Article
Microbiology
Martin Peter Rydal, Claus Bottcher Jorgensen, Michela Gambino, Louise Ladefoged Poulsen, Jens Peter Nielsen
Summary: The study found an association between the CHCF1 genotype and susceptibility to ETEC F4ab in pigs. Pigs with the CHCF1 RS genotype were more likely to develop ETEC diarrhea compared to those with the CHCF1 RR genotype. The CHCF1 marker showed better accuracy in determining susceptibility to ETEC F4ab than other markers.
VETERINARY MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xi Lu, Dingyan Wu, Xin Zhao, Mingxin Zhang, Ke Ren, Ningning Zhou, Yanni Zhao, Weisheng Qian
Summary: Enterotoxigenic Escherichia coli (ETEC), a diarrheal pathogen, can utilize ethanolamine (EA) as a nitrogen source, which enhances its virulence phenotype and causes damage to host intestinal cells. The concentration of EA in the intestine also impacts the metabolic profile and pathogenicity of ETEC.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Weichun Xie, Liying Song, Xueying Wang, Yigang Xu, Zengsu Liu, Dongfang Zhao, Shubo Wang, Xiaolong Fan, Zhaorui Wang, Chong Gao, Xiaona Wang, Li Wang, Xinyuan Qiao, Han Zhou, Wen Cui, Yanping Jiang, Yijing Li, Lijie Tang
Summary: LR-LFCA can colonize the intestines of piglets, improve growth performance, enhance immune response, and benefit intestinal health by improving intestinal barrier function and modulating gut microbiota composition. LR-LFCA attenuated weight loss and diarrhea incidence in piglets infected with ETEC, by decreasing inflammation and oxidative stress, increasing tight junction proteins expression, and enhancing antioxidant capacity. LR-LFCA may activate MLCK and inhibit NF-kappa B pathways, providing a promising alternative therapeutic method for intestinal inflammation.
Article
Microbiology
Shan-Shan Peng, Yingjie Li, Qiuhong Chen, Qi Hu, Ying He, Lianqiang Che, Ping-Ping Jiang
Summary: This study investigated the changes in mucosal microbiome and protein expression in the ileum induced by ETEC infection using pigs as a model. The results showed that ETEC infection caused inflammation, impaired bile acid circulation, and the mucosal microbiome may affect the expression of intestinal proteins.
Article
Pharmacology & Pharmacy
Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin, as an alternative for antimicrobials, shows potential in preventing ETEC infections in pigs by reducing fluid secretion and colonization ability of ETEC.
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Chemistry, Applied
Jin Wan, Jiao Zhang, Qingsong Xu, Heng Yin, Daiwen Chen, Bing Yu, Jun He
Summary: The study demonstrates that alginate oligosaccharide can protect the intestinal mucosa from inflammatory injury induced by Escherichia coli and achieve this effect by inhibiting the activation of NF-kappa B.
CARBOHYDRATE POLYMERS
(2021)
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered porcine macrophage functions, including bacteriostatic and bactericidal activities, as well as reducing macrophage death caused by ETEC infection.
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered macrophage functions, enhancing bacterial clearance and reducing macrophage death. Melatonin may play a crucial role in shaping porcine macrophage function during ETEC infection.
Article
Immunology
Eric R. Hall, Aisling O'Dowd, Julianne E. Rollenhagen, Nereyda Espinoza, Gladys Nunez, Stephen J. Savarino
Summary: Enterotoxigenic Escherichia coli (ETEC) is a common cause of diarrheal illness, but lacks licensed vaccine and effective therapy. Researchers have developed ETEC infection models in Aotus nancymaae monkeys, which can help assess the efficacy of future vaccines and treatments.
