Article
Oncology
Markus Y. Wu, Eric W. Zhang, Matthew R. Strickland, Dexter P. Mendoza, Lev Lipkin, Jochen K. Lennerz, Justin F. Gainor, Rebecca S. Heist, Subba R. Digumarthy
Summary: KRAS G12C mutations in lung cancer are important oncogenic mutations that exhibit distinct primary tumor imaging features and patterns of metastasis compared to lung cancers driven by other genetic alterations. These unique imaging features may provide clues to the presence of KRAS G12C NSCLC and potentially guide management strategies in the future.
Article
Immunology
Bo Zhang, Jingtong Zeng, Hao Zhang, Shuai Zhu, Hanqing Wang, Jinling He, Lingqi Yang, Ning Zhou, Lingling Zu, Xiaohong Xu, Zuoqing Song, Song Xu
Summary: The tumor microenvironment in ALK-rearranged NSCLC patients is characterized by immunosuppression compared to EGFR/KRAS-positive NSCLC. High expression of PD-L1 and CTLA4 is associated with lower survival rates in ALK-rearranged NSCLC patients treated with ALK-TKIs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Eabha O'Sullivan, Anna Keogh, Brian Henderson, Stephen P. Finn, Steven G. Gray, Kathy Gately
Summary: KRAS plays a crucial role in regulating cell growth and survival, and its activation is commonly observed in various types of tumors. Recent discoveries have identified a specific pocket in the structure of KRAS, leading to the development of inhibitors that target the G12C mutation. These inhibitors, such as sotorasib and adagrasib, have been approved for the treatment of non-small-cell lung cancer, but their efficacy may be limited by resistance mechanisms in cancer cells.
Article
Oncology
Feiwen Liu, Fang Wang, Jianbo He, Shaozhang Zhou, Min Luo
Summary: This study aimed to investigate the association between mutant KRAS and the risk of disease progression and death in advanced NSCLC. The results showed that KRAS mutation and KRAS non-G12C were prognostic factors for OS, but not for PFS. Combination therapy of chemotherapy with antiangiogenesis or immunotherapy was associated with decreased risk of disease progression in KRAS mutation patients compared to single chemotherapy.
Article
Biochemistry & Molecular Biology
Kirti Sad, Palak Parashar, Pragya Tripathi, Hungharla Hungyo, Ramesh Sistla, Ravi Soni, Vibha Tandon
Summary: Researchers discovered that the antipsychotic drug prochlorperazine (PCZ) can bind to KRAS mutant proteins and enhance the sensitivity of radiotherapy for non-small cell lung cancer cells, leading to cell cycle arrest by activating p-ATM, p53, and p21 proteins. PCZ combined with radiation decreased clonogenic survival of KRAS mutant cells but not KRAS-WT cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yang Fu, Yue Zheng, Pei-Pei Wang, Yue-Yun Chen, Zhen-Yu Ding
Summary: The predictive role of POLE mutations for immunotherapy is currently being investigated, and it is associated with other favorable predictive factors. There is a lack of clinical trials studying the efficacy of immunotherapy in lung cancer patients with POLE mutations, and lung cancer patients with brain metastasis are unresponsive to chemotherapy. A case report was presented, demonstrating the benefit of immune-combined therapy for advanced NSCLC patients with POLE mutation and brain metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, Xue-Qing Zhang
Summary: A noninvasive aerosol inhalation nanoparticle system has been developed for the treatment of KRAS-mutant non-small-cell lung cancer (NSCLC). The inhalable nanoparticles show effective tumor targeting and enhanced antitumor activity in a mouse model. Compared to systemic delivery, the nebulized nanoparticles demonstrate better biosafety and present a promising gene therapy approach for KRAS-mutant NSCLC and other respiratory diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Cheng-Yao Chiang, Songqing Fan, Hongmei Zheng, Wenjun Guo, Zehan Zheng, Yihua Sun, Chuanqi Zhong, Juan Zeng, Shuaihu Li, Min Zhang, Tian Xiao, Duo Zheng
Summary: This study reveals the tumor-suppressive role of SETD7 in non-small cell lung cancer (NSCLC) by modulating KRAS methylation and degradation. SETD7 interacts with KRAS and methylates KRAS at lysines 182 and 184, leading to KRAS degradation and attenuation of the RAS/MEK/ERK signaling cascade.
Article
Oncology
Yanxia Liu, Yuan Gao, Ying Wang, Cong Zhao, Zhiyun Zhang, Baolan Li, Tongmei Zhang
Summary: For first-line treatment of KRAS mutant NSCLC patients, immunotherapy, antiangiogenic therapy, and pemetrexed-based regimen provide more benefits. Subgroup analysis revealed the benefits of immunotherapy compared to chemotherapy were applicable in PD-L1 expression >= 1% subgroup, and antiangiogenic therapy could benefit non-G12C KRAS subgroup. Platinum-pemetrexed combined with antiangiogenic therapy may be the preferred chemotherapy regimen.
Article
Oncology
Shinichiro Suzuki, Kimio Yonesaka, Takeshi Teramura, Toshiyuki Takehara, Ryoji Kato, Hitomi Sakai, Koji Haratani, Junko Tanizaki, Hisato Kawakami, Hidetoshi Hayashi, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa
Summary: The study identified MET amplification as a mechanism of resistance to KRAS(G12C) inhibitors in NSCLC. Using MET inhibitor Crizotinib restored sensitivity to sotorasib, and dual inhibition of MET and KRAS(G12C) led to tumor shrinkage in sotorasib-resistant xenograft mice.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Lan-Lan Pang, Jia-Di Gan, Jia-Rong Tan, Yi-Hua Huang, Jun Liao, Wei-Ting Liang, Peng-Bo Deng, Wen-Feng Fang
Summary: This study revealed the differential benefits of afatinib in NSCLC patients with different mutation genotypes and identified potential resistance mechanisms in patients with EGFR G719X/L861Q/S768I for the first time. The findings have practical implications for guiding optimal treatment in clinical practice.
Article
Oncology
Milena Pazik, Katarzyna Michalska, Marta Zebrowska-Nawrocka, Izabela Zawadzka, Mariusz Lochowski, Ewa Balcerczak
Summary: This study found that increased relative HRAS mRNA level in blood was more frequent in smokers among non-small-cell lung cancer patients. Patients with squamous cell carcinoma subtypes were more likely to show overexpression of HRAS gene in blood. Overexpression of HRAS gene in tumor tissue was associated with adenocarcinoma subtype.
Article
Medicine, General & Internal
Oliver Illini, Hannah Fabikan, Maximilian Johannes Hochmair, Christoph Weinlinger, Dagmar Krenbek, Luka Brcic, Ulrike Setinek, Angelika Terbuch, Gudrun Absenger, Selma Konjic, Arschang Valipour
Summary: This study retrospectively assessed the clinicopathological features and standard-of-care treatment responses in patients with KRAS(G12C)-mutated advanced non-small cell lung cancer. The study highlights the poor outcomes in this patient population and emphasizes the need for new treatment options and specific molecular testing.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nguyen Quoc Khanh Le, Quang Hien Kha, Van Hiep Nguyen, Yung-Chieh Chen, Sho-Jen Cheng, Cheng-Yu Chen
Summary: The study introduced a machine learning model for selecting and predicting EGFR and KRAS mutations in NSCLC patients using a minimal number of semantic radiomics features, with the genetic algorithm plus XGBoost classifier showing the best accuracy in detecting these mutations. This noninvasive machine learning-based model demonstrated robust prediction of EGFR and KRAS mutations in patients with NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Atish Mohanty, Arin Nam, Saumya Srivastava, Jeff Jones, Brett Lomenick, Sharad S. Singhal, Linlin Guo, Hyejin Cho, Aimin Li, Amita Behal, Tamara Mirzapoiazova, Erminia Massarelli, Marianna Koczywas, Leonidas D. Arvanitis, Tonya Walser, Victoria Villaflor, Stanley Hamilton, Isa Mambetsariev, Martin Sattler, Mohd W. Nasser, Maneesh Jain, Surinder K. Batra, Raffaella Soldi, Sunil Sharma, Marwan Fakih, Saswat Kumar Mohanty, Avijit Mainan, Xiwei Wu, Yihong Chen, Yanan He, Tsui-Fen Chou, Susmita Roy, John Orban, Prakash Kulkarni, Ravi Salgia
Summary: This study reveals non-genetic mechanisms of resistance to sotorasib and proposes a treatment strategy to enhance sensitivity by targeting both ITGB4 and beta-catenin.
Article
Environmental Sciences
Zheng Li, Zhenghui Fu, Shuhang Wang, Yang Zhang, Jinbo Zhang, Yanxiao Liu, Huaicheng Guo, Pingjian Yang
Summary: This study conducted an ecological and human health risk assessment of metals and heavy metals in Qinghai Lake, the largest inland saltwater lake in China. The concentration, distribution, and source of these metals were investigated. It was found that the metals in the sediments of Qinghai Lake mainly came from five rivers entering the lake, with copper and zinc showing the highest enrichment capacity. The results of the risk assessment indicated low ecological risks and no threat to human health from the heavy metals in the lake's sediments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Oncology
Ning Jiang, Yue Yu, Dawei Wu, Shuhang Wang, Yuan Fang, Huilei Miao, Peiwen Ma, Huiyao Huang, Min Zhang, Yu Zhang, Yu Tang, Ning Li
Summary: This review provides a current understanding of the role of HLAs in cancer immunology. It summarizes how HLA alterations contribute to immune escape and resistance to immunotherapy, and potential methods to overcome HLA defects. The review also discusses the potential association between HLA and immune-related adverse events (irAEs). Downregulation, loss of heterogeneity, and entire loss of HLAs are responsible for immune escape. Overcoming HLA defects can be effective in cancer therapy. Non-classical HLA-I molecules, such as HLA-E and HLA-G, are reliable predictors of prognosis, while classical HLA-I expression is a potential predictor of favorable immunotherapy response. Certain HLA types may be associated with enhanced affinity to self-antigen-mimicked tumor antigens, which may positively correlate with irAEs triggered by checkpoint inhibitors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu, Yan-Fen Chai
Summary: There is an abnormal activation of the renin angiotensin aldosterone system (RAAS) in patients with Sepsis-Induced Cardiomyopathy (SIC). This study measured the protein concentrations of angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) in peripheral plasma collected from SIC patients and healthy controls, and explored the relationship between SIC, Ang II, and Ang-(1-7) levels. It was found that SIC patients had elevated Ang II and Ang II/Ang-(1-7) levels, while the healthy controls had higher Ang-(1-7) levels. Additionally, exogenous Ang-(1-7) showed protective effects against SIC by inhibiting inflammatory and oxidative stress pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Zhongyao Liang, Yaoyang Xu, Gang Zhao, Wentao Lu, Zhenghui Fu, Shuhang Wang, Tyler Wagner
Summary: This study proposes a novel framework using quantile regression and interpretable machine learning to identify factors forcing ecological observations to approach the upper boundary and explores its implications for ecosystem management.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Water Resources
Chi Xu, Wanchang Zhang, Shuhang Wang, Hao Chen, Abdullah Azzam, Bo Zhang, Yongxin Xu, Ning Nie
Summary: This study aimed to quantify the effects of climate change and land-use/land-cover dynamics on green water in the Sanjiang Plain. The results showed that after 2000, green water flow and storage in the region significantly increased. Climate change, particularly precipitation variations, accounted for over 56% of the changes in green water storage, while land-use changes, especially cropland transformation, contributed over 20% to the changes in green water flow.
JOURNAL OF HYDROLOGY-REGIONAL STUDIES
(2023)
Article
Medicine, General & Internal
Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang, Fenglong Bie, Guangyu Bai, Bolun Zhou, Zhaoyang Yang, Huiyao Huang, Yan Fang, Benjamin Li, Xiangrong Dai, Shugeng Gao, Jie He
Summary: A Phase II study evaluated the safety and efficacy of neoadjuvant socazolimab combined with nab-paclitaxel and cisplatin for locally advanced ESCC. The results showed promising major pathological response and complete pathological response rates, as well as significant T downstaging, without increasing surgical complication rates.
Letter
Oncology
Guo Zhao, Yale Jiang, Peiwen Ma, Shuhang Wang, Guangjun Nie, Ning Li
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Zheng Li, Xizhi Li, Shuhang Wang, Feifei Che, Yang Zhang, Pingjian Yang, Jinbo Zhang, Yanxiao Liu, Huaicheng Guo, Zhenghui Fu
Summary: The study analyzed the migration and distribution of heavy metals (HMs) in rivers and lakes and established a Bayesian network model to understand the impact of environmental factors on the adsorption-desorption behavior of HMs. Factors such as cation exchange capacity, organic matter, soluble fluoride, and pH were found to play important roles in HM adsorption and desorption. The study also revealed synergistic effects between environmental factors in affecting the release of bioavailable HMs. Bayesian network signals provided insights into the transfer direction of metals in the water-sediment interface.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Geochemistry & Geophysics
Zhihao Wu, Xia Jiang, Junyi Chen, Shuhang Wang
Summary: In this study, a passive sampling technique called diffusion gradients in thin films (DGT) was used to investigate the biogeochemical behaviors and dynamic transfer of PO4-P, NH4-N, and NO3-N in sediments of Lake Hulun in China. Based on the analysis of DGT concentration profiles and redox status, it was found that the release of phosphorus (P) is mainly controlled by the reductive dissolution of Mn(IV) or Fe(III) (oxyhydr)oxides, while the release of ammonium (NH4-N) is influenced by denitrification and dissimilatory nitrate reduction. The results of this study provide valuable information for lake pollution control and sediment remediation strategies.
