Molecular basis of iron-loading disorders

Development of a novel immunoassay for the iron regulatory peptide hepcidin

(2016) M. Busbridge et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

Hemochromatosis and pregnancy: iron stores in the Hfe−/− mouse are not reduced by multiple pregnancies

(2010) João Vilares Neves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

(2010) K. E. Finberg et al.   BLOOD

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

(2010) J. Gao et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Anemia of Chronic Disease (Anemia of Inflammation)

(2009) Neeraj Agarwal et al.   ACTA HAEMATOLOGICA

The Role of Hepcidin in Iron Metabolism

(2009) Elizabeta Nemeth et al.   ACTA HAEMATOLOGICA

Regulation of Hepcidin and Iron-Overload Disease

(2009) Pauline L. Lee et al.   Annual Review of Pathology-Mechanisms of Disease

Regulatory variation in hepcidin expression as a heritable quantitative trait

(2009) Henry K. Bayele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A genome-wide association analysis of serum iron concentrations

(2009) T. Tanaka et al.   BLOOD

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

Stoichiometries of transferrin receptors 1 and 2 in human liver

(2009) Maja Chloupková et al.   BLOOD CELLS MOLECULES AND DISEASES

High-sensitive radioimmunoassay for human serum hepcidin

(2009) Nicolai Grebenchtchikov et al.   BRITISH JOURNAL OF HAEMATOLOGY

Suppression of the hepcidin-encoding geneHamppermits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

(2009) Jaroslav Truksa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization

(2009) J. J.C. Kroot et al.   HAEMATOLOGICA

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist

(2009) M. van Deuren et al.   HAEMATOLOGICA

Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major

(2009) M. Andreani et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

A Case of Iron Overload Cardiomyopathy

(2009) Kazuro Sugishita et al.   International Heart Journal

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

(2009) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin Decreases Iron Transporter Expression in Vivo in Mouse Duodenum and Spleen and in Vitro in THP-1 Macrophages and Intestinal Caco-2 Cells

(2009) Bomee Chung et al.   JOURNAL OF NUTRITION

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

(2009) Santhi K Ganesh et al.   NATURE GENETICS

Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate

(2009) H. P.E. Peters et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Is iron overload in alcohol-related cirrhosis mediated byhepcidin?

(2009) Tariq Iqbal et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

(2009) Hongyan Li et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women

(2008) Melissa F Young et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Variants in TF and HFE Explain ∼40% of Genetic Variation in Serum-Transferrin Levels

(2008) Beben Benyamin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Forging a field: the golden age of iron biology

(2008) N. C. Andrews   BLOOD

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

(2008) F. Guillem et al.   BLOOD

Iron depletion limits intracellular bacterial growth in macrophages

(2008) P. N. Paradkar et al.   BLOOD

Serum hepcidin levels are innately low inHFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels

(2008) Boukje A. C. van Dijk et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hfe Acts in Hepatocytes to Prevent Hemochromatosis

(2008) Maja Vujić Spasić et al.   Cell Metabolism

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Post-prandial iron absorption in humans: Comparison between HFE genotypes and iron deficiency anaemia

(2008) Carol Hutchinson et al.   CLINICAL NUTRITION

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Regulation of Iron Absorption in Hemoglobinopathies

(2008) Gideon Rechavi et al.   CURRENT MOLECULAR MEDICINE

Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation

(2008) J. Kanda et al.   HAEMATOLOGICA

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Iron-Overload–Related Disease inHFEHereditary Hemochromatosis

(2008) Katrina J. Allen et al.   NEW ENGLAND JOURNAL OF MEDICINE

SELDI-TOF-MS determination of hepcidin in clinical samples using stable isotope labelled hepcidin as an internal standard

(2008) Douglas G Ward et al.   Proteome Science

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Clinical application of deferasirox: Practical patient management

(2007) Elliott Vichinsky   AMERICAN JOURNAL OF HEMATOLOGY

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD