Progress and hurdles in the development of vaccines against enterotoxigenicEscherichia coliin humans

Characterization of a Mutant Escherichia coli Heat-Labile Toxin, LT(R192G/L211A), as a Safe and Effective Oral Adjuvant

(2011) Elizabeth B. Norton et al.   Clinical and Vaccine Immunology

A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and Heat-Labile Toxin Subunit B Is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase I Trial in Healthy Adults

(2011) Clayton Harro et al.   Clinical and Vaccine Immunology

Generation and Characterization of a Live Attenuated Enterotoxigenic Escherichia coli Combination Vaccine Expressing Six Colonization Factors and Heat-Labile Toxin Subunit B

(2011) Arthur K. Turner et al.   Clinical and Vaccine Immunology

Outer Membrane Vesicles Induce Immune Responses to Virulence Proteins and Protect against Colonization by Enterotoxigenic Escherichia coli

(2011) Koushik Roy et al.   Clinical and Vaccine Immunology

Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines

(2011) Clayton Harro et al.   Clinical and Vaccine Immunology

Heat-Labile- and Heat-Stable-Toxoid Fusions (LTR192G-STaP13F) of Human Enterotoxigenic Escherichia coli Elicit Neutralizing Antitoxin Antibodies

(2011) Mei Liu et al.   INFECTION AND IMMUNITY

Expression of the cholera toxin B subunit (CT-B) in maize seeds and a combined mucosal treatment against cholera and traveler’s diarrhea

(2011) S. Karaman et al.   PLANT CELL REPORTS

Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants

(2011) Sergio Rosales-Mendoza et al.   PLANT CELL REPORTS

Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice

(2011) Joshua Tobias et al.   VACCINE

A systematic review of experimental infections with enterotoxigenic Escherichia coli (ETEC)

(2011) Chad K. Porter et al.   VACCINE

A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression

(2011) S.D. Isidean et al.   VACCINE

Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines

(2010) Joshua Tobias et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

(2010) Myron M Levine   BMC BIOLOGY

Genetic Fusions of Heat-Labile Toxoid (LT) and Heat-Stable Toxin b (STb) of Porcine Enterotoxigenic Escherichia coli Elicit Protective Anti-LT and Anti-STb Antibodies

(2010) W. Zhang et al.   Clinical and Vaccine Immunology

In plantaproduction of plant-derived and non-plant-derived adjuvants

(2010) Antonio Granell et al.   Expert Review of Vaccines

Heat-Stable Enterotoxin of Enterotoxigenic Escherichia coli as a Vaccine Target

(2010) A. Taxt et al.   INFECTION AND IMMUNITY

Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial

(2010) K Zaman et al.   LANCET

Global, regional, and national causes of child mortality in 2008: a systematic analysis

(2010) Robert E Black et al.   LANCET

Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

(2010) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Little Heterogeneity among Genes Encoding Heat-Labile and Heat-Stable Toxins of Enterotoxigenic Escherichia coli Strains Isolated from Diarrheal Pigs

(2009) C. Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genetic Fusions of Heat-Labile (LT) and Heat-Stable (ST) Toxoids of Porcine Enterotoxigenic Escherichia coli Elicit Neutralizing Anti-LT and Anti-STa antibodies

(2009) W. Zhang et al.   INFECTION AND IMMUNITY

Expression and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile Toxin B Subunit in Transgenic Rice Callus

(2009) Tae-Geum Kim et al.   MOLECULAR BIOTECHNOLOGY

Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model

(2009) Koushik Roy et al.   VACCINE

Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model

(2008) W. Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Randomized Clinical Trial Assessing the Safety and Immunogenicity of Oral Microencapsulated Enterotoxigenic Escherichia coli Surface Antigen 6 with or without Heat-Labile Enterotoxin with Mutation R192G

(2008) J. A. Lapa et al.   Clinical and Vaccine Immunology

The EtpA Exoprotein of Enterotoxigenic Escherichia coli Promotes Intestinal Colonization and Is a Protective Antigen in an Experimental Model of Murine Infection

(2008) K. Roy et al.   INFECTION AND IMMUNITY

Genetic Diversity of Heat-Labile Toxin Expressed by Enterotoxigenic Escherichia coli Strains Isolated from Humans

(2008) M. A. Lasaro et al.   JOURNAL OF BACTERIOLOGY

Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial

(2008) Sarah A Frech et al.   LANCET

Expression of anEscherichia coliantigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants

(2008) Sergio Rosales-Mendoza et al.   PLANT JOURNAL

A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enterotoxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC

(2008) Robin McKenzie et al.   VACCINE

Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriae

(2008) Joshua Tobias et al.   VACCINE

Preexisting antibodies to homologous colonization factors and heat-labile toxin in serum, and the risk to develop enterotoxigenic Escherichia coli-associated diarrhea

(2007) Joshua Tobias et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE