Vaccine adjuvant uses of poly-IC and derivatives

Combinatorial Immunotherapy of Polyinosinic–Polycytidylic Acid and Blockade of Programmed Death-Ligand 1 Induce Effective CD8 T-cell Responses against Established Tumors

(2014) Toshihiro Nagato et al.   CLINICAL CANCER RESEARCH

Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

(2014) Aaron P. Rapoport et al.   CLINICAL CANCER RESEARCH

Immunomodulatory properties of the vaccine adjuvant alum

(2014) Ewa Oleszycka et al.   CURRENT OPINION IN IMMUNOLOGY

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN- / 

(2014) S. M. Ngoi et al.   JOURNAL OF IMMUNOLOGY

FLT3-Ligand Treatment of Humanized Mice Results in the Generation of Large Numbers of CD141+ and CD1c+ Dendritic Cells In Vivo

(2014) Y. Ding et al.   JOURNAL OF IMMUNOLOGY

dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects

(2014) Saurabh Chattopadhyay et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Toll-Like Receptor Agonist Augments Virus-Like Particle-Mediated Protection from Ebola Virus with Transient Immune Activation

(2014) Karen A. O. Martins et al.   PLoS One

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Immune Checkpoint Blockade in Cancer Treatment: A Double-Edged Sword Cross-Targeting the Host as an “Innocent Bystander”

(2014) Lucia Gelao et al.   Toxins

Therapeutic In Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case Report, Hypothesis, and Clinical Trial

(2014) A. M. Salazar et al.   Cancer Immunology Research

Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

(2013) Annina M. Hafner et al.   ADVANCED DRUG DELIVERY REVIEWS

Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity

(2013) R. Perret et al.   CANCER RESEARCH

Pathogen-like particles: biomimetic vaccine carriers engineered at the nanoscale

(2013) Joseph A. Rosenthal et al.   CURRENT OPINION IN BIOTECHNOLOGY

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

(2013) Olga Vera-Lastra et al.   Expert Review of Clinical Immunology

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis

(2013) Jian Zou et al.   IMMUNITY

Pattern-Recognition Receptor Signaling Regulator mRNA Expression in Humans and Mice, and in Transient Inflammation or Progressive Fibrosis

(2013) Roman Günthner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD141+ myeloid dendritic cells are enriched in healthy human liver

(2013) Aoife Kelly et al.   JOURNAL OF HEPATOLOGY

Polyinosinic-Polycytidylic Acid Is the Most Effective TLR Adjuvant for SIV Gag Protein-Induced T Cell Responses In Nonhuman Primates

(2013) H. Park et al.   JOURNAL OF IMMUNOLOGY

Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type

(2013) M. Firoz Mian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pediatric Phase II Trials of Poly-ICLC in the Management of Newly Diagnosed and Recurrent Brain Tumors

(2013) Lisa L.R. Hartman et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

(2013) Wendy Peters et al.   VACCINE

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

(2012) Vijaya B. Joshi et al.   AAPS Journal

An Adenovirus-Based Vaccine with a Double-Stranded RNA Adjuvant Protects Mice and Ferrets against H5N1 Avian Influenza in Oral Delivery Models

(2012) Ciaran D. Scallan et al.   Clinical and Vaccine Immunology

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

(2012) P. Sabbatini et al.   CLINICAL CANCER RESEARCH

Modulation of T-cell function by type I interferon

(2012) David F Tough   IMMUNOLOGY AND CELL BIOLOGY

Full-Length Plasmodium falciparum Circumsporozoite Protein Administered with Long-Chain Poly(I·C) or the Toll-Like Receptor 4 Agonist Glucopyranosyl Lipid Adjuvant-Stable Emulsion Elicits Potent Antibody and CD4+T Cell Immunity and Protection in Mice

(2012) Kathrin Kastenmüller et al.   INFECTION AND IMMUNITY

Vaccine Injection Site Matters: Qualitative and Quantitative Defects in CD8 T Cells Primed as a Function of Proximity to the Tumor in a Murine Glioma Model

(2012) J. R. Ohlfest et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients

(2012) Valerie Chew et al.   JNCI-Journal of the National Cancer Institute

Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein

(2012) Dharmendra Raghuwanshi et al.   MOLECULAR PHARMACEUTICS

A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of Chronic Fatigue Syndrome

(2012) David R. Strayer et al.   PLoS One

Intranasal Administration of dsRNA Analog Poly(I:C) Induces Interferon-α Receptor-Dependent Accumulation of Antigen Experienced T Cells in the Airways