JOURNAL OF GEOCHEMICAL EXPLORATION
(2023)
Article
Geriatrics & Gerontology
Huiyao Huang, Yu Tang, Dawei Wu, Xinyu Meng, Shuhang Wang, Jun Wang, Yue Yu, Yuan Fang, Hong Fang, Qi Zhu, Ning Li, Binghe Xu, Yan Sun, Jie He
Summary: The proportion of upper age restrictions in cancer clinical trials in mainland China is relatively high, especially for trials initiated by domestic enterprises and early-phase trials. It is crucial to take action and promote treatment equity for older patients while ensuring adequate evidence from clinical trials.
Review
Oncology
Shuhang Wang, Peiwen Ma, Ning Jiang, Yale Jiang, Yue Yu, Yuan Fang, Huilei Miao, Huiyao Huang, Qiyu Tang, Dandan Cui, Hong Fang, Huishan Zhang, Qi Fan, Yuning Wang, Gang Liu, Zicheng Yu, Qi Lei, Ning Li
Summary: Advances in novel drugs, therapies, and genetic techniques have greatly improved the prognosis of cancer patients. However, rare tumors pose challenges to precision medicine and novel therapies due to their low incidence and regional disparities, leading to difficulties in informative diagnosis, lack of recommended treatment strategies, and insufficient biomarkers for prognosis/efficacy.
FRONTIERS OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Shuhang Wang, Haoran Yang, Feifei Che, Wei Huang, Dianhai Yang
Summary: This study investigated rural domestic sewage treatment facilities in two urban areas in Jiaxing and found high concentrations of total phosphorus and ammonia nitrogen in the plain river network. A new synthetic filler (FA-SFe) was selected to enhance nitrogen and phosphorus reduction in constructed wetlands, highlighting the importance of fillers. Experiments showed the high adsorption capacity of FA-SFe, with removal rates of ammonia nitrogen and total phosphorus reaching 71.3% and 62.7% respectively in actual wastewater treatment.
FRONTIERS IN CHEMISTRY
(2023)
Article
Medicine, General & Internal
Qian Zhang, Xiuli Tao, Shijun Zhao, Ning Li, Shuhang Wang, Ning Wu
Summary: This study aims to investigate the predictive ability of clinical and chest CT features in predicting the severity of symptomatic immune checkpoint inhibitor-related pneumonitis (CIP). The results showed that the diagnostic performance of chest CT scores was better than clinical symptom scores, and the combination of the three scores demonstrated the best diagnostic value. Therefore, the clinical and chest CT features have important application value in assessing the disease severity of symptomatic CIP, and the routine use of chest CT is recommended in comprehensive clinical evaluation.
Article
Health Care Sciences & Services
Huiyao Huang, Yu Tang, Yue Yu, Anqi Yu, Dawei Wu, Hong Fang, Shuhang Wang, Chao Sun, Xin Wang, Qi Fan, Yuan Fang, Qiyu Tang, Ning Jiang, Jingting Du, Huilei Miao, Ying Bai, Peiwen Ma, Shujun Xing, Dandan Cui, Shuangman Miao, Yale Jiang, Jingxiao Zhu, Qi Zhu, Ye Leng, Lan Wei Guo, Shanmei Liao, Yaguang Shao, Yinyin Song, Zeyuan Liu, Minghuang Hong, Suxia Luo, Binghe Xu, Gongtao Lan, Ning Lia
Summary: Overall survival (OS) is a standard clinical endpoint for new drug applications, but its source and reliability in clinical trials have seldom been questioned. This study addresses the issue of data integrity and reliability when collecting OS information without sufficient supporting material, particularly in the context of the COVID-19 pandemic. Through discussions with Chinese experts, potential sources for obtaining death dates were analyzed and comprehensive strategies for improving data integrity and reliability were proposed.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Environmental Sciences
Zhihao Wu, Xia Jiang, Junyi Chen, Shuhang Wang, Cheng Yao
Summary: This research used DGT assemblies with different binding layers to study the mobility of N and P in sediments in Western Lake Taihu. The results provide important insights into the biogeochemical processes and nutrient release in lakes, which are crucial for effective nutrient management.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)