke

(2011) Joo Eun Jung et al.   STROKE

Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia

(2011) Xiaoxing Xiong et al.   STROKE

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

(2010) Kazuhide Hayakawa et al.   Annals of the New York Academy of Sciences

Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?

(2010) Anna Morancho et al.   Annals of the New York Academy of Sciences

Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model

(2010) Fumie Konoeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain Pericytes: Emerging Concepts and Functional Roles in Brain Homeostasis

(2010) Masahiro Kamouchi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Extracellular Fluid Protein Changes in Acute Stroke Patients

(2010) Loïc Dayon et al.   JOURNAL OF PROTEOME RESEARCH

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Degeneration and repair in central nervous system disease

(2010) Eng H Lo   NATURE MEDICINE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteomic investigation of a neural substrate intimately related to brain death

(2010) Jimmy Li-Jer Chou et al.   PROTEOMICS

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo

(2009) J. Rashidian et al.   JOURNAL OF NEUROSCIENCE

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia

(2009) Yasuko Terao et al.   NEUROSCIENCE RESEARCH

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

(2009) T. Okamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant T Cell Receptor Ligand Treats Experimental Stroke

(2009) Sandhya Subramanian et al.   STROKE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

TLR accessory molecules

(2008) Sachiko Akashi-Takamura et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Sensitization and tolerization to brain antigens in stroke

(2008) K.J. Becker   NEUROSCIENCE

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion

(2008) Satoshi Terao et al.   STROKE

Astrocytes and Ischemic Injury

(2008) T. Takano et al.   STROKE

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

(2007) Kumlesh K. Dev et al.   PHARMACOLOGY & THERAPEUTICS

Analysis of Lymphocyte Subsets in Patients With Stroke and Their Influence on Infection After Stroke

(2007) Antje Vogelgesang et al.   STROKE