(2012) Beth McNally et al.   PLoS One

Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses

(2012) J. Garaude et al.   Science Translational Medicine

Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor

(2012) Yoonkyung Do et al.   VACCINE

The impact of nanoparticle ligand density on dendritic-cell targeted vaccines

(2011) Arunima Bandyopadhyay et al.   BIOMATERIALS

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

(2011) P. J. Tacken et al.   BLOOD

Phase I Study Utilizing a Novel Antigen-Presenting Cell-Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

(2011) M. A. Morse et al.   CLINICAL CANCER RESEARCH

Particulate vaccines: on the quest for optimal delivery and immune response

(2011) Marie-Luce De Temmerman et al.   DRUG DISCOVERY TODAY

ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells

(2011) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trends in vaccine adjuvants

(2011) Virgil EJC Schijns et al.   Expert Review of Vaccines

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

(2011) Melissa Swiecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-Induced Transient Immune Suppression and the Inhibition of T Cell Proliferation by Type I Interferon

(2011) H. D. Marshall et al.   JOURNAL OF VIROLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

(2011) B. J. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors

(2011) Darin A. Wick et al.   VACCINE

The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system

(2011) Abbi L Engel et al.   Expert Review of Clinical Pharmacology

Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody

(2010) C. Cheong et al.   BLOOD

Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-α and IFN-γ dependent manners

(2010) Xinmei Zhu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

TLR signalling regulated antigen presentation in dendritic cells

(2010) Colin Watts et al.   CURRENT OPINION IN IMMUNOLOGY

New adjuvants for human vaccines

(2010) M Lamine Mbow et al.   CURRENT OPINION IN IMMUNOLOGY

Combination adjuvants: the next generation of adjuvants?

(2010) George Mutwiri et al.   Expert Review of Vaccines

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prophylactic, therapeutic and immune enhancement effect of liposome-encapsulated PolyICLC on highly pathogenic H5N1 influenza infection

(2010) Yi Li et al.   JOURNAL OF GENE MEDICINE

Type I IFN Substitutes for T Cell Help during Viral Infections

(2010) M. Wiesel et al.   JOURNAL OF IMMUNOLOGY

TLR3 and Rig-Like Receptor on Myeloid Dendritic Cells and Rig-Like Receptor on Human NK Cells Are Both Mandatory for Production of IFN-  in Response to Double-Stranded RNA

(2010) I. Perrot et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Polyinosinic:Polycytidylic Acid Boosts the Generation of Memory CD8 T Cells through Melanoma Differentiation-Associated Protein 5 Expressed in Stromal Cells

(2010) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus

(2010) Takeshi Ichinohe et al.   JOURNAL OF MEDICAL VIROLOGY

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

(2010) Xinmei Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma

(2010) M. R. Rosenfeld et al.   NEURO-ONCOLOGY

Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

(2010) Kavita Tewari et al.   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

Optimized Peptide Vaccines Eliciting Extensive CD8 T-Cell Responses with Therapeutic Antitumor Effects

(2009) H.-I. Cho et al.   CANCER RESEARCH

Toll-Like Receptor 3 Ligand and Retinoic Acid Enhance Germinal Center Formation and Increase the Tetanus Toxoid Vaccine Response

(2009) Y. Ma et al.   Clinical and Vaccine Immunology

Mechanism of action of clinically approved adjuvants

(2009) Bart N Lambrecht et al.   CURRENT OPINION IN IMMUNOLOGY

The ABC of clinical and experimental adjuvants—A brief overview

(2009) Richard Brunner et al.   IMMUNOLOGY LETTERS

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Not All Polyriboinosinic-polyribocytidylic Acids (Poly I:C) are Equivalent for Inducing Maturation of Dendritic Cells

(2009) Tony Avril et al.   JOURNAL OF IMMUNOTHERAPY

PolyI:polyC12U adjuvant-combined intranasal vaccine protects mice against highly pathogenic H5N1 influenza virus variants

(2009) Takeshi Ichinohe et al.   VACCINE

Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer

(2009) B. Jasani et al.   VACCINE

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

(2009) Christiane Stahl-Hennig et al.   PLoS Pathogens

Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells

(2009) Keiichi Kajiwara et al.   ALLERGOLOGY INTERNATIONAL

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

(2008) J. Mouries et al.   BLOOD

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages

(2008) Thornik Reimer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas

(2008) Nicholas Butowski et al.   JOURNAL OF NEURO-ONCOLOGY

A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05)

(2008) Nicholas Butowski et al.   JOURNAL OF NEURO-ONCOLOGY

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

(2008) Eva Schlosser et al.   VACCINE

A clinical grade poly I:C-analogue (Ampligen®) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro

(2008) H. Navabi et al.   VACCINE