Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination

Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations

(2014) C. Jakubzick et al.   JOURNAL OF IMMUNOLOGY

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

(2011) R. van de Ven et al.   BLOOD

The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells

(2011) Leslee Sprague et al.   BMC IMMUNOLOGY

Dendritic cell-directed lentivector vaccine induces antigen-specific immune responses against murine melanoma

(2011) H G Yang et al.   CANCER GENE THERAPY

CpG-conjugated apoptotic tumor cells elicit potent tumor-specific immunity

(2011) Hidekazu Shirota et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer

(2011) Qiushan He et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

(2011) Christina S. Chu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes

(2011) Else M. Inderberg Suso et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cells adenovirally-transduced with full-length mesothelin cDNA elicit mesothelin-specific cytotoxicity against pancreatic cancer cell lines in vitro

(2011) Motoki Miyazawa et al.   CANCER LETTERS

Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model

(2011) T C Felizardo et al.   GENE THERAPY

VEGF-A not Ang2 mediates endothelial-like differentiation of immature DCs by ERK1/2 signaling in the microenvironment of human colon adenocarcinoma

(2011) Ziming Dong   INTERNATIONAL JOURNAL OF ONCOLOGY

Lentivirally engineered dendritic cells activate AFP-specific T cells which inhibit hepatocellular carcinoma growth in vitro and in vivo

(2011) Yang Liu   INTERNATIONAL JOURNAL OF ONCOLOGY

Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8 + Type

(2011) K. Crozat et al.   JOURNAL OF IMMUNOLOGY

Cotransfection of Poly(I

(2011) Yasuharu Akasaki et al.   JOURNAL OF IMMUNOTHERAPY

Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy

(2011) Wenxue Ma et al.   Journal of Translational Medicine

Integrated Safety Data From 4 Randomized, Double-Blind, Controlled Trials of Autologous Cellular Immunotherapy With Sipuleucel-T in Patients With Prostate Cancer

(2011) Simon J. Hall et al.   JOURNAL OF UROLOGY

TNF  Accelerates Monocyte to Endothelial Transdifferentiation in Tumors by the Induction of Integrin  5 Expression and Adhesion to Fibronectin

(2011) B. Li et al.   MOLECULAR CANCER RESEARCH

Optimizing DC Vaccination by Combination With Oncolytic Adenovirus Coexpressing IL-12 and GM-CSF

(2011) Song-Nan Zhang et al.   MOLECULAR THERAPY

Tumour-loaded α-type 1-polarized Dendritic Cells from Patients with Chronic Lymphocytic Leukaemia Produce a Superior NK-, NKT- and CD8+ T Cell-attracting Chemokine Profile

(2011) Karin Gustafsson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Sipuleucel-T: Prototype for Development of Anti-tumor Vaccines

(2011) Estrella Carballido et al.   Current Oncology Reports

Dendritic cells transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes against ovarian cancer in vitro

(2010) Li Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma

(2010) J. Rosenblatt et al.   BLOOD

Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation

(2010) Fabian Benencia et al.   CANCER BIOLOGY & THERAPY

Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery

(2010) Gregory Driessens et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation

(2010) Willemijn van den Ancker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma

(2010) Jing Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

(2010) Patricia R. Taylor et al.   CELLULAR IMMUNOLOGY

A Randomized Trial of Ex vivo CD40L Activation of a Dendritic Cell Vaccine in Colorectal Cancer Patients: Tumor-Specific Immune Responses Are Associated with Improved Survival

(2010) R. J. Barth et al.   CLINICAL CANCER RESEARCH

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

(2010) J. F. M. Jacobs et al.   CLINICAL CANCER RESEARCH

The CD8+dendritic cell subset

(2010) Ken Shortman et al.   IMMUNOLOGICAL REVIEWS

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Dendritic Cell Population Generated by a Fusion of GM-CSF and IL-21 Induces Tumor-Antigen-Specific Immunity

(2010) P. Williams et al.   JOURNAL OF IMMUNOLOGY

CD11chi Dendritic Cells Regulate the Re-establishment of Vascular Quiescence and Stabilization after Immune Stimulation of Lymph Nodes

(2010) T. C. Tzeng et al.   JOURNAL OF IMMUNOLOGY

Antigen-Containing Liposomes Engrafted with Flagellin-Related Peptides Are Effective Vaccines That Can Induce Potent Antitumor Immunity and Immunotherapeutic Effect

(2010) A. Faham et al.   JOURNAL OF IMMUNOLOGY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type-1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8+ T cells against prostate cancer cells and defined prostate cancer-specific epitopes

(2010) Eva Wieckowski et al.   PROSTATE

Dendritic cell/tumor hybrids enhances therapeutic efficacy against colorectal cancer liver metastasis in SCID mice

