Activity-based probes: discovering new biology and new drug targets

Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting CellsviaMannose Receptors

(2010) Eun-Ang Raiber et al.   ACS Chemical Biology

Chemical Probes of Surface Layer Biogenesis inClostridium difficile

(2010) T. H. Tam Dang et al.   ACS Chemical Biology

Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry

(2010) Alexandra F. H. Berry et al.   CHEMBIOCHEM

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

(2010) Sungwook Choi et al.   Nature Chemical Biology

The use of click chemistry in the emerging field of catalomics

(2010) Karunakaran A. Kalesh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Finding enzymes that are actively involved in cancer

(2010) M. Bogyo   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next Generation Chemical Proteomic Tools for Rapid Enzyme Profiling

(2009) Mahesh Uttamchandani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery

(2009) Kerry Routenberg Love et al.   ACS Chemical Biology

Using Small Molecules To Dissect Mechanisms of Microbial Pathogenesis

(2009) Aaron W. Puri et al.   ACS Chemical Biology

An Orthogonal Active Site Identification System (OASIS) for Proteomic Profiling of Natural Product Biosynthesis

(2009) Jordan L. Meier et al.   ACS Chemical Biology

Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells

(2009) Ulrik Hillaert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay

(2009) Chun-Chen Kuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases

(2009) Kui Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activity-Based Probes for Monitoring Postproline Protease Activity

(2009) Eduard Sabidó et al.   CHEMBIOCHEM

Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase

(2009) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Small molecule probes that target Ablkinase

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs)

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

Expanding the Chemical Biologists Tool Kit: Chemical Labelling Strategies and Its Applications

(2009) Souvik Chattopadhaya et al.   CURRENT MEDICINAL CHEMISTRY

Model systems: how chemical biologists study RNA

(2009) Andro C Rios et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cwp84, a Surface-associated Cysteine Protease, Plays a Role in the Maturation of the Surface Layer of Clostridium difficile

(2009) Jonathan M. Kirby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes

(2009) Martin D. Witte et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells

(2009) Hong Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes

(2009) Aaron T. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA

(2009) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin

(2009) Aimee Shen et al.   Nature Chemical Biology

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

Getting a chemical handle on proteinpost-translational modification

(2009) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

(2009) Christian Gu et al.   PLANT JOURNAL

Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity

(2009) Galia Blum et al.   PLoS One

4-Bromophenacyl Bromide Specifically Inhibits Rhoptry Secretion during Toxoplasma Invasion

(2009) Sandeep Ravindran et al.   PLoS One

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

(2008) C Adams et al.   CELL DEATH AND DIFFERENTIATION

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

An Activity-Based Protein Profiling Probe for the Nicotinic Acetylcholine Receptor

(2008) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clostridium difficile infection

(2008) Ernst J Kuipers et al.   LANCET

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

N-Myristoyl transferase-mediated protein labelling in vivo

(2008) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selective Activity-Based Probes for Cysteine Cathepsins

(2007) Anja Watzke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry

(2007) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification ofPseudomonas aeruginosaNagZ

(2007) Keith A. Stubbs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY