Chemistry-based functional proteomics for drug target deconvolution

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP

(2011) Evelyn Zeiler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical kinomics: a powerful strategy for target deconvolution

(2011) Do-Hee Kim et al.   BMB Reports

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

(2011) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

(2011) Peng-Yu Yang et al.   CHEMICAL COMMUNICATIONS

Activity-Based Profiling for Drug Discovery

(2011) Remigiusz Serwa et al.   CHEMISTRY & BIOLOGY

A Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis

(2011) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Drug target deconvolution by chemical proteomics

(2011) Manfred Raida   CURRENT OPINION IN CHEMICAL BIOLOGY

Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection

(2011) Na Xie et al.   Journal of Proteomics

Multicolor, One- and Two-Photon Imaging of Enzymatic Activities in Live Cells with Fluorescently Quenched Activity-Based Probes (qABPs)

(2011) Mingyu Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Activity-based protein profiling of host–virus interactions

(2011) David R. Blais et al.   TRENDS IN BIOTECHNOLOGY

Activity-based probes: discovering new biology and new drug targets

(2010) William P. Heal et al.   CHEMICAL SOCIETY REVIEWS

Application of Chemistry-Based Functional Proteomics to Screening for Novel Drug Targets

(2010) Kefei Yuan et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Integrative oncoproteomics strategies for anticancer drug discovery

(2010) Rui Liu et al.   Expert Review of Proteomics

Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication

(2010) David R. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Identification of Binding Partners for the Brain Metabolite Lanthionine Ketimine (LK) and Documentation of LK Effects on Microglia and Motoneuron Cell Cultures

(2010) K. Hensley et al.   JOURNAL OF NEUROSCIENCE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe

(2010) Ragunath Singaravelu et al.   Proteome Science

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites

(2009) Kai Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase

(2009) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Development and application of high-performance affinity beads: Toward chemical biology and drug discovery

(2009) Satoshi Sakamoto et al.   CHEMICAL RECORD

Drug Discovery and Protein Tyrosine Phosphatases

(2009) Mark Blaskovich   CURRENT MEDICINAL CHEMISTRY

Profiling protein tyrosine phosphatase activity with mechanistic probes

(2009) Divya Krishnamurthy et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New screens and targets in antibacterial drug discovery

(2009) Shannon B Falconer et al.   CURRENT OPINION IN MICROBIOLOGY

Revealing promiscuous drug–target interactions by chemical proteomics

(2009) Marcus Bantscheff et al.   DRUG DISCOVERY TODAY

Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution

(2009) Chaitanya Saxena et al.   Expert Opinion on Drug Discovery

Quantitative proteomics and biomarker discovery in human cancer

(2009) Yingchun Zhao et al.   Expert Review of Proteomics

Advanced proteomic technologies for cancer biomarker discovery

(2009) Sze Chuen Cesar Wong et al.   Expert Review of Proteomics

Capture of Drug Targets from Live Cells Using a Multipurpose Immuno-Chemo-Proteomics Tool

(2009) Chaitanya Saxena et al.   JOURNAL OF PROTEOME RESEARCH

Activity-Based Proteome Profiling of Hepatoma Cells during Hepatitis C Virus Replication Using Protease Substrate Probes

(2009) David R. Blais et al.   JOURNAL OF PROTEOME RESEARCH

β-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA

(2009) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selectivity in Enrichment of cAMP-dependent Protein Kinase Regulatory Subunits Type I and Type II and Their Interactors Using Modified cAMP Affinity Resins

(2009) Thin Thin Aye et al.   MOLECULAR & CELLULAR PROTEOMICS

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia

(2009) D. J. Shields et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

(2009) Jenny J. Fischer et al.   TOXICOLOGICAL SCIENCES

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Comparative plasma membrane-associated proteomics of immortalized human hepatocytes

(2008) Lan-Tu Gou et al.   BIOCHEMISTRY-MOSCOW

Activity-Based Protein Profiling: New Developments and Directions in Functional Proteomics

(2008) Mahesh Uttamchandani et al.   CHEMBIOCHEM

Proteomic methods for drug target discovery

(2008) Lekha Sleno et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Application of activity-based probes to the study of enzymes involved in cancer progression

(2008) Margot G Paulick et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Proteomics: Advances in Biomarker Discovery

(2008) Matthew L Cowan et al.   Expert Review of Proteomics

Activity-based probes as a tool for functional proteomic analysis of proteases

(2008) Marko Fonović et al.   Expert Review of Proteomics

An Immuno-Chemo-Proteomics Method for Drug Target Deconvolution

(2008) Chaitanya Saxena et al.   JOURNAL OF PROTEOME RESEARCH

Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes

(2008) Cleo M. Salisbury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

(2008) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

(2008) L L Remsing Rix et al.   LEUKEMIA

Metadegradomics

(2008) Alain Doucet et al.   MOLECULAR & CELLULAR PROTEOMICS

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

Targeted proteomic strategy for clinical biomarker discovery

(2008) Ralph Schiess et al.   Molecular Oncology

β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana

(2008) Zheming Wang et al.   Nature Chemical Biology