(2010) Feng Xu et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

A large number of mature and functional dendritic cells can be efficiently generated from umbilical cord blood-derived mononuclear cells by a simple two-step culture method

(2010) Sreekumar Balan et al.   TRANSFUSION

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity

(2010) Biliang Hu et al.   VACCINE

J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells

(2010) P.R. Taylor et al.   VACCINE

The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC-205/CD205 Receptor on Dendritic Cells

(2009) Bei Wang et al.   Annals of the New York Academy of Sciences

Dramatic efficacy improvement of a DC-based vaccine against AML by CD25 T cell depletion allowing the induction of a long-lasting T cell response

(2009) Stéphanie Delluc et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeted Delivery of Tumor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice

(2009) H. Wei et al.   CLINICAL CANCER RESEARCH

Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial

(2009) Ann Van Driessche et al.   CYTOTHERAPY

Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells

(2009) Ofer Fainaru et al.   FASEB JOURNAL

Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity

(2009) Juan R. Cubillos-Ruiz et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Educated CD11b high Ia low Regulatory Dendritic Cells Suppress T Cell Response through Arginase I

(2009) Qiuyan Liu et al.   JOURNAL OF IMMUNOLOGY

IFN-producing Killer Dendritic Cells Contribute to the Inhibitory Effect of Poly I:C on the Progression of Murine Melanoma

(2009) Qun Jiang et al.   JOURNAL OF IMMUNOTHERAPY

Optimization of Dendritic Cell Loading With Tumor Cell Lysates for Cancer Immunotherapy

(2009) Paul Hatfield et al.   JOURNAL OF IMMUNOTHERAPY

Synergistic Effect of Dendritic Cell Vaccination and Anti-CD20 Antibody Treatment in the Therapy of Murine Lymphoma

(2009) Zohar Gadri et al.   JOURNAL OF IMMUNOTHERAPY

Evaluation of 3 Clinical Dendritic Cell Maturation Protocols Containing Lipopolysaccharide and Interferon-γ

(2009) Tae Hee Han et al.   JOURNAL OF IMMUNOTHERAPY

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

(2009) Hideki Nakano et al.   NATURE IMMUNOLOGY

DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma

(2009) Wim Maes et al.   NEURO-ONCOLOGY

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

(2009) K. Nagao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of CTL-associated Antigen-4 Blockade and Depletion of CD25+Regulatory T Cells Enhance Tumour Immunity of Dendritic Cell-based Vaccine in a Mouse Model of Colon Cancer

(2009) Asim Saha et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Paracrine Role of Tie-2-Expressing Monocytes in Tumor Angiogenesis

(2009) Domenico Ribatti   STEM CELLS AND DEVELOPMENT

Targeting anti-tumor DNA vaccines to dendritic cells via a short CD11c promoter sequence

(2009) Jing Ni et al.   VACCINE

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis

(2008) H. Chen et al.   BLOOD

Mechanisms of murine dendritic cell antitumor dysfunction in aging

(2008) Annabelle Grolleau-Julius et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity

(2008) Shinjiro Yamaguchi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High frequency of immature dendritic cells and altered in situ production of interleukin-4 and tumor necrosis factor-α in lung cancer

(2008) R. B. Baleeiro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity

(2008) E. Huarte et al.   CANCER RESEARCH

Killer Dendritic Cells Link Innate and Adaptive Immunity against Established Osteosarcoma in Rats

(2008) C. Chauvin et al.   CANCER RESEARCH

Recruitment and Activation of Natural Killer Cells In vitro by a Human Dendritic Cell Vaccine

(2008) K. Gustafsson et al.   CANCER RESEARCH

Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation

(2008) R. Muthuswamy et al.   CANCER RESEARCH

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

Human mature endothelial cells modulate peripheral blood mononuclear cell differentiation toward an endothelial phenotype

(2008) Lydia Bellik et al.   EXPERIMENTAL CELL RESEARCH

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Clinical Grade OK432-activated Dendritic Cells

(2008) Emma West et al.   JOURNAL OF IMMUNOTHERAPY

Whole tumor antigen vaccination using dendritic cells: Comparison of RNA electroporation and pulsing with UV-irradiated tumor cells

(2008) Fabian Benencia et al.   Journal of Translational Medicine

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

(2008) Claudia Waskow et al.   NATURE IMMUNOLOGY

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

Comparison of α-Type-1 polarizing and standard dendritic cell cytokine cocktail for maturation of therapeutic monocyte-derived dendritic cell preparations from cancer patients

(2008) Redas Trepiakas et al.   VACCINE

Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity

(2008) Davide Brusa et al.   VACCINE

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY

Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis

(2007) Ofer Fainaru et al.   FASEB JOURNAL

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE