Age-Related Progressive Synaptic Dysfunction: The Critical Role of Presenilin 1

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing

(2009) V. B. Kumar et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease

(2009) A. Auffret et al.   JOURNAL OF NEUROSCIENCE

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

(2009) Ganesh M. Shankar et al.   NEUROBIOLOGY OF DISEASE

Toward Structural Elucidation of the γ-Secretase Complex

(2009) Huilin Li et al.   STRUCTURE

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin-1 Mutant Mice

(2003) James G. Begley et al.   JOURNAL OF NEUROCHEMISTRY