Challenges for the application of DNA methylation biomarkers in molecular diagnostic testing for cancer

Primer design versus PCR bias in methylation independent PCR amplifications

(2014) Tomasz K Wojdacz et al.   Epigenetics

DNA methylation biomarkers in cancer: progress towards clinical implementation

(2012) Thomas Mikeska et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Genome-wide DNA methylation profiles in hepatocellular carcinoma

(2012) Jing Shen et al.   HEPATOLOGY

Detection of Hypermethylated Vimentin in Urine of Patients with Colorectal Cancer

(2012) Benjamin P. Song et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Non-invasive prenatal measurement of the fetal genome

(2012) H. Christina Fan et al.   NATURE

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development

(2012) Sachi Jain et al.   PLoS One

The Limitations of Locus Specific Methylation Qualification and Quantification in Clinical Material

(2012) Tomasz K. Wojdacz   Frontiers in Genetics

Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

(2011) Jorja D Warren et al.   BMC Medicine

Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!

(2011) I. J. H. van Vlodrop et al.   CLINICAL CANCER RESEARCH

Comprehensive Genome Methylation Analysis in Bladder Cancer: Identification and Validation of Novel Methylated Genes and Application of These as Urinary Tumor Markers

(2011) T. Reinert et al.   CLINICAL CANCER RESEARCH

Assessing combined methylation–sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

(2011) Ida L.M. Candiloro et al.   Epigenetics

Methylation-sensitive high-resolution melting in the context of legislative requirements for validation of analytical procedures for diagnostic applications

(2011) Tomasz K Wojdacz   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

No difference in the frequency of locus-specific methylation in the peripheral blood DNA of women diagnosed with breast cancer and age-matched controls

(2011) Tomasz K Wojdacz et al.   Future Oncology

A Locked Nucleic Acid Clamp-Mediated PCR Assay for Detection of a p53 Codon 249 Hotspot Mutation in Urine

(2011) Selena Y. Lin et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas

(2011) Guro E Lind et al.   Molecular Cancer

Methylation of the CpG Sites Only on the Sense Strand of the APC Gene Is Specific for Hepatocellular Carcinoma

(2011) Surbhi Jain et al.   PLoS One

Cell-free DNA in the blood as a solid tumor biomarker—A critical appraisal of the literature

(2010) Klaus Jung et al.   CLINICA CHIMICA ACTA

Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma

(2010) Masahito Tsutsui et al.   CLINICA CHIMICA ACTA

Methylation Analysis by Restriction Endonuclease Digestion and Real-Time PCR

(2010) R. Mao et al.   CLINICAL CHEMISTRY

Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies

(2010) Tomasz K Wojdacz et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients

(2010) Heidi Schwarzenbach et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis

(2010) Tae-Hee Um et al.   JOURNAL OF HEPATOLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

(2010) Ju Dong Yang et al.   SEMINARS IN CANCER BIOLOGY

Detection of Mutated K-rasDNA in Urine, Plasma, and Serum of Patients with Colorectal Carcinoma or Adenomatous Polyps

(2009) Ying-Hsiu Su et al.   Annals of the New York Academy of Sciences

Removal of High-Molecular-Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of MutatedK-rasDNA in Urine

(2009) Ying-Hsiu Su et al.   Annals of the New York Academy of Sciences

Transrenal Nucleic Acids: From Proof of Principle to Clinical Tests

(2009) Hovsep S. Melkonyan et al.   Annals of the New York Academy of Sciences

hTERTmethylation and expression in gastric cancer

(2009) Carolina Oliveira Gigek et al.   BIOMARKERS

Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis

(2009) Kosuke Hosoya et al.   CANCER LETTERS

Detection of Increased Amounts of Cell-Free Fetal DNA with Short PCR Amplicons

(2009) A. Sikora et al.   CLINICAL CHEMISTRY

Optimization of Transrenal DNA Analysis: Detection of Fetal DNA in Maternal Urine

(2009) E. M. Shekhtman et al.   CLINICAL CHEMISTRY

Developmental programming of CpG island methylation profiles in the human genome

(2009) Ravid Straussman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular profiling to predict hepatocellular carcinoma outcome

(2009) Yujin Hoshida et al.   Expert Review of Gastroenterology & Hepatology

MAL promoter hypermethylation as a novel prognostic marker in gastric cancer

(2008) T E Buffart et al.   BRITISH JOURNAL OF CANCER

Methylation Array Analysis of Preoperative and Postoperative Saliva DNA in Oral Cancer Patients

(2008) C. T. Viet et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Quantitative Analysis of the Transrenal Excretion of Circulating EBV DNA in Nasopharyngeal Carcinoma Patients

(2008) K.C. A. Chan et al.   CLINICAL CANCER RESEARCH

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

(2008) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients

(2008) Frank Diehl et al.   GASTROENTEROLOGY

Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development

(2008) Fei Song et al.   GENOMICS

DNA methylation, epimutations and cancer predisposition

(2008) Alexander Dobrovic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Recurrence of Hepatocellular Carcinoma

(2008) Morris Sherman   NEW ENGLAND JOURNAL OF MEDICINE

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

(2008) Robert Illingworth et al.   PLOS BIOLOGY