Clinical trials in cellular immunotherapy for brain/CNS tumors

Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial

(2012) Hilko Ardon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma

(2012) Surasak Phuphanich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein

(2012) C. A. Crane et al.   CLINICAL CANCER RESEARCH

Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination

(2012) Fabian Benencia et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Interdisciplinary Critique of Sipuleucel-T as Immunotherapy in Castration-Resistant Prostate Cancer

(2012) M. L. Huber et al.   JNCI-Journal of the National Cancer Institute

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

(2012) Mark S Pearce et al.   LANCET

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

Trials and Tribulations of Cancer Immunotherapy

(2012) Demirkan B. Gürsel et al.   NEUROSURGERY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoimmunity associated with immunotherapy of cancer

(2011) S. M. Amos et al.   BLOOD

Cancer Immunotherapy

(2011) Robert O. Dillman   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Clinical Application of a Dendritic Cell Vaccine Raised Against Heat-Shocked Glioblastoma

(2011) X. Jie et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype

(2011) K. Dziurzynski et al.   CLINICAL CANCER RESEARCH

Is Cytomegalovirus a Therapeutic Target in Glioblastoma?

(2011) J. H. Sampson et al.   CLINICAL CANCER RESEARCH

Do we need novel radiologic response criteria for brain tumor immunotherapy?

(2011) Hideho Okada et al.   Expert Review of Neurotherapeutics

A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy

(2011) Priyadharshini Narayanan et al.   JOURNAL OF CLINICAL INVESTIGATION

A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma

(2011) Chen-Nen Chang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Immune Response in Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Intranodal Autologous Tumor Lysate-dendritic Cell Vaccination After Radiation Chemotherapy

(2011) Camilo E. Fadul et al.   JOURNAL OF IMMUNOTHERAPY

HLA homozygosity and haplotype bias among patients with chronic lymphocytic leukemia: implications for disease control by physiological immune surveillance

(2011) N Shah et al.   LEUKEMIA

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial

(2011) Der-Yang Cho et al.   World Neurosurgery

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

(2010) N. Ahmed et al.   CLINICAL CANCER RESEARCH

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas

(2010) Anne Clavreul et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Trial of a Personalized Peptide Vaccine for Patients Positive for Human Leukocyte Antigen–A24 With Recurrent or Progressive Glioblastoma Multiforme

(2010) Mizuhiko Terasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study

(2010) Hilko Ardon et al.   JOURNAL OF NEURO-ONCOLOGY

Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone

(2010) Michael P. Gustafson et al.   NEURO-ONCOLOGY

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

(2010) J. H. Sampson et al.   NEURO-ONCOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intralesional Lymphokine-activated Killer Cells as Adjuvant Therapy for Primary Glioblastoma

(2009) Robert Owen Dillman et al.   JOURNAL OF IMMUNOTHERAPY

Genetically engineered T cells to target EGFRvIII expressing glioblastoma

(2009) Szofia S. Bullain et al.   JOURNAL OF NEURO-ONCOLOGY

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

(2009) J. H. Sampson et al.   MOLECULAR CANCER THERAPEUTICS

Detection of human cytomegalovirus in different histological types of gliomas

(2008) Michael E. Scheurer et al.   ACTA NEUROPATHOLOGICA

Vaccination Elicits Correlated Immune and Clinical Responses in Glioblastoma Multiforme Patients

(2008) C. J. Wheeler et al.   CANCER RESEARCH

Postoperative Adjuvant Dendritic Cell-Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme

(2008) S. De Vleeschouwer et al.   CLINICAL CANCER RESEARCH

Adjuvant dibromodulcitol and BCNU chemotherapy in anaplastic astrocytoma: Results of a randomised European Organisation for Research and Treatment of Cancer phase III study (EORTC study 26882)

(2008) Jerzy Hildebrand et al.   EUROPEAN JOURNAL OF CANCER

Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme

(2008) Shuichi Izumoto et al.   JOURNAL OF NEUROSURGERY

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

(2008) Joannes F.M. Jacobs et al.   NEURO-ONCOLOGY

GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME

(2008) Nader Sanai et al.   NEUROSURGERY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy

(2007) David G. Walker et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma

(2007) Duane A. Mitchell et al.   NEURO-ONCOLOGY