INFECTION AND IMMUNITY
(2021)
Article
Agriculture, Dairy & Animal Science
Alberto Prieto, Cynthia Lopez-Novo, Pablo Diaz, Jose Manuel Diaz-Cao, Gonzalo Lopez-Lorenzo, Claudia Anton, Susana Remesar, David Garcia-Dios, Ceferino Lopez, Rosario Panadero, Pablo Diez-Banos, Patrocinio Morrondo, Gonzalo Fernandez
Summary: Neonatal calf diarrhoea is a significant issue in cattle production worldwide, with enterotoxigenic Escherichia coli (ETEC) being one of the major pathogens. Veterinary surgeons commonly use antimicrobials to treat the disease, but this study found that all ETEC strains were resistant to three or more families of antimicrobials. Only a few antibiotics showed efficacy against most ETEC strains, while many strains were resistant to first-line antimicrobials used in veterinary practice. The study emphasizes the importance of performing antimicrobial susceptibility tests in each outbreak to ensure effective treatment and prevent the emergence of new resistance mechanisms.
Article
Veterinary Sciences
Martin Peter Rydal, Michela Gambino, Claus Bottcher Jorgensen, Louise Ladefoged Poulsen, Lone Brondsted, Jens Peter Nielsen
Summary: Host genotype plays a crucial role in the susceptibility to enterotoxigenic E. coli (ETEC), with CHCF1 genotype possibly corresponding to susceptibility towards ETEC F4ac/ab infection.
BMC VETERINARY RESEARCH
(2022)
Article
Microbiology
Frederick Matthew Kuhlmann, Vadim Grigura, Timothy J. Vickers, Michael G. Prouty, Lora L. Iannotti, Sherlie Jean Louis Dulience, James M. Fleckenstein
Summary: Enterotoxigenic Escherichia coli (ETEC) is a common cause of infectious diarrhea in young children and travelers in low- and middle-income countries. This study compared immune responses to ETEC antigens in populations from endemic regions and sporadic infection regions, and found elevated immune responses in individuals from endemic regions. These findings support further evaluation of certain ETEC antigens as potential vaccine candidates.
Article
Multidisciplinary Sciences
Justin X. Boeckman, Sarah Sprayberry, Abby M. Korn, Jan S. Suchodolski, Chad Paulk, Kenneth Genovese, Raquel R. Rech, Paula R. Giaretta, Anna K. Blick, Todd Callaway, Jason J. Gill
Summary: Post-weaning enteropathies in swine caused by pathogenic E. coli, such as post-weaning diarrhea (PWD) or edema disease (ED), continue to be a significant concern for the swine industry. This study aimed to induce clinical signs of post-weaning disease in a piglet model using different doses of a pathogenic E. coli strain and evaluated various markers to monitor the disease state. The findings suggest that chronic dosing with a lower pathogen dose can mimic acute dosing, indicating that high pathogen doses may not be necessary for disease induction in the piglet model.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Gastroenterology & Hepatology
Mark S. Riddle, Chad K. Porter
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2018)
Editorial Material
Public, Environmental & Occupational Health
Mary T. Brueggemeyer, Mark Riddle, Arthur L. Kellermann
AMERICAN JOURNAL OF PUBLIC HEALTH
(2018)
Article
Infectious Diseases
Ibrahim A. Khalil, Christopher Troeger, Brigette F. Blacker, Puja C. Rao, Alexandria Brown, Deborah E. Atherly, Thomas G. Brewer, Cyril M. Engmann, Eric R. Houpt, Gagandeep Kang, Karen L. Kotloff, Myron M. Levine, Stephen P. Luby, Calman A. MacLennan, William K. Pan, Patricia B. Pavlinac, James A. Platts-Mills, Firdausi Qadri, Mark S. Riddle, Edward T. Ryan, David A. Shoultz, A. Duncan Steele, Judd L. Walson, John W. Sanders, Ali H. Mokdad, Christopher J. L. Murray, Simon I. Hay, Robert C. Reiner
LANCET INFECTIOUS DISEASES
(2018)
Article
Multidisciplinary Sciences
Tahaniyat Lalani, Michele D. Tisdale, Jie Liu, Indrani Mitra, Cliff Philip, Elizabeth Odundo, Faviola Reyes, Mark P. Simons, Jamie A. Fraser, Emma Hutley, Patrick Connor, Brett E. Swierczewski, Eric Houpt, David R. Tribble, Mark S. Riddle
Article
Pediatrics
Christopher Troeger, Ibrahim A. Khalil, Puja C. Rao, Shujin Cao, Brigette F. Blacker, Tahmeed Ahmed, George Armah, Julie E. Bines, Thomas G. Brewer, Danny Colombara, Gagandeep Kang, Beth D. Kirkpatrick, Carl D. Kirkwood, Jason M. Mwenda, Umesh D. Parashar, William A. Petri, Mark S. Riddle, A. Duncan Steele, Robert L. Thompson, Judd L. Walson, John W. Sanders, Ali H. Mokdad, Christopher J. L. Murray, Simon Hay, Robert C. Reiner
Review
Gastroenterology & Hepatology
Mark S. Riddle, Patrick Connor, Chad K. Porter
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
R. S. Choung, F. Petralia, J. Torres, T. Sato, X. -J. Li, P. Wang, S. Telesco, C. Porter, R. Laird, R. Gutierrez, F. Princen, S. Plevy, R. Strauss, M. Riddle, J. Murray, J. F. Colombel
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Immunology
Egle Butkeviciute, Holly J. Prudden, Mark Jit, Peter G. Smith, Gagandeep Kang, Mark S. Riddle, Benjamin A. Lopman, Virginia E. Pitzer, Claudio F. Lanata, James A. Platts-Mills, Robert F. Breiman, Birgitte K. Giersing, Mateusz Hasso-Agopsowicz
Summary: This study compared the quality of studies used by IHME and MCEE to estimate mortality associated with enterotoxigenic Escherichia coli and Shigella in 2016. The results showed that the majority of studies used by both modeling groups were of high quality, with an overrepresentation of studies from certain regions. Recommendations were made for future estimates of mortality associated with enteric diseases.
Article
Immunology
Ryan C. Johnson, Joy D. Van Nostrand, Michele Tisdale, Brett Swierczewski, Mark P. Simons, Patrick Connor, Jamie Fraser, Angela R. Melton-Celsa, David R. Tribble, Mark S. Riddle
Summary: The study found that single-dose antibiotic regimens may not significantly alter the functional or antibiotic resistance composition of fecal microflora, which should inform clinical practice guidelines and antimicrobial stewardship.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Mark S. Riddle, A. Louis Bourgeois, Allison Clifford, Suhi Jeon, Birgitte K. Giersing, Mark Jit, Marta Tufet Bayona, Jared Ovitt, William P. Hausdorff
Summary: Shigella, a gram-negative bacterium, is a major cause of severe diarrhea and dysentery in children under five in low- and middle-income countries. Despite the development of promising Shigella vaccine candidates, the recommendation and adoption of such vaccines may face challenges due to declining disease rates, complex immunization programs, and availability of other vaccines.
Editorial Material
Public, Environmental & Occupational Health
Mark S. Riddle, Charles D. Ericsson, Robert Steffen
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Immunology
Christopher Duplessis, Kristen A. Clarkson, K. Ross Turbyfill, Ashley N. Alcala, Ramiro Gutierrez, Mark S. Riddle, Tida Lee, Kristopher Paolino, Hailey P. Weerts, Amanda Lynen, Edwin Oaks, Chad K. Porter, Robert Kaminski
Summary: Shigella species cause severe disease and an effective vaccine is urgently needed. InvaplexAR vaccine, a subunit vaccine approach, demonstrated increased immunogenicity in pre-clinical studies and was tested in a phase 1 trial, showing safety and potential for inducing immune responses.
Letter
Public, Environmental & Occupational Health
Mark S. Riddle, Bradley A. Connor, Robert Steffen, Phyllis Kozarsky, Charles D. Ericsson
JOURNAL OF TRAVEL MEDICINE
(2018)
Article
Immunology
Joanna E. Rimmer, Clayton Harro, David A. Sack, Kawsar R. Talaat, Ramiro L. Gutierrez, Barbara DeNearing, Jessica Brubaker, Renee M. Laird, Frederic Poly, Alexander C. Maue, Kayla Jaep, Ashley Alcala, Yelizaveta Mochalova, Christina L. Gariepy, Subhra Chakraborty, Patricia Guerry, David R. Tribble, Chad K. Porter, Mark S. Riddle
CLINICAL INFECTIOUS DISEASES
(2018)
Review
Medicine, General & Internal
Mark S. Riddle
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2018)